The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Lipoic acid metabolism and mitochondrial redox regulation
Open accessAbstract
-adenosylmethionine and iron-sulfur clusters. This cofactor is required for catalysis by multiple mitochondrial 2-ketoacid dehydrogenase complexes, including pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, and branched-chain ketoacid dehydrogenase. Lipoic acid also plays a critical role in stabilizing and regulating these multienzyme complexes. Many of these dehydrogenases are regulated by reactive oxygen species, mediated through the disulfide bond of the prosthetic lipoyl moiety. Collectively, its functions explain why lipoic acid is required for cell growth, mitochondrial activity, and coordination of fuel metabolism.
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Cites
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Cited by
Copper induces cell death by targeting lipoylated TCA cycle proteins
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Cuproptosis: mechanisms and links with cancers
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Chiral Posttranslational Modification to Lysine ε-Amino Groups
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Metadata
- Authors
- Solmonson, A., & DeBerardinis, R. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 293
- Issue
- 20
- Pages
- 7522-7530
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2772709248
- Cited by
- 489
- References
- 62
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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