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Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer
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Phosphorylation at corresponding sites in SNX1, SNX3, SNX12, and SNX17 has been reported in various cancer types.
“phosphorylation at corresponding sites in SNX1, SNX3, SNX12, and SNX17 has been reported in various cancer types (47, 48, 49, 50, 51, 52)”
From Phosphorylation of SNX17 impedes activation of Retriever-mediated sorting (2025) · cites this paper as [50]
The Dasatinib Sensitivity tables and Discussion report phosphorylation sites in other proteins, but do not address SNX1, SNX3, SNX12, or SNX17 at corresponding sites. Searches for those SNX names and for sorting-ne xin phosphorylation found no passage supporting the claim across cancer types. (LLM, conf=0.72)
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“According to the IARC TP53 database (55), six of seven sensitive and three of five nonsensitive cell lines have a mutation in the p53 protein (seven cell lines were FIG.”
MethodHuang, F., Reeves, K., Han, X., Fairchild, C., Platero, S., Wong, T. W., Lee, F., Shaw, P., & Clark, E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3633 · Cited by 344 · cited 3×
“were also determined in-house and compared with the previously reported values (5).”
BackgroundResultAnalysis of High Accuracy, Quantitative Proteomics Data in the MaxQB Database
Schaab, C., Geiger, T., Stoehr, G., Cox, J., & Mann, M. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.014068 · Cited by 164
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Cited by
Sorted by citations
Phosphorylation of SNX17 impedes activation of Retriever-mediated sorting
Speidel, J. D., Yu, K., & Böttcher, R. T. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110222
Metadata
- Authors
- Klammer, M., Kaminski, M., Zedler, A., Oppermann, F., Blencke, S., Marx, S., Müller, S., Tebbe, A., Godl, K., & Schaab, C.
- Venue
- Molecular & Cellular Proteomics
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 11
- Issue
- 9
- Pages
- 651-668
- ISSN
- 1535-9476
- Cited by
- 118
- References
- 4
- Language
- en
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