Effect of dietary methionine on plasma and liver cholesterol concentrations in rats and expression of hepatic genes involved in cholesterol metabolism
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Methionine has been shown to increase plasma cholesterol in animals. In the present study, mechanisms were investigated by which methionine could alter cholesterol metabolism. In the first experiment, forty growing rats were fed four casein-based diets differing in methionine content (2.6, 3.5, 4.5 or 6.0 g/kg) for 14 d. In the second experiment, isolated rat hepatocytes were incubated in media supplemented with 50, 100 or 200 micromol/l methionine. Dietary methionine tended to increase plasma homocysteine concentrations in the rats (P=0.058). A weak positive correlation between circulating homocysteine and plasma cholesterol was observed (R2 0.27, P<0.01). Rats fed 3.5 g/kg or more of methionine had higher concentrations of cholesterol in their plasma, in lipoprotein fractions of density (rho; kg/l) 1.006 1.063, and in liver than rats fed 2.6 g/kg methionine. Rats fed 6 g/kg methionine had a higher hepatic expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol-7alpha-hydroxylase than rats fed less methionine. The phosphatidylcholine:phosphatidylethanolamine ratio in rat liver increased with rising dietary methionine concentration; the relative mRNA concentrations of phosphatidylethanolamine N-methyltransferase and cystathionine beta-synthase remained unaffected. Hepatocytes incubated in media supplemented with 100 or 200 micromol/l methionine had a higher cholesterol synthesis than hepatocytes incubated in a medium supplemented with 50 micromol/l methionine; the LDL uptake in hepatocytes was independent of the methionine concentration of the medium. In conclusion, the present study suggests that dietary methionine induces hypercholesterolaemia at least in part via an enhanced hepatic cholesterol synthesis.
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Methionine supplementation causes the opposite and exerts a marked hyperlipidemic action.
“whereas methionine supplementation causes the opposite and exerts a marked hyperlipidemic action [19].”
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Cites
Reeves, P. G., Nielsen, F. H., & Fahey, G. C., Jr. (1993) · Journal of Nutrition · doi:10.1093/jn/123.11.1939 · Cited by 8,730 · see citing works
Chapter 4 Preparation of Isolated Rat Liver Cells
Seglen, P. O. (1976) · Methods in cell biology · doi:10.1016/s0091-679x(08)61797-5 · Cited by 5,297 · see citing works
Lipid extraction of tissues with a low-toxicity solvent
Hara, A., & Radin, N. S. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90046-5 · Cited by 2,566 · see citing works
Shimano, H., Yahagi, N., Amemiya-Kudo, M., Hasty, A. H., Osuga, J.-I., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Harada, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35832 · Cited by 691 · see citing works
Yao, Z. M., & Vance, D. E. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69166-5 · Cited by 618 · see citing works
Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans
Goldstein, J. L., Basu, S. K., Brunschede, G. Y., & Brown, M. S. (1976) · Cell · doi:10.1016/0092-8674(76)90258-0 · Cited by 613 · see citing works
Nutritional and hormonal factors influencing desaturation of essential fatty acids
Brenner, R. R. (1981) · Progress in Lipid Research · doi:10.1016/0163-7827(81)90012-6 · Cited by 548 · see citing works
Calcium-dependent Human Serum Homocysteine Thiolactone Hydrolase
Jakubowski, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.3957 · Cited by 399 · see citing works
Schuster, R. (1988) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)83096-0 · Cited by 340 · see citing works
Vester, B., & Rasmussen, K. D. (1991) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1991.29.9.549 · Cited by 338 · see citing works
Homocysteine Thiolactone: Metabolic Origin and Protein Homocysteinylation in Humans
Jakubowski, H. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.377s · Cited by 255 · see citing works
Butte, W. (1983) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)87931-0 · Cited by 250 · see citing works
Liscum, L., & Faust, J. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45483-x · Cited by 245 · see citing works
Soy Protein Peptides Regulate Cholesterol Homeostasis in Hep G2 Cells
Arnoldi, A., Kurowska, E. M., Carroll, K. K., Lovati, M. R., Manzoni, C., Gianazza, E., & Sirtori, C. R. (2000) · Journal of Nutrition · doi:10.1093/jn/130.10.2543 · Cited by 232 · see citing works
Soy Consumption and Cholesterol Reduction: Review of Animal and Human Studies
Carroll, K. K., & Kurowska, E. M. (1995) · Journal of Nutrition · doi:10.1093/jn/125.suppl_3.594s · Cited by 228 · see citing works
Soy consumption and cholesterol reduction: review of animal and human studies.
