The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
New insight into butyrate metabolism
Open accessAbstract
Butyrate is a C 4 acid produced by microbial fermentation of carbohydrates and protein in the large intestine of all animal species. The factor of prime importance for the production rate of butyrate in the lower gut is type and levels of non-digestible carbohydrates entering the large intestine. It was previously believed that 85–90% of the butyrate produced in the gut was cleared when passing the gut epithelium, but recent studies with catheterised pigs have shown that the concentration of butyrate in the portal vein is strongly influenced by the production rate in the large intestine. Increased gut production of butyrate further raises the circulating level of butyrate. For good reason it is not possible with current technologies to perform direct measurements of the variation in the butyrate concentration in the portal vein of human subjects, but short-chain fatty acid levels in portal blood from sudden-death victims, subjects undergoing emergency surgery or planned surgery have indicated a higher gut production and absolute and relative concentration of butyrate in non-fasted as compared with fasted human subjects. However, despite an expected higher gut production of butyrate when feeding a high-fibre rye-bread-based diet as compared with a low-fibre wheat-bread-based diet, there was no difference in absolute or relative levels of butyrate in the peripheral blood of human subjects.
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“Butyrate is a short-chain fatty acid (SCFA) synthesized by anaerobes in the colon of animals through the fermentation of indigestible dietary fibers [17].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [17]
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Cites
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119
Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750
THE COLONIC EPITHELIUM IN ULCERATIVE COLITIS: AN ENERGY-DEFICIENCY DISEASE?
Roediger, W. E. W. (1980) · The Lancet · doi:10.1016/s0140-6736(80)91934-0 · Cited by 728
Fermentation in the human large intestine and the available substrates
Cummings, J. H., & Englyst, H. N. (1987) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/45.5.1243 · Cited by 490
Short chain fatty acid absorption by the human large intestine.
McNeil, N. I., Cummings, J. H., & James, W. P. T. (1978) · Gut · doi:10.1136/gut.19.9.819 · Cited by 454
Physiological and Clinical Aspects of Short-Chain Fatty Acids
Cummings, J. H., Rombeau, J. L., & 坂田, 隆. (2004) · Medical Entomology and Zoology · Cited by 313
Polysaccharide breakdown by mixed populations of human faecal bacteria
Englyst, H. N., Hay, S., & Macfarlane, G. T. (1987) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1987.tb02352.x · Cited by 297
Sites of organic acid production and absorption in gastrointestinal tract of the pig
Argenzio, R., & Southworth, M. (1975) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1975.228.2.454 · Cited by 269
Metabolism of volatile fatty acids by liver and portal-drained viscera in sheep
Bergman, E., & Wolff, J. E. (1971) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1971.221.2.586 · Cited by 237
Gastrointestinal effects of food carbohydrate
Cummings, J. H., & Englyst, H. N. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.4.938s · Cited by 236
Research works printed but not linked: 3
- Kristensen, 2001, ruminants Energy Metabolism in Animals, 277
- 1997, Food, Nutrition and the Prevention of Cancer: a Global Perspective.
- Cummings, 1989, International Symposium on Comparative Aspects of the Physiology of Digestion in Ruminant and Hindgut Fermenters, 76
Cited by
Sorted by citations
Items 101–134 of 134
Claus, R. (2006) · Cited by 4
Resistant starch, chronic kidney disease, and the gut microbiome: A mini‐review
Guo, J., Szacilo, A., & Kong, L. (2024) · Food Frontiers · doi:10.1002/fft2.474 · Cited by 3
Lippens, M., Huyghebaert, G., & Scicutella, N. (2006) · EPC 2006 - 12th European Poultry Conference, Verona, Italy, 10-14 September, 2006 · Cited by 3
Boroumand, B., Roomiani, L., Baboli, M. J., Mabodi, H., & Dezfulneghad, M. C. (2024) · Thalassas An International Journal of Marine Sciences · doi:10.1007/s41208-023-00640-8 · Cited by 3
Martín-Orúe, S. M., Manzanilla, E. G., Anguita, M., Fondevila, M., Martı́n, M., Mateu, E., & Martín-Orúe, S. M. (2009) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2009.05.011 · Cited by 3
Hirayama, K., Hashimoto, H., Takeshita, A., Rui, C.-S., Noguchi, S., Takezaki, Y., & Itoh, K. (2010) · Bioscience and Microflora · doi:10.12938/bifidus.29.135 · Cited by 2
Braz, D. B. (2008) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.11.2008.tde-14052008-113209 · Cited by 2
