Cited by 265Estrogen and related hormone effectsNF-κB Signaling PathwaysAdrenal Hormones and Disorders

Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors

De Bosscher, K·2000·Journal of Neuroimmunology

Abstract

Glucocorticoids are the most widely used anti-inflammatory and immunomodulatory agents, whose mechanism of action is based mainly on interference with the activity of transcription factors, such as nuclear factor kappaB (NF-kappaB) and activator protein-1 (AP-1). The precise molecular mechanisms of gene repression by glucocorticoids are a controversial matter, due to the existence of many conflicting hypotheses. We discuss the three main paradigms reported in the literature, namely the inhibitor kappaB-alpha (IkappaB-alpha) upregulatory model, the protein-protein interaction model and the competition model.

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Crossref · 10.1016/s0165-5728(00)00297-6

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52 of 52 references verified0 citation errors · 0 not checkable

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  • One of the mechanisms underlying the anti-inflammatory effects of GCs is the inhibition of nuclear factor-κB (NF-κB), a major transcription factor for the inflammatory-response genes.

    “For example, one of the mechanisms underlying the anti-inflammatory effects of GCs is the inhibition of nuclear factor-κB (NF-κB), a major transcription factor for the inflammatory-response genes (De Bosscher et al, 2000).”

    From Microglia Priming with Aging and Stress (2017) · cites this paper as De Bosscher et al, 2000

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Authors
De Bosscher, K.
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2000-09-01
Volume
109
Issue
1
Pages
16-22
ISSN
0165-5728 (ISSN-L)
OpenAlex
W2148930555
Cited by
264
References
52
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 10 · 2020: 8 · 2019: 5 · 2018: 12 · 2017: 12 · 2016: 10 · 2015: 10 · 2014: 10 · 2013: 7 · 2012: 9
FWCI
10.49
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
glucocorticoids, anti-inflammatory activity, immunosuppression, glucocorticoid receptor, transcription factors, NF-κB, AP-1, gene repression, IκBα, protein-protein interaction, competition model
MeSH terms
NF-KappaB Inhibitor alpha, Animals, Anti-Inflammatory Agents, DNA-Binding Proteins, Glucocorticoids, Humans, Immunosuppressive Agents, Receptors, Glucocorticoid, Transcription Factors, NF-kappa B, Cyclic AMP Response Element-Binding Protein, I-kappa B Proteins

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