Carroll, K. K., & Kurowska, E. M. (1995) · PubMed · doi:10.1093/jn/125.3_suppl.594s · Cited by 211 · see citing works
Rapid fluorometric assay of LDL receptor activity by DiI-labeled LDL.
Stephan, Z. F., & Yurachek, E. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40759-x · Cited by 207 · see citing works
Plasma amino acids determined by liquid chromatography within 17 minutes
Terrlink, T., van Leeuwen, P. A., & Houdijk, A. P. J. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.2.245 · Cited by 198 · see citing works
An enzymatic assay for determining free and total cholesterol in tissue.
Hoff, J. L. D., Davidson, L. M., & Kritchevsky, D. (1978) · Clinical Chemistry · doi:10.1093/clinchem/24.3.433 · Cited by 136 · see citing works
Dietary Fiber-Rich Barley Products Beneficially Affect the Intestinal Tract of Rats
Dongowski, G., Huth, M., Gebhardt, E., & Flamme, W. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3704 · Cited by 128 · see citing works
Woo, C. W., Siow, Y. L., Pierce, G. N., Choy, P. C., Minuk, G. Y., Mymin, D., & Karmin, O. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00518.2004 · Cited by 118 · see citing works
Soybean Protein Diet and Plasma Cholesterol: From Therapy to Molecular Mechanisms
Sirtori, C. R., EVEN, R., & Lovati, M. R. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb38734.x · Cited by 91 · see citing works
Rozek, L. S., Hatsukami, T. S., Richter, R. J., Ranchalis, J., Nakayama, K. S., McKinstry, L. A., Gortner, D. A., Boyko, E. J., Schellenberg, G. D., Furlong, C. E., et al. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400489-jlr200 · Cited by 56 · see citing works
Dietary Protein and Lipid Metabolism: A Multifunctional Effecta
Sugano, M., & Koba, K. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb38736.x · Cited by 55 · see citing works
Intestinal lipids and lipoproteins in the human fetus: modulation by epidermal growth factor.
Levy, E. H., Thibault, L., & Ménard, D. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41383-5 · Cited by 55 · see citing works
Garda, H. A., & Brenner, R. R. (1985) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(85)90194-4 · Cited by 52 · see citing works
SUGIYAMA, K., Yamakawa, A., Kumazawa, A., & Saeki, S. (1997) · Journal of Nutrition · doi:10.1093/jn/127.4.600 · Cited by 51 · see citing works
Giroux, I., Kurowska, E. M., Freeman, D. J., & Carroll, K. K. (1999) · Journal of Nutrition · doi:10.1093/jn/129.10.1807 · Cited by 47 · see citing works
SUGIYAMA, K., Akachi, T., & Yamakawa, A. (1995) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(94)00017-g · Cited by 47 · see citing works
Marlett, J. A., & Fischer, M. H. (2002) · Journal of Nutrition · doi:10.1093/jn/132.9.2638 · Cited by 45 · see citing works
Localization of the PE methylation pathway and SR-BI to the canalicular membrane
Sehayek, E., Wang, R., Ono, J. G., Zinchuk, V. S., Duncan, E. M., Shefer, S., Vance, D. E., Ananthanarayanan, M., Chait, B. T., & Breslow, J. L. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200488-jlr200 · Cited by 43 · see citing works
SUGIYAMA, K., Kanamori, H., Akachi, T., & Yamakawa, A. (1996) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(95)00165-4 · Cited by 41 · see citing works
Eder, K., & Brandsch, C. (2002) · European Journal of Lipid Science and Technology · doi:10.1002/1438-9312(200201)104:1 · Cited by 36 · see citing works
Self-citationChromatographic analysis of phospholipids
Christie, W. W. (1985) · European Food Research and Technology · doi:10.1007/bf02425573 · Cited by 34 · see citing works
Giudetti, A. M., Beynen, A. C., Lemmens, A. G., Gnoni, G. V., & Geelen, M. J. H. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2003977 · Cited by 32 · see citing works
Tumor necrosis factor-alpha inhibits lipid and lipoprotein transport by Caco-2 cells