Stas, E. B., Chen, Y., Wolfenden, R., Woodworth, J. C., Goodband, R. D., Tokach, M. D., DeRouchey, J. M., & Gebhardt, J. T. (2025) · Journal of Animal Science · doi:10.1093/jas/skaf198 · Cited by 1
Hosseini, L., Farshbaf‐Khalili, A., Jazani, A. M., & Maghsoumi‐Norouzabad, L. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04740-5 · Cited by 1
Solverson, P. M., Albaugh, G. P., Debelo, H., Ferruzzi, M. G., Baer, D. J., & Novotny, J. A. (2023) · Nutrients · doi:10.3390/nu15071709 · Cited by 1
Gut Microbiota, Probiotics, Prebiotics and Colorectal Cancer
Walton, G., & Gibson, G. R. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-627-6_9 · Cited by 1
Formation of carboxylic acids in rats and humans given indigestible carbohydrates
Nilsson, U. J. (2006) · Cited by 1
Low Butyric Acid is Associated With Constipation in Geriatrics
Yusuf, F., Setia, M. D. M., Manik, K., & Muhsin, M. (2020) · Systematic Reviews in Pharmacy · doi:10.31838/srp.2020.8.83 · Cited by 1
Paßlack, N. (2010) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-12782 · Cited by 1
Metabolic Effects of Wholegrain Foods in Relation to Composition, Structure and Type of Food
Mykkänen, H. M., Kolehmainen, M., Bondia‐Pons, I., & Poutanen, K. S. (2011) · Wiley eBooks · doi:10.1002/9781444318456.ch14 · Cited by 1
Franco, L. G. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.74.2009.tde-26112009-112148 · Cited by 1
The gut in control of health and disease
van der Beek (2017) · Research Publications (Maastricht University) · doi:10.26481/dis.20171004cvdb · Cited by 1
Nilsson, U. J. (2006) · Lund University Publications (Lund University)
Heimann, E. (2014) · Lund University Publications (Lund University)
de Agricultura, E. S., & de Queiroz, L. (2007)
Puzio, I., PIEDRA, J. L. V., Kapica, M., & Bieko, M. (2008)
(2018) · Wiley eBooks · doi:10.1002/9781118829875.refs
Thibault, R., & Darmaun, D. (2007) · Springer eBooks · doi:10.1007/978-2-287-33475-7_26
Prebiotics and Synbiotics in Nile Tilapia Culture
Doan, H. V. (2023) · Applied environmental science and engineering for a sustainable future · doi:10.1007/978-3-031-38321-2_6
Iakhno, S., Umu, Ö. C. O., Håkenåsen, I. M., Åkesson, C. P., Mydland, L. T., Press, C. M., Sørum, H. R., & Øverland, M. (2020) · Figshare · doi:10.6084/m9.figshare.12257756
Iakhno, S., Umu, Ö. C. O., Håkenåsen, I. M., Åkesson, C. P., Mydland, L. T., Press, C. M., Sørum, H. R., & Øverland, M. (2020) · Figshare · doi:10.6084/m9.figshare.12257792
Iakhno, S., Umu, Ö. C. O., Håkenåsen, I. M., Åkesson, C. P., Mydland, L. T., Press, C. M., Sørum, H. R., & Øverland, M. (2020) · Figshare · doi:10.6084/m9.figshare.12257765
Iakhno, S., Umu, Ö. C. O., Håkenåsen, I. M., Åkesson, C. P., Mydland, L. T., Press, C. M., Sørum, H. R., & Øverland, M. (2020) · Figshare · doi:10.6084/m9.figshare.12257780
Iakhno, S., Umu, Ö. C. O., Håkenåsen, I. M., Åkesson, C. P., Mydland, L. T., Press, C. M., Sørum, H. R., & Øverland, M. (2020) · Figshare · doi:10.6084/m9.figshare.12257774
Iakhno, S., Umu, Ö. C. O., Håkenåsen, I. M., Åkesson, C. P., Mydland, L. T., Press, C. M., Sørum, H. R., & Øverland, M. (2020) · Figshare · doi:10.6084/m9.figshare.12257783
Iakhno, S., Umu, Ö. C. O., Håkenåsen, I. M., Åkesson, C. P., Mydland, L. T., Press, C. M., Sørum, H. R., & Øverland, M. (2020) · Figshare · doi:10.6084/m9.figshare.12257771
Iakhno, S., Umu, Ö. C. O., Håkenåsen, I. M., Åkesson, C. P., Mydland, L. T., Press, C. M., Sørum, H. R., & Øverland, M. (2020) · Figshare · doi:10.6084/m9.figshare.12257786
Zhang, W., Tao, A., Chen, X., Li, X. G., Zou, T., Chen, J., & You, J. (2026) · Antioxidants · doi:10.3390/antiox15070805
Metadata
- Authors
- Knudsen, K. E. B., Serena, A., Canibe, N., & Juntunen, K. S.
- Affiliations
- University of Eastern Finland (FI)
- Corresponding author
- Knudsen, Knud Erik Bach
- Venue
- Proceedings of the Nutrition Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2003-02
- Volume
- 62
- Issue
- 1
- Pages
- 81-86
- ISSN
- 0029-6651 (ISSN-L)
- 1475-2719
- OpenAlex
- W2117896755
- Cited by
- 134
- References
- 27
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 12 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 10 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 3
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of The Nutrition Society (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- butyrate metabolism, short-chain fatty acids, colonic fermentation, non-digestible carbohydrates, intestinal epithelium, portal vein, dietary fiber, rye bread, wheat bread, fasting
- MeSH terms
- Animals, Butyrates, Catheterization, Dietary Fiber, Fermentation, Humans, Intestinal Absorption, Intestine, Large, Proteins, Swine, Models, Animal, Carbohydrate Metabolism
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