The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
The effect of age, sex and level of intake of dietary fibre from wheat on large-bowel function in thirty healthy subjects
Open accessAbstract
1. To evaluate the effect of age, sex and level of intake on the colonic response to wheat fibre, thirty healthy volunteers aged 17–62 years (nineteen men, eleven women) recruited from a local industry, were divided into four groups and given a controlled diet for two 3-week periods. The diet contained white bread during one period or one of four different amounts of bran-enriched wholemeal bread during the other (30, 60, 110, 170 g/d). 2. Wide variation was observed between subjects in stool weight on the basal diet and in response to wheat fibre. Stepwise regression analysis showed that the variation in stool weight was significantly related to sex (t 4.0, P <0.001) but not to age, height, weight or energy:fibre intakes on the basal diet. Stool weight in men (162(SE 11) g/d) was approximately double that in women (83(SE 11) g/d). Transit time and stool weight were closely related and the effect of sex on stool weight could be explained entirely by differences in transit. 4. Faecal carbohydrate excretion increased with the addition of bran mainly due to increased amounts of cellulose and pentose (arabinose+xylose), whilst digestibility of dietary non-starch polysaccharide fell from 77.6 (SE 2.3)% on the white bread diet to 65.6 (SE 2.4)% with the added bran (t 7.4, P < 0.01, n26). 5. Faecal pH was more acid in men than in women and was related to methane production. Methane producers had higher faecal pH than non-producers (7.06 (SE 0.1 1) v. 6.65 (SE O.1)), lower stool weight (g/d; 93 (SE 12) v. 156 (SE 13)) and slower transit times (h; 84.6 (SE 11.7) v. 48.6 (SE 6.6)). 6. These studies show that, when on similar diets, women have much lower stool weights and slower transit times than men. Furthermore, within the range of amounts of wheat fibre used in this and other published work, stool weight increases in linear proportion to the dose of fibre added to the diet. Methane excretion in breath is associated in this group of subjects with slow transit time and high faecal pH.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Numerous experiments have found that constipated individuals have a higher abundance of methanogenic species in their intestinal microbiota, along with slower intestinal transit times and higher faecal pH [54-58].”
From Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota (2021) · cites this paper as [55]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1975) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/58.5.1085 · Cited by 20,078
Durnin, J. V. G. A., & Womersley, J. (1974) · British Journal Of Nutrition · doi:10.1079/bjn19740060 · Cited by 6,343
Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions
Burstein, M., Scholnick, H. R., & Morfin, R. F. (1970) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42943-8 · Cited by 2,500
Micro-Analysis in Medical Biochemistry
(1951) · JAMA · doi:10.1001/jama.1951.03670210069041 · Cited by 1,500
THE DETERMINATION OF SUGAR IN BLOOD AND SPINAL FLUID WITH ANTHRONE REAGENT
Roe, J. H. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71120-4 · Cited by 1,454
Standardization of hemoglobinometry II. The hemiglobincyanide method
Kampen, E.-J. V., & Zijlstra, W. G. (1961) · Clinica Chimica Acta · doi:10.1016/0009-8981(61)90145-0 · Cited by 1,101
EFFECT OF DIETARY FIBRE ON STOOLS AND TRANSIT-TIMES, AND ITS ROLE IN THE CAUSATION OF DISEASE
Burkitt, D. P., Walker, A. R. P., & Painter, N. S. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92974-1 · Cited by 1,033
Englyst, H. N., Wiggins, H. S., & Cummings, J. H. (1982) · The Analyst · doi:10.1039/an9820700307 · Cited by 856
Self-citationTriglycerides Determination after Enzymatic Hydrolysis
Wahlefeld, A. W. (1974) · Elsevier eBooks · doi:10.1016/b978-0-12-091304-6.50036-7 · Cited by 826
Mechanism of action of dietary fibre in the human colon
Stephen, A. M., & Cummings, J. H. (1980) · Nature · doi:10.1038/284283a0 · Cited by 503
Self-citation
Flagged first, then by citations
Research works printed but not linked: 7
- Walker, 1979, South African Medical Journal, 55, 495
- Roschlau, 1974, Zeitschrift für Klinische Chemie: Klinische Biochemie, 12, 403
- Stephen A. M. (1980). Dietary fibre and human colonic function. PhD Thesis, University of Cambridge.
