Magnocellular hypothalamic system and its interaction with the hypothalamo-pituitary-adrenal axis
Abstract
The hypothalamo-neurohypophyseal system plays a key role in maintaining homeostasis and in regulation of numerous adaptive reactions, e.g., endocrine stress response. Nonapeptides vasopressin and oxytocin are the major hormones of this system. They are synthesized by magnocellular neurons of the paraventricular and supraoptic hypothalamic nuclei. Magnocellular vasopressin is known to be one of the main physiological regulators of water-electrolyte balance. Its importance for control of the hypothalamo-pituitary-adrenal axis has been widely described. Magnocellular oxytocin is secreted predominantly during lactation and parturition. The complex actions of oxytocin within the brain include control of reproductive behavior and its involvement in central stress response to different stimuli. It's neuroendocrine basis is activation of the hypothalamo-pituitary-adrenal axis: corticotropin-releasing hormone is synthesized in parvocellular neurons of the paraventricular hypothalamic nuclei. The transitory coexpression of vasopressin in these cells upon stress has been described. Glucocorticoids, the end products of the hypothalamo-pituitary-adrenal axis have both central and peripheral actions. Their availability to target tissues is mainly dependent on systemic levels of corticosteroid-binding globulin. Intrinsic expression of this protein in different brain regions in neurons and glial cells has been recently demonstrated. Regulation of the hypothalamo-pituitary-adrenal axis and hy…
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Magnocellular AVP neurons in the PVN and SON release AVP both centrally and systemically in response to dehydration, hemorrhage, and stress and are primary physiological regulators of water-electrolyte balance.
“Magnocellular AVP neurons in the PVN and SON release AVP both centrally and systemically in response to dehydration, hemorrhage, and stress and are known to be one of the primary physiological regulators of water-electrolyte balance (145).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [145]
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Stojiljković, A., Čupić, Ž., Maćešić, S. R., Ivanović-Šašić, A., & Mojović, M. (2025) · Royal Society Open Science · doi:10.1098/rsos.251323
- Authors
- Sivukhina, E. V., & Jirikowski, G. F.
- Affiliations
- Jena University Hospital (DE)
- Corresponding author
- Jirikowski, Gustav F.
- Venue
- Steroids
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 111
- Pages
- 21-28
- ISSN
- 0039-128X (ISSN-L)
- OpenAlex
- W2253922932
- Cited by
- 29
- References
- 114
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Steroids (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- magnocellular neurons, hypothalamo-neurohypophysial system, hypothalamic-pituitary-adrenal axis, vasopressin, oxytocin, paraventricular nucleus, supraoptic nucleus, corticotropin-releasing factor, glucocorticoids, corticosteroid-binding globulin, fluid and electrolyte balance, stress response, lactation, childbirth, reproductive behavior, neuroendocrine regulation, chronic disease pathogenesis
- MeSH terms
- Animals, Glucocorticoids, Humans, Hypothalamus, Oxytocin, Pituitary-Adrenal System, Vasopressins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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