The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.
Cuproptosis: mechanisms and links with cancers
Open accessAbstract
Cuproptosis was a copper-dependent and unique kind of cell death that was separate from existing other forms of cell death. The last decade has witnessed a considerable increase in investigations of programmed cell death, and whether copper induced cell death was an independent form of cell death has long been argued until mechanism of cuproptosis has been revealed. After that, increasing number of researchers attempted to identify the relationship between cuproptosis and the process of cancer. Thus, in this review, we systematically detailed the systemic and cellular metabolic processes of copper and the copper-related tumor signaling pathways. Moreover, we not only focus on the discovery process of cuproptosis and its mechanism, but also outline the association between cuproptosis and cancers. Finally, we further highlight the possible therapeutic direction of employing copper ion ionophores with cuproptosis-inducing functions in combination with small molecule drugs for targeted therapy to treat specific cancers.
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1 retracted
Wang, L., Chai, X., Wan, R., Zhang, H., Zhou, C., Lin, X., Paul, M. E., & Li, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.595718 · Cited by 38
RetractedOxygen toxicity, oxygen radicals, transition metals and disease
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Copper induces cell death by targeting lipoylated TCA cycle proteins
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Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
Nusse, R., & Clevers, H. (2017) · Cell · doi:10.1016/j.cell.2017.05.016 · Cited by 4,342
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?
Sabharwal, S. S., & Schumacker, P. T. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3803 · Cited by 1,622
Mechanisms for copper acquisition, distribution and regulation
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Mitochondrial metabolism and cancer
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Copper: An essential metal in biology
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Targeting Metabolism for Cancer Therapy
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Cited by
Navigating the complexities of cell death: Insights into accidental and programmed cell death
Lotfi, M.-S., & Rassouli, F. B. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102586 · Cited by 15
Metadata
- Authors
- Xie, J., Yang, Y., Gao, Y., & He, J.
- Venue
- Molecular Cancer
- Published
- 2023-03-07
- Volume
- 22
- Issue
- 1
- Pages
- 46-46
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W4323362353
- Cited by
- 801
- References
- 215
- FWCI
- 134.39
- Type
- journal article
- Language
- en
- Open access
- gold
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- Xie, J., Yang, Y., Gao, Y., & He, J. (2023). Cuproptosis: mechanisms and links with cancers. Molecular Cancer. https://doi.org/10.1186/s12943-023-01732-y
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
