Lipid-binding Proteins in Membrane Digestion, Antigen Presentation, and Antimicrobial Defense
Open accessAbstract
Membrane-active proteins are able to bind lipid molecules, transfer lipids to proteins or to target membranes, and selectively perturb lipid bilayers (1). They differ in binding specificity and subcellular localization and also in their cytoplasmic, extracytoplasmic, and intercellular topology and functions. Lipid-binding proteins include, for example, cholesterol-binding proteins, like NPC-1 and -2 or ABCA1 (1). A subset of lipid-binding proteins has a major role in the lysosomal degradation of sphingolipids with short hydrophilic head groups.
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Lysosomal lipid transfer proteins such as the four active saposins generated from pro-saposin by proteolytic cleavage are essential for glyco-lipid degradation and glyco-lipid homeostasis, in addition to their function in processing and presentation of lipid antigens by CD1b molecules in DC.
“Lysosomal lipid transfer proteins (LTPs), such as the four active saposins generated from pro-saposin by proteolytic cleavage, are essential for glyco-lipid degradation in lysosomes and glyco-lipid homeostasis, in addition to their immunologically relevant function in processing and presentation of lipid antigens by CD1b molecules in DC (41, 42).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [41]
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Ganglioside Metabolism and Its Inherited Diseases
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- Authors
- Kolter, T., Winau, F., Schaible, U. E., Leippe, M., & Sandhoff, K.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Sandhoff, Konrad
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 280
- Issue
- 50
- Pages
- 41125-41128
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1999525103
- Cited by
- 73
- References
- 74
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 8 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- lipid-binding proteins, lipid bilayer perturbation, cholesterol-binding protein, NPC1, NPC2, ABCA1, membrane digestion, antigen presentation, antimicrobial defense
- MeSH terms
- Animals, Anti-Infective Agents, Antigens, Differentiation, T-Lymphocyte, Bacterial Proteins, beta-N-Acetylhexosaminidases, Cell Membrane, G(M2) Ganglioside, Humans, Ion Channels, Lipids, Models, Biological, Models, Molecular, Protein Binding, Protozoan Proteins, Protein Structure, Tertiary, Antigen Presentation, Fatty Acid-Binding Proteins
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