The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The Frequency Dependence of Osmo-Adaptation in Saccharomyces cerevisiae
Open accessAbstract
The propagation of information through signaling cascades spans a wide range of time scales, including the rapid ligand-receptor interaction and the much slower response of downstream gene expression. To determine which dynamic range dominates a response, we used periodic stimuli to measure the frequency dependence of signal transduction in the osmo-adaptation pathway of Saccharomyces cerevisiae . We applied system identification methods to infer a concise predictive model. We found that the dynamics of the osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 that does not require protein synthesis. After large osmotic shocks, an additional, much slower, negative feedback through gene expression allows cells to respond faster to future stimuli.
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Cites
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Ma, W., Trusina, A., El-Samad, H., Lim, W. A., & Tang, C. (2009) · Cell · doi:10.1016/j.cell.2009.06.013 · Cited by 919
p53 Dynamics Control Cell Fate
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Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module
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Measurement of single-cell dynamics
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Metadata
- Authors
- Mettetal, J. T., Muzzey, D., Gómez-Uribe, C., & van Oudenaarden, A.
- Venue
- Science
- Published
- 2008-01-25
- Volume
- 319
- Issue
- 5862
- Pages
- 482-484
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1987315263
- Cited by
- 332
- References
- 23
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Mettetal, J. T., Muzzey, D., Gómez-Uribe, C., & van Oudenaarden, A. (2008). The Frequency Dependence of Osmo-Adaptation in Saccharomyces cerevisiae. Science. https://doi.org/10.1126/science.1151582
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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