Mehran, M., Seidman, E. G., Marchand, R., Gurbindo, C., & Levy, E. H. (1995) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1995.269.6.g953 · Cited by 30 · see citing works
Biochemical controls of liver cholesterol biosynthesis
Ott, D. B., & Lachance, P. (1981) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.10.2295 · Cited by 28 · see citing works
SUGIYAMA, K., Kumazawa, A., Zhou, H., & Saeki, S. (1998) · Lipids · doi:10.1007/s11745-998-0201-2 · Cited by 28 · see citing works
Tanaka, K., & Sugano, M. (1989) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.35.323 · Cited by 25 · see citing works
Geelen, M. J. H., & Beynen, A. C. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000684 · Cited by 23 · see citing works
Oda, H., OKUMURA, Y., Hitomi, Y., Ozaki, K., Nagaoka, S., & Yoshida, A. (1989) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.35.333 · Cited by 21 · see citing works
Dietary Protein and Experimental Atherosclerosis
KRTTCHEVSKY, D. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb38733.x · Cited by 19 · see citing works
Ikeda, A., Imaizumi, K., & Sugano, M. (1993) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.57.1867 · Cited by 14 · see citing works
SAEKI, S., Kanauchi, O., & Kiriyama, S. (1990) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.36.supplementii_s125 · Cited by 8 · see citing works
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High Turnover Rates for Hydrogen Sulfide Allow for Rapid Regulation of Its Tissue Concentrations
Vitvitsky, V., Kabil, Ö., & Banerjee, R. V. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4310 · Cited by 191 · see citing works
Cholesterol-Lowering Activity of Tartary Buckwheat Protein
Zhang, C., Zhang, R., Li, Y. M., Liang, N. N., Zhao, Y., Zhu, H., He, Z., Liu, J., Hao, W., Jiao, R., et al. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b00066 · Cited by 99 · see citing works
Violi, J. P., Bishop, D., Padula, M. P., Steele, J. R., & Rodgers, K. J. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116018 · Cited by 92 · see citing works
Elshorbagy, A. K., Valdivia‐Garcia, M., Graham, I. M., dos Reis, R. P., Lúis, A. S., Smith, A. D., & Refsum, H. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.01.008 · Cited by 84 · see citing works
Cai, D., Jia, Y., Lu, J., Yuan, M., Sui, S., Song, H., & Zhao, R. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514002402 · Cited by 83 · see citing works
Wang, Z., Mai, K., Xu, W., Zhang, Y., Liu, Y., & Ai, Q. (2015) · Aquaculture · doi:10.1016/j.aquaculture.2015.12.019 · Cited by 82 · see citing works
Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats
Koladiya, R. U., Jaggi, A. S., Singh, N., & Sharma, B. (2008) · BMC Pharmacology · doi:10.1186/1471-2210-8-14 · Cited by 80 · see citing works
Sulfur-Containing Amino Acids and Lipid Metabolism
Blachier, F., Andriamihaja, M., & Blais, A. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa243 · Cited by 79 · see citing works
Hypolipidemic effect of dietary pea proteins: Impact on genes regulating hepatic lipid metabolism
Rigamonti, E., Parolini, C., Marchesi, M., Diani, E., Brambilla, S., Sirtori, C. R., & Chiesa, G. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900251 · Cited by 56 · see citing works
Brandsch, C., Shukla, A., Hirche, F., Stangl, G. I., & Eder, K. (2006) · Nutrition · doi:10.1016/j.nut.2006.06.009 · Cited by 55 · see citing works
Self-citationGessner, D. K., Schwarz, A., Meyer, S., Wen, G., Most, E., Zorn, H., Ringseis, R., & Eder, K. (2019) · The Journal of Nutrition · doi:10.1093/jn/nxy256 · Cited by 53 · see citing works
Self-citationMechanistic basis of hypermethioninemia
Schweinberger, B. M., & Wyse, Â. T. D. S. (2016) · Amino Acids · doi:10.1007/s00726-016-2302-4 · Cited by 40 · see citing works
Stearoyl-CoA Desaturase-1: Is It the Link between Sulfur Amino Acids and Lipid Metabolism?
