Cited by 120Regulation of Appetite and ObesityDiet, Metabolism, and DiseaseAdipose Tissue and Metabolism

Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats

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Iossa, Susanna, Lionetti, Lillà, Mollica, Maria P., Crescenzo, Raffaella, Botta, Monica, Barletta, Antonio, Liverini, Giovanna·2003·British Journal of Nutrition

Abstract

The changes in metabolic efficiency, body composition, and nutrient partitioning induced by high-fat feeding were evaluated in adult rats (90d of age). The alterations in serum free triiodothyronine, insulin, and leptin levels, as well as in hepatic and skeletal muscle metabolism, were also assessed. Rats were fed either a low- or a high-fat diet for 2 weeks. Relative to the low-fat feeding, energy intake and expenditure, as well as body-energy gain, lipid gain, and energetic efficiency, were increased by the high-fat feeding. Increased serum leptin levels accompanied these variations. A positive correlation between serum leptin levels and percentage of body fat was found in the rats fed the low- or high-fat diet, with a significant divergence between the slope of the regression lines. Furthermore, a negative correlation between serum leptin level and energy intake was found in the rats fed the low-fat diet, while a positive correlation was found in the rats fed the high-fat diet. Finally, the high-fat feeding decreased the hepatic and skeletal muscle mitochondrial oxidative capacity. It is concluded that, in adult rats, a nutritional factor such as a high level of fat in the diet induces obesity, leptin resistance, and impairment of mitochondrial capacity, all phenomena typical of unrestrained aged rats.

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Crossref · 10.1079/bjn2003000968

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  • There are reports on altered mitochondrial adaptations in skeletal muscle during development of insulin resistance in adults, as well as improvement in mitochondrial capacity to oxidize fat-derived substrates and increase in number.

    “There have also been reports on altered mitochondrial adaptations in skeletal muscle during the development of insulin resistance in adults (36, 37), as well as an improvement in mitochondrial capacity to oxidize fat-derived substrates and increase in number (38).”

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Authors
Iossa, S., Lionetti, L., Mollica, M. P., Crescenzo, R., Botta, M., Barletta, A., & Liverini, G.
Affiliations
University of Naples Federico II (IT)
Corresponding author
Liverini, Giovanna
Venue
British Journal of Nutrition
Published
2003-11
Volume
90
Issue
5
Pages
953-960
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
OpenAlex
W2155536232
Cited by
120
References
43
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 10 · 2016: 1 · 2015: 5 · 2014: 8 · 2013: 9 · 2012: 6
FWCI
1.19
Type
journal article
Language
en
Open access
Locations
  • British Journal Of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministero dell’Istruzione, dell’Università e della Ricerca (COFIN-2002)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
high-fat diet, metabolic efficiency, mitochondrial oxidative capacity, leptin, leptin resistance, obesity, energy expenditure, energy intake, body composition, nutrient partitioning, hepatic metabolism, skeletal muscle metabolism, triiodothyronine, insulin, aging, dietary fat
MeSH terms
Animals, Blood Glucose, Body Composition, Dietary Fats, Energy Metabolism, Fatty Acids, Nonesterified, Insulin, Liver, Male, Mitochondria, Mitochondria, Liver, Mitochondria, Muscle, Oxidation-Reduction, Triiodothyronine, Rats, Wistar, Muscle, Skeletal, Leptin, Rats

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