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Apolipoprotein A1 Forms 5/5 and 5/4 Antiparallel Dimers in Human High-density Lipoprotein
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“The binding of Fab and F’(ab)2 fragments to ApoE on discoidal particles suggest that the ApoE proteins are in an antiparallel conformation similar to the conformation described for apolipoprotein A1 (ApoA1) [17, 59, 60].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [60]
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“This is similar to ApoA1 in HDL which adopts an antiparallel dimer [60, 119].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [60]
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Cites
High-Density Lipoprotein — The Clinical Implications of Recent Studies
Desforges, J. F., Gordon, D. J., & Rifkind, B. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198911093211907 · Cited by 1,547
Vaisar, T., Pennathur, S., Green, P. S., Gharib, S. A., Hoofnagle, A. N., Cheung, M. C., Byun, J., Vuletic, S., Kassim, S., Singh, P., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26206 · Cited by 942
Self-citationXiao, C., Dash, S., Morgantini, C., Hegele, R. A., & Lewis, G. F. (2016) · Diabetes · doi:10.2337/db16-0046 · Cited by 212
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Cited by
Sorted by citations
Strickland, M. R., & Holtzman, D. M. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00970-0
Metadata
- Authors
- He, Y., Song, H. D., Anantharamaiah, G. M., Palgunachari, M. N., Bornfeldt, K. E., Segrest, J. P., & Heinecke, J. W.
- Venue
- Molecular & Cellular Proteomics
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 18
- Issue
- 5
- Pages
- 854a-864
- ISSN
- 1535-9476
- Cited by
- 29
- References
- 3
- Language
- en
- Licence
- Funders
- HHS | National Institutes of Health (P01HL092969, DP3DK108209, P01HL128203)
- American Heart Association (15POST22700033)
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