Cited by 29Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Magnocellular hypothalamic system and its interaction with the hypothalamo-pituitary-adrenal axis

Sivukhina, Elena V., Jirikowski, Gustav F.·2016·Steroids

Abstract

The hypothalamo-neurohypophyseal system plays a key role in maintaining homeostasis and in regulation of numerous adaptive reactions, e.g., endocrine stress response. Nonapeptides vasopressin and oxytocin are the major hormones of this system. They are synthesized by magnocellular neurons of the paraventricular and supraoptic hypothalamic nuclei. Magnocellular vasopressin is known to be one of the main physiological regulators of water-electrolyte balance. Its importance for control of the hypothalamo-pituitary-adrenal axis has been widely described. Magnocellular oxytocin is secreted predominantly during lactation and parturition. The complex actions of oxytocin within the brain include control of reproductive behavior and its involvement in central stress response to different stimuli. It's neuroendocrine basis is activation of the hypothalamo-pituitary-adrenal axis: corticotropin-releasing hormone is synthesized in parvocellular neurons of the paraventricular hypothalamic nuclei. The transitory coexpression of vasopressin in these cells upon stress has been described. Glucocorticoids, the end products of the hypothalamo-pituitary-adrenal axis have both central and peripheral actions. Their availability to target tissues is mainly dependent on systemic levels of corticosteroid-binding globulin. Intrinsic expression of this protein in different brain regions in neurons and glial cells has been recently demonstrated. Regulation of the hypothalamo-pituitary-adrenal axis and hy…

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Crossref · 10.1016/j.steroids.2016.01.008

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  • Magnocellular AVP neurons in the PVN and SON release AVP both centrally and systemically in response to dehydration, hemorrhage, and stress and are primary physiological regulators of water-electrolyte balance.

    “Magnocellular AVP neurons in the PVN and SON release AVP both centrally and systemically in response to dehydration, hemorrhage, and stress and are known to be one of the primary physiological regulators of water-electrolyte balance (145).”

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Authors
Sivukhina, E. V., & Jirikowski, G. F.
Affiliations
Jena University Hospital (DE)
Corresponding author
Jirikowski, Gustav F.
Venue
Steroids
Publisher
Elsevier BV
Published
2016-07
Volume
111
Pages
21-28
ISSN
0039-128X (ISSN-L)
OpenAlex
W2253922932
Cited by
29
References
114
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 1
FWCI
0.73
Type
journal article
Language
en
Open access
closed
Locations
  • Steroids (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
magnocellular neurons, hypothalamo-neurohypophysial system, hypothalamic-pituitary-adrenal axis, vasopressin, oxytocin, paraventricular nucleus, supraoptic nucleus, corticotropin-releasing factor, glucocorticoids, corticosteroid-binding globulin, fluid and electrolyte balance, stress response, lactation, childbirth, reproductive behavior, neuroendocrine regulation, chronic disease pathogenesis
MeSH terms
Animals, Glucocorticoids, Humans, Hypothalamus, Oxytocin, Pituitary-Adrenal System, Vasopressins

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