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Iron–sulfur cluster biogenesis and trafficking in mitochondria
Open accessAbstract
The biogenesis of iron-sulfur (Fe/S) proteins in eukaryotes is a multistage, multicompartment process that is essential for a broad range of cellular functions, including genome maintenance, protein translation, energy conversion, and the antiviral response. Genetic and cell biological studies over almost 2 decades have revealed some 30 proteins involved in the synthesis of cellular [2Fe-2S] and [4Fe-4S] clusters and their incorporation into numerous apoproteins. Mechanistic aspects of Fe/S protein biogenesis continue to be elucidated by biochemical and ultrastructural investigations. Here, we review recent developments in the pursuit of constructing a comprehensive model of Fe/S protein assembly in the mitochondrion.
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“Once inside the organelle the iron is incorporated into heme and iron-sulfur (Fe-S) clusters by frataxin and GLRX5 (Glutaredoxin-related protein 5) (Lill, 2009; Braymer and Lill, 2017).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Braymer and Lill, 2017
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Metadata
- Authors
- Braymer, J. J., & Lill, R.
- Affiliations
- Philipps University of Marburg (DE)
- Corresponding author
- Lill, Roland
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 292
- Issue
- 31
- Pages
- 12754-12763
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC5546016
- OpenAlex
- W2625087901
- Cited by
- 389
- References
- 100
- Citations by year
- 2026: 29 · 2025: 29 · 2024: 32 · 2023: 39 · 2022: 45 · 2021: 40 · 2020: 56 · 2019: 44 · 2018: 57 · 2017: 16
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (Koselleck grant, LI 415/5, SFB 987, SPP 1710, and SPP 1927)
- German-Israeli Foundation for Scientific Research and Development (I-1302-412.13/2015)
- H2020 Marie Skłodowska-Curie Actions (659325)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Metalloenzymes and iron-sulfur proteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Keywords
- iron-sulfur clusters, mitochondrial iron-sulfur proteins, [2Fe-2S] cluster, [4Fe-4S] cluster, cluster assembly, iron-sulfur proteins, genome maintenance, mRNA translation, energy conversion, antiviral response
- MeSH terms
- Frataxin, Acyl Carrier Protein, Adrenodoxin, Animals, Apoenzymes, Humans, Iron-Sulfur Proteins, Mitochondria, Models, Biological, Models, Molecular, Protein Conformation, Species Specificity, Sulfurtransferases, Gene Expression Regulation, Enzymologic, Protein Folding, Protein Transport, Mitochondrial Proteins, Saccharomyces cerevisiae Proteins, Iron-Binding Proteins, Protein Multimerization
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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