The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target
Open accessAbstract
Hepatitis C virus non-structural protein 3 contains a serine protease and an RNA helicase. Protease cleaves the genome-encoded polyprotein and inactivates cellular proteins required for innate immunity. Protease has emerged as an important target for the development of antiviral therapeutics, but drug resistance has turned out to be an obstacle in the clinic. Helicase is required for both genome replication and virus assembly. Mechanistic and structural studies of helicase have hurled this enzyme into a prominent position in the field of helicase enzymology. Nevertheless, studies of helicase as an antiviral target remain in their infancy.
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Cites
Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature · doi:10.1038/nature04193 · Cited by 2,401
Cited by
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
Gerold, G., & Pietschmann, T. (2014) · Digestive Diseases · doi:10.1159/000360830 · Cited by 4,854
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
Scheel, T. K. H., & Rice, C. M. (2013) · Nature Medicine · doi:10.1038/nm.3248 · Cited by 554
Revisiting the central dogma one molecule at a time
Bustamante, C., Cheng, W., & Mejia, Y. X. (2011) · Cell · doi:10.1016/j.cell.2011.01.033 · Cited by 173
Metadata
- Authors
- Raney, K. D., Sharma, S. D., Moustafa, I. M., & Cameron, C. E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 285
- Issue
- 30
- Pages
- 22725-22731
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2025807248
- Cited by
- 177
- References
- 3
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Raney, K. D., Sharma, S. D., Moustafa, I. M., & Cameron, C. E. (2010). Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.r110.125294
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