- Brobst, 1966, Cereal Chemistry, 43, 35
- 1979, Morbidity Statistics from General Practice 1971–1972. 2nd National Study. Studies on Medical and Population Subjects no. 36
- Wootton, 1974, Microanalysis in Medical Biochemistry, 218
- Gear J. S. S. (1979). Epidemiological studies of the role of dietary fibre in the aetiology of disease. PhD Thesis, University of Oxford.
Cited by
Sorted by citations
Items 101–154 of 154
Mathers, J. C., & Fotso, J. M. (1994) · British Journal Of Nutrition · doi:10.1079/bjn19940128 · Cited by 17
Effects of Cellulose Supplementation on Fecal Consistency and Fecal Weight
Danjo, K., Sakamoto, J., Iwane, S., Tamura, K., Nakaji, S., Fukuda, S., Murakami, H., Shimoyama, T., Takahashi, I., & Umeda, T. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9938-6 · Cited by 16
de Wit, N. J. W., Esser, D., Siebelink, E., Fischer, A., Sieg, J., & Mes, J. J. (2019) · Food & Function · doi:10.1039/c8fo01649f · Cited by 17
Implications for sex-related issues in clinical pharmacology and biopharmaceutics
Mishra, A., Rajpoot, K., Agrawal, O. P., & Tekade, R. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814425-1.00019-x · Cited by 15
Effects of Extrinsic Wheat Fiber Supplementation on Fecal Weight; A Randomized Controlled Trial
Brandl, B., Lee, Y.-M., Dunkel, A., Hofmann, T. F., Hauner, H., & Skurk, T. (2020) · Nutrients · doi:10.3390/nu12020298 · Cited by 15
Grabitske, H. A., & Slavin, J. L. (2008) · Nutrition Today · doi:10.1097/01.nt.0000303353.44218.e9 · Cited by 15
Key, F. B., & Mathers, J. C. (1993) · British Journal Of Nutrition · doi:10.1079/bjn19930049 · Cited by 15
Gastro-enteric methane versus sulphate and volatile fatty acid production
Nollet, L. M. L., & Verstraete, W. (1996) · Environmental Monitoring and Assessment · doi:10.1007/bf00394045 · Cited by 14
Nakaji, S., Fukuda, S., Iwane, S., Murakami, H., TAMURA, K., Munakata, A., & Sugawara, K. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2002.t01-1-02899.x · Cited by 13
Silk, D. B. A. (1993) · Clinical Nutrition · doi:10.1016/s0261-5614(09)90017-6 · Cited by 13
Constipation: a physiological approach.
Thompson, W. (2000) · Canadian journal of gastroenterology = Journal canadien de gastroenterologie · doi:10.1155/2000/391807 · Cited by 12
Interrelationships between age, total dietary fiber intake and breath methane in humans
Fernandes, J., Wolever, T. M. S., & Rao, A. V. (2000) · Nutrition Research · doi:10.1016/s0271-5317(00)00184-6 · Cited by 11
OTSUKA, M., Satchithanandam, S., & Calvert, R. J. (1989) · Journal of Nutrition · doi:10.1093/jn/119.4.566 · Cited by 11
Increased Serum Cholesterol in Healthy Human Methane Producers Is Confounded by Age
Fernandes, J., Wolever, T. M. S., & Rao, A. V. (1998) · Journal of Nutrition · doi:10.1093/jn/128.8.1349 · Cited by 11
Whole Pulses and Pulse Fiber: Modulating Gastrointestinal Function and the Microbiome
Dahl, W. J., & Alvarez, M. M. (2019) · Springer eBooks · doi:10.1007/978-3-030-12763-3_7 · Cited by 10
Normal Physiology of the Gastrointestinal Tract and Gender Differences
Karlstadt, R. G., Hogan, D. L., & Foxx–Orenstein, A. E. (2004) · Principles of Gender-Specific Medicine · doi:10.1016/b978-012440905-7/50304-2 · Cited by 9
Whole cereal and legume seeds increase faecal short chain fatty acids compared to ground seeds.
