Cited by 23Insect Utilization and EffectsDiet, Metabolism, and DiseaseLipid metabolism and biosynthesis

The Antisteatotic and Hypolipidemic Effect of Insect Meal in Obese Zucker Rats is Accompanied by Profound Changes in Hepatic Phospholipid and 1-Carbon Metabolism

Meyer, Sandra, Gessner, Denise K., Wen, Gaiping, Most, Erika, Liebisch, Gerhard, Zorn, Holger, Ringseis, Robert, Eder, Klaus·2019·Molecular Nutrition & Food Research

Abstract

Scope: The hypothesis is tested that insect meal, which has a low methionine content, reduces the hepatic phosphatidylcholine (PC):phosphatidylethanolamine (PE) ratio, which is a critical determinant of hepatic lipid synthesis, by decreasing availability of the methionine metabolite S‐adenosylmethionine (SAM). Methods and results: Obese rats (n = 24) are randomly divided into two groups (Obese Casein and Obese Insect) of 12 rats each. In addition, lean rats (n = 12) are used as control group (LC). Groups LC and OC receive a control diet with casein as protein source, whereas in the OI group, casein is replaced isonitrogenously by insect meal, which is found to be less digestible (–12% units). Plasma and liver concentrations of lipids and hepatic expression of lipid synthesizing genes are reduced in the OI group compared to the OC group. Plasma and liver concentration of PC and the PC:PE ratio are decreased in the OI group compared to the OC group, while hepatic concentration of SAM and the hepatic SAM:S‐adenosylhomocysteine (SAH) ratio is lower in the OI group than in the OC group. Conclusion: The decrease of the hepatic PC:PE ratio is probably a key mechanism explaining the pronounced antisteatotic and hypolipidemic action of insect meal in obese rats.

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Crossref · 10.1002/mnfr.201801305

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Authors
Meyer, S., Gessner, D. K., Wen, G., Most, E., Liebisch, G., Zorn, H., Ringseis, R., & Eder, K.
Affiliations
  • Justus-Liebig-Universität Gießen (DE)
  • University Hospital Regensburg (DE)
Corresponding author
Ringseis, Robert
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2019-02
Volume
63
Issue
8
Pages
e1801305-e1801305
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W2914002147
Cited by
23
References
77
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 1
FWCI
2.09
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
  • University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
  • Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
  • Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
Funders
Hessisches Ministerium für Wissenschaft und Kunst (LOEWE research center “Insect Biotechnology and)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect Utilization and Effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
insect meal, hypolipidemic effect, hepatic steatosis, hepatic lipid synthesis, phosphatidylcholine, phosphatidylethanolamine, S-adenosylmethionine, S-adenosylhomocysteine, methionine metabolism, one-carbon metabolism, obesity, casein replacement, protein sources
MeSH terms
Animals, Animal Feed, Carbon, Cholesterol, Energy Metabolism, Gene Expression Regulation, Hyperlipidemias, Liver, Male, Methionine, Obesity, Phosphatidylcholines, Phosphatidylethanolamines, Phospholipids, Rats, Zucker, Tenebrio, Lipid Metabolism

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