Cited by 73Lipid Membrane Structure and BehaviorSphingolipid Metabolism and SignalingLipid metabolism and biosynthesis

Lipid-binding Proteins in Membrane Digestion, Antigen Presentation, and Antimicrobial Defense

Open access
Kolter, Thomas, Winau, Florian, Schaible, Ulrich E., Leippe, Matthias, Sandhoff, Konrad·2005·Journal of Biological Chemistry

Abstract

Membrane-active proteins are able to bind lipid molecules, transfer lipids to proteins or to target membranes, and selectively perturb lipid bilayers (1). They differ in binding specificity and subcellular localization and also in their cytoplasmic, extracytoplasmic, and intercellular topology and functions. Lipid-binding proteins include, for example, cholesterol-binding proteins, like NPC-1 and -2 or ABCA1 (1). A subset of lipid-binding proteins has a major role in the lysosomal degradation of sphingolipids with short hydrophilic head groups.

Integrity signals

Registry

Crossref · 10.1074/jbc.r500015200

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Lysosomal lipid transfer proteins such as the four active saposins generated from pro-saposin by proteolytic cleavage are essential for glyco-lipid degradation and glyco-lipid homeostasis, in addition to their function in processing and presentation of lipid antigens by CD1b molecules in DC.

    “Lysosomal lipid transfer proteins (LTPs), such as the four active saposins generated from pro-saposin by proteolytic cleavage, are essential for glyco-lipid degradation in lysosomes and glyco-lipid homeostasis, in addition to their immunologically relevant function in processing and presentation of lipid antigens by CD1b molecules in DC (41, 42).”

    From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [41]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kolter, T., Winau, F., Schaible, U. E., Leippe, M., & Sandhoff, K.
Affiliations
Max Planck Society (DE)
Corresponding author
Sandhoff, Konrad
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2005-12
Volume
280
Issue
50
Pages
41125-41128
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1999525103
Cited by
73
References
74
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 8 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
0.40
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
lipid-binding proteins, lipid bilayer perturbation, cholesterol-binding protein, NPC1, NPC2, ABCA1, membrane digestion, antigen presentation, antimicrobial defense
MeSH terms
Animals, Anti-Infective Agents, Antigens, Differentiation, T-Lymphocyte, Bacterial Proteins, beta-N-Acetylhexosaminidases, Cell Membrane, G(M2) Ganglioside, Humans, Ion Channels, Lipids, Models, Biological, Models, Molecular, Protein Binding, Protozoan Proteins, Protein Structure, Tertiary, Antigen Presentation, Fatty Acid-Binding Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review