Hovey, A. L., Jones, G. P., Devereux, H., & Walker, K. Z. (2003) · PubMed · Cited by 8
Preparation and characterization of a [14C]cellulose suitable for human metabolic studies
Walters, M. P., Kelleher, J., Findlay, J. M., & Srinivasan, S. T. (1989) · British Journal Of Nutrition · doi:10.1079/bjn19890012 · Cited by 8
Cuyper, A. D., Clauß, M., Lens, L., Strubbe, D., Zedrosser, A., Steyaert, S. M. J. G., Saravia, A. M., & Janssens, G. (2021) · Zoo Biology · doi:10.1002/zoo.21593 · Cited by 7
The physiological effects of cellulose in the human large intestine
Stephen, A. M. (1989) · Animal Feed Science and Technology · doi:10.1016/0377-8401(89)90100-4 · Cited by 7
Self-citationMetano no ar expirado de crianças com constipação crônica funcional
Soares, A. C. F., Tahan, S., Fagundes‐Neto, U., & de Morais, M. B. (2002) · Arquivos de Gastroenterologia · doi:10.1590/s0004-28032002000100012 · Cited by 7
Setia, S., & Gwee (2012) · International Journal of General Medicine · doi:10.2147/ijgm.s29011 · Cited by 6
Dietary Fibre in the Prevention and Treatment of Gastro-intestinal Disorders
Heaton, K. W. (1992) · ILSI human nutrition reviews · doi:10.1007/978-1-4471-1928-9_14 · Cited by 6
Ertl, V. M., Höring, M., Schött, H.-F., Blücher, C., Kjølbæk, L., Astrup, A. V., Burkhardt, R., & Liebisch, G. (2020) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-020-02416-y · Cited by 5
Johnson, I. T. (2012) · Wiley eBooks · doi:10.1002/9781119946045.ch8 · Cited by 6
Dufour-Lescoat, C., COZ, Y. L., Andrieux, C., & Szylit, O. (1995) · Food Hydrocolloids · doi:10.1016/s0268-005x(09)80189-6 · Cited by 4
Radiologische Methoden (Defäkographie, Transitmessung)
Goei, R., & Müller-Lissner, S. (1989) · Interdisziplinäre Gastroenterologie · doi:10.1007/978-3-642-74657-4_8 · Cited by 3
Managing Constipation and Its Risks in Parkinson’s Disease: Is There a Role for Dietary Fiber?
Beke, M., & Dahl, W. J. (2025) · Canadian Journal of Dietetic Practice and Research · doi:10.3148/cjdpr-2025-015 · Cited by 3
Biomarkers of Total Dietary Fiber Intake: A Challenge to Meet
Natella, F., Devirgiliis, C., Roselli, M., Sette, S., Bo’, C. D., Cioffi, I., Polito, A., & Canali, R. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf095 · Cited by 3
Romodanovsky, D. P., Goryachev, D. V., Хохлов, А. Л., & Miroshnikov, A. E. (2018) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2018-3.5.15 · Cited by 3
Drug Delivery to the Large Intestine and Rectum
(2000) · CRC Press eBooks · doi:10.1201/9780203483701.ch7 · Cited by 3
Authorised EU health claims for wheat bran fibre
Harland, J. I. (2015) · Elsevier eBooks · doi:10.1016/b978-1-78242-382-9.00006-2 · Cited by 3
Sebastian, A., Shanmuganathan, M. A. A., Tripathy, C., Chakravarty, S., & Ghosh, S. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01079 · Cited by 2
Al-Shagrawi, R. A., Al-Ojayan, M. O., Sadek, M. A., Al-Shayeb, I. E., & Al-Ruqaie, I. M. (1999) · Food Chemistry · doi:10.1016/s0308-8146(98)00208-8 · Cited by 2
Effect of Diet on Intestinal Function and Dysfunction
Heaton, K. W. (1989) · Springer eBooks · doi:10.1007/978-1-4684-5694-3_5 · Cited by 2
Potter, J. D., Sellers, T. A., & Rich, S. S. (1995) · Cancer biology and medicine · doi:10.1007/978-94-011-0677-1_3 · Cited by 2
Aoki, Y., Kawasoe, S., Kubozono, T., Yoshimoto, J., Kishi, M., Kanouchi, H., Suzuki, S., & Ohishi, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-95618-2 · Cited by 1