Poloni, S., Blom, H. J., & Schwartz, I. V. D. (2015) · Biology · doi:10.3390/biology4020383 · Cited by 38 · see citing works
Lee, J., Jung, S., Kim, N., Shin, M., Ryu, D. H., & Hwang, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-13991-z · Cited by 37 · see citing works
Alimentary proteins, amino acids and cholesterolemia
Blachier, F., Lancha, A. H., Boutry, C., & Tomé, D. (2009) · Amino Acids · doi:10.1007/s00726-009-0239-6 · Cited by 36 · see citing works
Bhattacharyya, S., Sarkar, A., Dey, S. K., Jose, G. P., Mukherjee, A., & Sengupta, T. K. (2013) · Dalton Transactions · doi:10.1039/c3dt51296g · Cited by 33 · see citing works
Kakhki, R. A. M., Golian, A., & Zarghi, H. (2016) · British Poultry Science · doi:10.1080/00071668.2016.1173199 · Cited by 32 · see citing works
Parolini, C., Rigamonti, E., Marchesi, M., Busnelli, M., Cinquanta, P., Manzini, S., Sirtori, C. R., & Chiesa, G. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.12.004 · Cited by 32 · see citing works
Xu, H., Ren, M., Liang, H., Ge, X., Ji, K., Huang, D., Yu, H., & Wu, L. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737381 · Cited by 29 · see citing works
Kapoor, P., Ansari, M. N., & Bhandari, U. (2008) · PubMed · Cited by 29 · see citing works
Effects of dynamic feeding low and high methionine diets on egg quality traits in laying hens
Liu, Y., Lin, X., Zhou, X., Wan, D., Wang, Z., Wu, X., & Yin, Y. (2016) · Poultry Science · doi:10.3382/ps/pew398 · Cited by 29 · see citing works
Koladiya, R. U., Jaggi, A. S., Singh, N., & Sharma, B. (2009) · Eisei kagaku · doi:10.1248/jhs.55.215 · Cited by 28 · see citing works
Abachi, S., Pilon, G., Marette, A., Bazinet, L., & Beaulieu, L. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2052261 · Cited by 27 · see citing works
dl-methionine enrichment in diets fed to Atlantic salmon increases apparent digestibility
Espe, M., Liaset, B., Hevrøy, E. M., & El‐Mowafi, A. (2010) · Aquaculture Research · doi:10.1111/j.1365-2109.2010.02700.x · Cited by 25 · see citing works
Role of Oxytocin in deceleration of early atherosclerotic inflammatory processes in adult male rats.
Ahmed, M. A., & Elosaily, G. M. (2011) · Europe PMC (PubMed Central) · Cited by 25 · see citing works
Seiliez, I., Vélez, E. J., Lutfi, E., Dias, K., Plagnes‐Juan, E., Marandel, L., Panserat, S., Geurden, I., & Cassy, S. (2017) · Aquaculture · doi:10.1016/j.aquaculture.2017.01.010 · Cited by 25 · see citing works
Kumar, A., Pathak, R., Palfrey, H. A., Stone, K. P., Gettys, T. W., & Murthy, S. N. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-019-0422-z · Cited by 25 · see citing works
Cai, W., Liu, H., Han, D. H., Zhu, X., Jin, J., Yang, Y., & Xie, S. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2021.759086 · Cited by 24 · see citing works
Viggiano, A., Viggiano, E., Monda, M., Ingrosso, D., Perna, A. F., & Luca, B. D. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.048 · Cited by 24 · see citing works
Meyer, S., Gessner, D. K., Wen, G., Most, E., Liebisch, G., Zorn, H., Ringseis, R., & Eder, K. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801305 · Cited by 23 · see citing works
Self-citationStangl, G. I., Weiße, K., Dinger, C., Hirche, F., Brandsch, C., & Eder, K. (2007) · PubMed · Cited by 23 · see citing works
Self-citationKim, J.-S., Liu, L., Kant, S., Orlicky, D. J., Uppalapati, S. R., Margolis, A., Davenport, B., Morrison, T. E., Matsuda, J. L., McClelland, M., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.01.004 · Cited by 20 · see citing works
Wolf, N. M., Mueller, K., Hirche, F., Most, E., Pallauf, J., & Mueller, A. S. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510000899 · Cited by 20 · see citing works
Self-citationPlasma Cystathionine and Risk of Incident Stroke in Patients With Suspected Stable Angina Pectoris
Dhar, I., Svingen, G. F. T., Ueland, P. M., Lysne, V., Svenningsson, M. M., Tell, G. S., & Nygard, O. K. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.008824 · Cited by 19 · see citing works
Yang, L., & Kadowaki, M. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.1405 · Cited by 19 · see citing works
Hashemi, S. M., Loh, T. C., Foo, H. L., ZULKIFLI, I., & Bejo, M. H. (2014) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2014.05.008 · Cited by 13 · see citing works
Lee, J. H., Jun, H., Jia, Y., Kim, W., Choi, S., & Lee, S. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf202910u · Cited by 13 · see citing works
Insect Protein: A Sustainable and Healthy Alternative to Animal Protein?
