The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Mammalian Siderophores, Siderophore-binding Lipocalins, and the Labile Iron Pool
Open accessAbstract
Bacteria use tight-binding, ferric-specific chelators called siderophores to acquire iron from the environment and from the host during infection; animals use proteins such as transferrin and ferritin to transport and store iron. Recently, candidate compounds that could serve endogenously as mammalian siderophore equivalents have been identified and characterized through associations with siderocalin, the only mammalian siderophore-binding protein currently known. Siderocalin, an antibacterial protein, acts by sequestering iron away from infecting bacteria as siderophore complexes. Candidate endogenous siderophores include compounds that only effectively transport iron as ternary complexes with siderocalin, explaining pleiotropic activities in normal cellular processes and specific disease states.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These are best characterized in bacteria, but eukaryotes including fungi and mammals produce siderophores, too [16, 42, 67, 86, 106].”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Two to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
Flo, T. H., Smith, K. D., Sato, S., Rodriguez, D. J., Holmes, M. A., Strong, R. K., Akira, S., & Aderem, A. (2004) · Nature · doi:10.1038/nature03104 · Cited by 1,877
Self-citationMicroorganisms pumping iron: anaerobic microbial iron oxidation and reduction
Weber, K. A., Achenbach, L. A., & Coates, J. D. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1490 · Cited by 1,831
Siderophore-Based Iron Acquisition and Pathogen Control
Miethke, M., & Marahiel, M. A. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00012-07 · Cited by 1,774
Siderophores: Structure and Function of Microbial Iron Transport Compounds
Neilands, J. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26723 · Cited by 1,652
Goetz, D. H., Holmes, M. A., Borregaard, N., Bluhm, M. E., Raymond, K. N., & Strong, R. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00708-6 · Cited by 1,355
Self-citationNeilands, J. B. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.003435 · Cited by 1,232
Bacterial Iron Sources: From Siderophores to Hemophores
Wandersman, C., & Delepelaire, P. (2004) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123811 · Cited by 1,095
Enterobactin: an archetype for microbial iron transport.
Raymond, K. N., Dertz, E. A., & Kim, S. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630018100 · Cited by 933
Iron withholding: a defense against infection and neoplasia
Weinberg, E. D. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.1.65 · Cited by 881
Cited by
Sorted by citations
Items 101–115 of 115
Ecker, F., Haas, H., Groll, M., & Huber, E. M. (2018) · Angewandte Chemie · doi:10.1002/ange.201807093 · Cited by 1
The DOPA scaffold: Tracing catechol chemistry from prebiotic earth to cognitive agency
Alachkar, A. (2025) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2025.10.004 · Cited by 1
Siderocalin Combats Mycobacterial Infections
Allred, B. E., Sia, A. K., & Raymond, K. N. (2013) · Springer briefs in molecular science · doi:10.1007/978-3-319-00303-0_4 · Cited by 1
Metals in Bacterial Pathogenicity and Immunity
Cavet, J. S. (2004) · Wiley eBooks · doi:10.1002/9781119951438.eibc2141 · Cited by 1
Iron and Heme Transport and Trafficking
Yien, Y. Y., & Paw, B. H. (2004) · Wiley eBooks · doi:10.1002/9781119951438.eibc2117 · Cited by 1
Ahmad, S. (2014) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4633
Lazarillo and Related Lipocalins: Ligands and Funcions
García, M. R. (2013) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/3603 · Cited by 1
Iron: Mitochondrial Iron Metabolism and the Synthesis of Iron–Sulfur Clusters
Dancis, A., & Lindahl, P. A. (2004) · Wiley eBooks · doi:10.1002/9781119951438.eibc2147
Design, Synthesis, and Application of Photoactive Complexes of Biologically Relevant Metals
Gwizdala, C. (2013) · OpenCommons at University of Connecticut (University of Connecticut)
Micronutrient Deficiency and Immunity
Cusick, S. E., & John, C. C. (2014) · CRC Press eBooks · doi:10.1201/b17311-4
Crichton, R. R. (2016) · Wiley eBooks · doi:10.1002/9781118925645.ch4
Estudio de la alergenicidad en Alt a 1, una proteína única de hongos
Garrido‐Arandia, M. (2016) · doi:10.20868/upm.thesis.42943
The influence of an iron deficient diet on the murine gut microbiome
Coe, G. L. (2019) · Montana State University ScholarWorks (Montana State University)
Ha, C. E., & Bhagavan, N. V. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-88541-6.00011-9
Metadata
- Authors
- Correnti, C., & Strong, R. K.
- Affiliations
- Fred Hutch Cancer Center (US)
- Corresponding author
- Strong, Roland K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 287
- Issue
- 17
- Pages
- 13524-13531
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3340207
- OpenAlex
- W1990262536
- Cited by
- 115
- References
- 88
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 11 · 2020: 4 · 2019: 12 · 2018: 8 · 2017: 6 · 2016: 10 · 2015: 11 · 2014: 12 · 2013: 12 · 2012: 6
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI 059432, R01AI059432)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK073462, R21DK091729, DK091729, DK073462)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- siderocalin, labile iron pool, iron acquisition, iron transport, iron storage, transferrin, ferritin, antibacterial proteins
- MeSH terms
- Lipocalin-2, Animals, Anti-Bacterial Agents, Biological Transport, Carrier Proteins, Catechols, Chelating Agents, Humans, Hydrogen-Ion Concentration, Immunity, Innate, Iron, Kinetics, Models, Biological, Models, Chemical, Apoptosis, Siderophores, Lipocalins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
