Hypothalamic–pituitary–adrenal function
Open accessAbstract
Basal hypothalamic-pituitary-adrenal (HPA) function is characterised by pulses of corticosterone secretion followed by a transient refractory period when the axis appears to be inhibited. In females pulses of corticosterone secretion occur approximately once per hour with variation in pulse amplitude underlying a diurnal rhythm. Males show smaller pulses of secretion which become widely spaced during the early light phase nadir. Pulsatility is altered by genetic programming, early life experiences and reproductive status. Activation of the HPA axis during adjuvant induced arthritis results in an increase in the pulse frequency. This is associated with a marked change in hypothalamic gene expression with a diminution of CRH mRNA and a marked increase of AVP mRNA which becomes the predominant HPA secretagogue.
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Stojiljković, A., Čupić, Ž., Maćešić, S. R., Ivanović-Šašić, A., & Mojović, M. (2025) · Royal Society Open Science · doi:10.1098/rsos.251323
- Authors
- Lightman, S. L., Windle, R. J., Ma, X.-M., Harbuz, M. S., Shanks, N. M., Julian, M. D., Wood, S. A., Kershaw, Y. M., & Ingram, C. D.
- Affiliations
- University of Bristol (GB)
- Corresponding author
- Lightman, S.L.
- Venue
- Archives of Physiology and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2002-01
- Volume
- 110
- Issue
- 1-2
- Pages
- 90-93
- ISSN
- 0778-3124 (ISSN-L)
- 1381-3455
- 1744-4160
- OpenAlex
- W2166776495
- Cited by
- 88
- References
- 17
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 3 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 9 · 2012: 7
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Archives of Physiology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- hypothalamic-pituitary-adrenal axis, corticosterone secretion, pulsatile hormone secretion, diurnal cycle, sex differences, genetic programming, early life experience, reproductive status, adjuvant-induced arthritis, hypothalamic gene expression, CRH mRNA
- MeSH terms
- Adrenal Glands, Aging, Animals, Animals, Newborn, Corticosterone, Hypothalamus, Pituitary Gland, Anterior, Stress, Physiological
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