Salter, A. M. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy315 · Cited by 12 · see citing works
Radtke, J., Schutkowski, A., Brandsch, C., Hirche, F., Hasenkopf, K., & Stangl, G. I. (2015) · Plant Foods for Human Nutrition · doi:10.1007/s11130-015-0481-x · Cited by 12 · see citing works
Self-citationMata-Sotres, J. A., Flores-Salas, C., Skrzynska, A. K., Tinajero, A., Araújo, B. C., & Viana, M. T. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737870 · Cited by 10 · see citing works
Wang, Y., Wang, P., Zhang, Q., Zhang, H., Li, Z., Liu, X., Kaur, L., & Kumar, M. (2020) · Pharmacognosy Magazine · doi:10.4103/pm.pm_438_19 · Cited by 10 · see citing works
The role of B12 deficiency and methionine synthase in methionine-dependent cancer cells
Husseiny, M. E., & Nilsson, R. (2025) · Cancer & Metabolism · doi:10.1186/s40170-025-00405-2 · Cited by 9 · see citing works
Marschall, M. J. M., Grundmann, S. M., Geßner, D. K., Wen, G., Most, E., Eder, K., & Ringseis, R. (2023) · Nutrients · doi:10.3390/nu15020287 · Cited by 9 · see citing works
Self-citationCoelho‐Júnior, H. J., Calvani, R., Picca, A., Tosato, M., Savera, G., Landi, F., & Marzetti, E. (2023) · Metabolites · doi:10.3390/metabo13030431 · Cited by 9 · see citing works
Mendoza-Nazar, P., Martínez, G. D. M., Herrera-Haro, J. G., Ruíz-Sesma, B., Bárcena-Gama, R., & Tarango-Arámbula, L. A. (2011) · Tropical Animal Health and Production · doi:10.1007/s11250-011-9956-4 · Cited by 9 · see citing works
Jia, Y., Ling, M., Zhang, L., Jiang, S., Sha, Y., & Zhao, R. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b03615 · Cited by 9 · see citing works
Aguillón, O., Mata-Sotres, J. A., D’Abramo, L. R., & Viana, M. T. (2020) · Aquaculture Nutrition · doi:10.1111/anu.13095 · Cited by 7 · see citing works
Kiraz, Z. K., Genç, S., Bekpınar, S., Ünlüçerçi, Y., Olgaç, V., Uysal, M., & Gürdöl, F. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2263-4 · Cited by 7 · see citing works
Veasey, S. C. (2009) · Contemporary clinical neuroscience · doi:10.1007/978-1-60327-342-8 · Cited by 7 · see citing works
Abdi, F., Mohammadzadeh, M., & Farhangi, M. A. (2024) · BMC Endocrine Disorders · doi:10.1186/s12902-024-01549-w · Cited by 6 · see citing works
Ouyang, Y., Zhou, L., Jin, Y., Hou, G.-F., Yang, P., Chen, M., & Tian, Z. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.03.069 · Cited by 6 · see citing works
Meyer, S., Schäfer, L., Röhrig, J., Maheshwari, G., Most, E., Zorn, H., Ringseis, R., Eder, K., & Gessner, D. K. (2020) · Nutrients · doi:10.3390/nu12040987 · Cited by 5 · see citing works
Self-citationMoradi, M., Chashnidel, Y., Abdollahi, A., Yansari, A. T., Khazari, B., & Mansouryar, M. (2020) · Theriogenology · doi:10.1016/j.theriogenology.2020.12.016 · Cited by 5 · see citing works
Reyes, V. C., Flores-Sánchez, J., de la Cruz, E. R., Vázquez-García, J. M., Hernández-Arteaga, S., Sims, R., Cavazos-Galindo, J. M., Mellado, M., & Rosales-Nieto, C. A. (2025) · Biology · doi:10.3390/biology14030237 · Cited by 4 · see citing works