Larik, G. N. F., Canfora, E. E., van Schothorst, E. M., & Blaak, E. E. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2701495 · Cited by 1
Irritable bowel syndrome: Bacterial overgrowth—What’s known and what to do
Pimentel, M., & Lezcano, S. (2007) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-007-0036-z · Cited by 1
Bowel function of postmenopausal women: Effects of daily consumption of dried plum
Shamloufard, P., Kern, M., & Hooshmand, S. (2016) · International Journal of Food Properties · doi:10.1080/10942912.2016.1266498 · Cited by 1
Nakorn, C. N., Phadungsombut, N., Chuchome, T., & Wiwattanawongsa, K. (2013) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 1
Schindlbeck, N. E. (1989) · Interdisziplinäre Gastroenterologie · doi:10.1007/978-3-642-74657-4_6 · Cited by 1
THE EFFECTS OF POLYDEXTROSE AND SOLUBLE CORN FIBER ON LAXATION AND SATIETY IN HEALTHY HUMAN SUBJECTS
Timm, D. A. (2012) · University of Minnesota Digital Conservancy (University of Minnesota) · Cited by 1
James, W. P. T., & Ralph, A. (1989) · Springer eBooks · doi:10.1007/978-1-4471-1680-6_4 · Cited by 1
Tiempo de tránsito colónico en individuos normales de la Ciudad de México
Pérez, M. A. P., Santiago, C. C., Díaz, A. V., & Pazos, A. S. (2005)
Tinsley, J., Velarde, G., & DeLosSantos, M. (2013) · Springer eBooks · doi:10.1007/978-1-4471-5517-1_20
Zander, R., Hennig, A., & Gruhn, K. (1988) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/bf02021293
Schenck-Gustafsson, K. G., & von Euler, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-54960-6_14
Nitrogen contamination of groundwater by on-site sanitation
Hammoud, A. S. (2018) · Spiral (Imperial College London) · doi:10.25560/68470
Unbalance Glycometabolic in Elderly Woman None Diabetic COPD Patients
Ciarambino (2013) · Journal of Endocrinology and Metabolism · doi:10.4021/jem194e
Microbiota and Diseases Associated with the Digestive System
Martín-Rivas, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-65650-7_4 · Cited by 1
Diet and Gastrointestinal Symptoms in Patients with Prostate Cancer Treated with Radiotherapy
Pettersson, A. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Sex and Gender Differences in Drug Safety
Jeong, N., & Choi, N. (2026) · Springer eBooks · doi:10.1007/978-981-95-2070-1_7
Metadata
- Authors
- Stephen, A. M., Wiggins, H. S., Englyst, H. N., Cole, T. J., Wayman, B. J., & Cummings, J. H.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 1986-09
- Volume
- 56
- Issue
- 2
- Pages
- 349-361
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2162278126
- Cited by
- 154
- References
- 41
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 2 · 2013: 6 · 2012: 5
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Open Research (University of Surrey) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- dietary fiber, wheat bran, whole grain bread, colonic transit time, stool weight, sex differences, age effects, fecal pH, methane production, fecal water content
- MeSH terms
- Adolescent, Adult, Aging, Body Weight, Dietary Fiber, Eating, Feces, Female, Humans, Hydrogen-Ion Concentration, Intestine, Large, Lipids, Male, Methane, Middle Aged, Minerals, Sex Characteristics, Time Factors, Triticum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
