Cited by 88Stress Responses and CortisolAdrenal Hormones and DisordersHypothalamic control of reproductive hormones

Hypothalamic–pituitary–adrenal function

Open access
Lightman, S.L., Windle, R.J., Ma, X.-M., Harbuz, M.S., Shanks, N.M., Julian, M.D., Wood, S.A., Kershaw, Y.M. +1 more·2002·Archives of Physiology and Biochemistry

Abstract

Basal hypothalamic-pituitary-adrenal (HPA) function is characterised by pulses of corticosterone secretion followed by a transient refractory period when the axis appears to be inhibited. In females pulses of corticosterone secretion occur approximately once per hour with variation in pulse amplitude underlying a diurnal rhythm. Males show smaller pulses of secretion which become widely spaced during the early light phase nadir. Pulsatility is altered by genetic programming, early life experiences and reproductive status. Activation of the HPA axis during adjuvant induced arthritis results in an increase in the pulse frequency. This is associated with a marked change in hypothalamic gene expression with a diminution of CRH mRNA and a marked increase of AVP mRNA which becomes the predominant HPA secretagogue.

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Crossref · 10.1076/apab.110.1.90.899

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17 of 17 references verified0 citation errors · 0 not checkable

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Authors
Lightman, S. L., Windle, R. J., Ma, X.-M., Harbuz, M. S., Shanks, N. M., Julian, M. D., Wood, S. A., Kershaw, Y. M., & Ingram, C. D.
Affiliations
University of Bristol (GB)
Corresponding author
Lightman, S.L.
Venue
Archives of Physiology and Biochemistry
Published
2002-01
Volume
110
Issue
1-2
Pages
90-93
ISSN
  • 0778-3124 (ISSN-L)
  • 1381-3455
  • 1744-4160
OpenAlex
W2166776495
Cited by
88
References
17
Citations by year
2026: 1 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 3 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 9 · 2012: 7
FWCI
1.10
Type
journal article
Language
en
Open access
Locations
  • Archives of Physiology and Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
  • Explore Bristol Research (publishedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
hypothalamic-pituitary-adrenal axis, corticosterone secretion, pulsatile hormone secretion, diurnal cycle, sex differences, genetic programming, early life experience, reproductive status, adjuvant-induced arthritis, hypothalamic gene expression, CRH mRNA
MeSH terms
Adrenal Glands, Aging, Animals, Animals, Newborn, Corticosterone, Hypothalamus, Pituitary Gland, Anterior, Stress, Physiological

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