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INFLUENCE OF METHIONINE ON MORPHOFUNCTIONAL CHANGES OF RAT LIVER PARENCHYMA
Yanko, R. V., Chaka, O. G., & Levashov, M. I. (2020) · Fìzìologìčnij žurnal · doi:10.15407/fz66.05.038 · Cited by 3 · see citing works
Islam, M., & Behura, S. K. (2023) · Placenta · doi:10.1016/j.placenta.2023.12.019 · Cited by 3 · see citing works
Coelho‐Júnior, H. J., Calvani, R., Picca, A., Tosato, M., Savera, G., Landi, F., & Marzetti, E. (2023) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02549-x · Cited by 2 · see citing works
An allostatic load domain‐specific metabolic profile in young adults: The African‐PREDICT study
Joubert, N., Mels, C. M. C., Louw, R., Chung, S. T., & Wentzel, A. (2026) · The Journal of Physiology · doi:10.1113/jp289807 · Cited by 1 · see citing works
Morphofunctional changes in the rat's liver of different ages after L-methionine administration
Yanko, R. V., Chaka, E., & Levashov, M. I. (2022) · Journal of Education Health and Sport · doi:10.12775/jehs.2022.12.01.010 · Cited by 1 · see citing works
Elgizawy, E. I., Fouda, A. A., & El-Domiaty, H. F. (2021) · Bulletin of Egyptian Society for Physiological Sciences · doi:10.21608/besps.2021.53026.1088 · Cited by 1 · see citing works
Treating Oxidative Neural Injury: Methionine Sulfoxide Reductase Therapy for Parkinson’s Disease
Wassef, R., Heinemann, S. H., & Hoshi, T. (2009) · Contemporary clinical neuroscience · doi:10.1007/978-1-60327-342-8_12
Shimada, R., & Ebihara, K. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1403886
Ahmed, M., Sead, M., Omran, O. M., & Said, H. (2007) · Bulletin of Egyptian Society for Physiological Sciences · doi:10.21608/besps.2007.37117
Jike, N., Hei, Z., Ma, W., Chen, Y., Zhang, Y., Sun, Y., Liu, T., Feng, W., & Rao, K. (2026) · Tropical Animal Health and Production · doi:10.1007/s11250-026-04938-6
The Methionine-Mitochondria Axis in Cancer: Metabolic Cross-Talk and Therapeutic Vulnerabilities
Shakil, M. S., & McBride, M. J. (2026) · Current Pharmacology Reports · doi:10.1007/s40495-026-00481-y
- Authors
- Hirche, F., Schröder, A., Knoth, B., Stangl, G. I., & Eder, K.
- Affiliations
- Martin Luther University Halle-Wittenberg (DE)
- Corresponding author
- Eder, K.
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2006-05
- Volume
- 95
- Issue
- 5
- Pages
- 879-888
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2001048848
- Cited by
- 68
- References
- 44
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- dietary methionine, hypercholesterolemia, serum cholesterol, hepatic cholesterol synthesis, homocysteine, HMGR, CYP7A1, phosphatidylethanolamine N-methyltransferase, cystathionine beta-synthase, LDL uptake, hepatocytes, lipoprotein fractions, hepatic gene expression
- MeSH terms
- Amino Acids, Animals, Bile Acids and Salts, Cells, Cultured, Cholesterol, Diet, Eating, Feces, Gene Expression Regulation, Homocysteine, Lipids, Liver, Male, Methionine, Phosphatidylcholines, Phosphatidylethanolamines, Receptors, LDL, RNA, Messenger, Weight Gain, Rats, Sprague-Dawley, Hepatocytes, Lipid Metabolism, Rats
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