Fermentation in the human large intestine and the available substrates
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Bacterial fermentation of indigestible dietary fibers produces the short-chain fatty acids butyrate, propionate, and acetate in the colon.
“In addition, bacterial fermentation of indigestible dietary fibers produces among the SCFAs, butyrate, propionate, and acetate in the colon (97).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [97]
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“Microbial fermentation of fruit and vegetable fiber is extensive (Cummings & Englyst, 1987), and thus contributes little to the fecal bulking needed for laxation.”
BackgroundThe Sweet Side of Constipation: Colonic Motor Dysfunction in Diabetes Mellitus
De Fano, M., Baluganti, S., Manco, M., Porcellati, F., Fanelli, C. G., & Bassotti, G. (2025) · Nutrients · doi:10.3390/nu17193038 · Cited by 4 · see citing works
- Authors
- Cummings, J. H., & Englyst, H. N.
- ORCID
- Cummings, J H
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1987-05
- Volume
- 45
- Issue
- 5
- Pages
- 1243-1255
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1845247865
- Cited by
- 490
- References
- 83
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 13 · 2020: 17 · 2019: 13 · 2018: 18 · 2017: 31 · 2016: 14 · 2015: 14 · 2014: 10 · 2013: 10 · 2012: 15
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- colonic fermentation, short-chain fatty acids, dietary fiber, gut microbiota
- MeSH terms
- Dietary Carbohydrates, Dietary Fiber, Dietary Proteins, Fermentation, Humans, Intestine, Large, Intestine, Small, Lignin, Polysaccharides, Starch
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