Cited by 91Estrogen and related hormone effectsCytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Glucocorticoid and cytokine crosstalk: Feedback, feedforward, and co-regulatory interactions determine repression or resistance

Open access
Newton, Robert, Shah, Suharsh, Altonsy, Mohammed O., Gerber, Antony N.·2017·Journal of Biological Chemistry

Abstract

Inflammatory signals induce feedback and feedforward systems that provide temporal control. Although glucocorticoids can repress inflammatory gene expression, glucocorticoid receptor recruitment increases expression of negative feedback and feedforward regulators, including the phosphatase, DUSP1, the ubiquitin-modifying enzyme, TNFAIP3, or the mRNA-destabilizing protein, ZFP36. Moreover, glucocorticoid receptor cooperativity with factors, including nuclear factor-κB (NF-κB), may enhance regulator expression to promote repression. Conversely, MAPKs, which are inhibited by glucocorticoids, provide feedforward control to limit expression of the transcription factor IRF1, and the chemokine, CXCL10. We propose that modulation of feedback and feedforward control can determine repression or resistance of inflammatory gene expression toglucocorticoid.

Integrity signals

Registry

Crossref · 10.1074/jbc.r117.777318

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Newton, R., Shah, S., Altonsy, M. O., & Gerber, A. N.
Affiliations
  • University of Calgary (CA)
  • National Jewish Health (US)
Corresponding author
Newton, Robert
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2017-04
Volume
292
Issue
17
Pages
7163-7172
ISSN
0021-9258 (ISSN-L)
OpenAlex
W2593975322
Cited by
91
References
99
Citations by year
2026: 5 · 2025: 6 · 2024: 10 · 2023: 14 · 2022: 9 · 2021: 16 · 2020: 16 · 2019: 7 · 2018: 5 · 2017: 3
FWCI
1.09
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canadian Institutes of Health Research (MOP 125918)
  • Alberta Innovates - Health Solutions (Senior Scholar)
  • National Heart, Lung, and Blood Institute (R01 HL-109557)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords
glucocorticoid receptor, glucocorticoid resistance, inflammatory gene expression, negative feedback regulation, feedforward control, cytokine signaling, MKP-1, A20, ZFP36, NF-κB, MAPK signaling, IRF1, CXCL10, transcriptional repression
MeSH terms
A549 Cells, Tumor Necrosis Factor alpha-Induced Protein 3, Animals, Gene Expression Regulation, Glucocorticoids, Humans, Inflammation, Receptors, Glucocorticoid, RNA, Messenger, Signal Transduction, Gene Expression Regulation, Neoplastic, Cytokines, NF-kappa B, MAP Kinase Signaling System, Feedback, Physiological, Interferon Regulatory Factor-1, Mice, Tristetraprolin, Transcription Factor RelA, Chemokine CXCL10, Dual Specificity Phosphatase 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review