The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Transcriptional Response of Yeast to Saline Stress
Open accessAbstract
Adaptation to changes in extracellular salinity is a critical event for cell survival. Genome-wide DNA chip analysis has been used to analyze the transcriptional response of yeast cells to saline stress. About 7% of the genes encoded in the yeast genome are induced more than 5-fold after a mild and brief saline shock (0.4 m NaCl, 10 min). Interestingly, most responsive genes showed a very transient expression pattern, as mRNA levels dramatically declined after 20 min in the presence of stress. A quite similar set of genes increased expression in cells subjected to higher saline concentrations (0.8 m NaCl), although in this case the response was delayed. Therefore, our data show that cells respond to saline stress by inducing the expression of a very large number of genes and suggest that stress adaptation requires regulation of many cellular aspects. The transcriptional induction of most genes that are strongly responsive to salt stress was highly or fully dependent on the presence of the stress-activated mitogen-activated protein kinase Hog1, indicating that the Hog1-mediated signaling pathway plays a key role in global gene regulation under saline stress conditions.
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Cites
Global response of Saccharomyces cerevisiae to an alkylating agent
Jelinsky, S. A., & Samson, L. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1486 · Cited by 419
Yeast putative transcription factors involved in salt tolerance
Mendizabal, I., Rios, G., Mulet, J. M., Serrano, R., & de Larrinoa, I. F. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00249-x · Cited by 136
Cited by
Osmotic Stress Signaling and Osmoadaptation in Yeasts
Hohmann, S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.300-372.2002 · Cited by 1,767
Enjalbert, B., Smith, D. A., Cornell, M. J., Alam, I., Nicholls, S., Brown, A. J. P., & Quinn, J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-06-0501 · Cited by 381
The Frequency Dependence of Osmo-Adaptation in Saccharomyces cerevisiae
Mettetal, J. T., Muzzey, D., Gómez-Uribe, C., & van Oudenaarden, A. (2008) · Science · doi:10.1126/science.1151582 · Cited by 332
Smith, D. A., Nicholls, S., Morgan, B. A., Brown, A. J. P., & Quinn, J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-03-0181 · Cited by 263
O'Rourke, S. M., & Herskowitz, I. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-07-0521 · Cited by 263
Metadata
- Authors
- Posas, F., Chambers, J. R., Heyman, J. A., Hoeffler, J. P., de Nadal, E., & Ariño, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 275
- Issue
- 23
- Pages
- 17249-17255
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2035303243
- Cited by
- 423
- References
- 2
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Posas, F., Chambers, J. R., Heyman, J. A., Hoeffler, J. P., de Nadal, E., & Ariño, J. (2000). The Transcriptional Response of Yeast to Saline Stress. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m910016199
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