The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Battles with Iron: Manganese in Oxidative Stress Protection
Open accessAbstract
The redox-active metal manganese plays a key role in cellular adaptation to oxidative stress. As a cofactor for manganese superoxide dismutase or through formation of non-proteinaceous manganese antioxidants, this metal can combat oxidative damage without deleterious side effects of Fenton chemistry. In either case, the antioxidant properties of manganese are vulnerable to iron. Cellular pools of iron can outcompete manganese for binding to manganese superoxide dismutase, and through Fenton chemistry, iron may counteract the benefits of non-proteinaceous manganese antioxidants. In this minireview, we highlight ways in which cells maximize the efficacy of manganese as an antioxidant in the midst of pro-oxidant iron.
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Citations
Cites
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The Effects of Mitochondrial Iron Homeostasis on Cofactor Specificity of Superoxide Dismutase 2
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The Interaction of Mitochondrial Iron with Manganese Superoxide Dismutase
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Self-citation
Cited by
Superoxide dismutases and superoxide reductases
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Mitochondria and Iron: current questions
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Metadata
- Authors
- Aguirre, J. D., & Culotta, V. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 287
- Issue
- 17
- Pages
- 13541-13548
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2036668697
- Cited by
- 303
- References
- 8
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
