CoChat
Sign Up
Cited by 134Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyAnimal Nutrition and Physiology

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

New insight into butyrate metabolism

Open access
Knudsen, Knud Erik Bach, Serena, Anja, Canibe, Nuria, Juntunen, Katri S.·2003·Proceedings of the Nutrition Society
DOI 10.1079/pns2002212
Open this paper in CoChat — free accountOpen PDF

Abstract

Butyrate is a C 4 acid produced by microbial fermentation of carbohydrates and protein in the large intestine of all animal species. The factor of prime importance for the production rate of butyrate in the lower gut is type and levels of non-digestible carbohydrates entering the large intestine. It was previously believed that 85–90% of the butyrate produced in the gut was cleared when passing the gut epithelium, but recent studies with catheterised pigs have shown that the concentration of butyrate in the portal vein is strongly influenced by the production rate in the large intestine. Increased gut production of butyrate further raises the circulating level of butyrate. For good reason it is not possible with current technologies to perform direct measurements of the variation in the butyrate concentration in the portal vein of human subjects, but short-chain fatty acid levels in portal blood from sudden-death victims, subjects undergoing emergency surgery or planned surgery have indicated a higher gut production and absolute and relative concentration of butyrate in non-fasted as compared with fasted human subjects. However, despite an expected higher gut production of butyrate when feeding a high-fibre rye-bread-based diet as compared with a low-fibre wheat-bread-based diet, there was no difference in absolute or relative levels of butyrate in the peripheral blood of human subjects.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1079/pns2002212

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 3

  1. Kristensen, 2001, ruminants Energy Metabolism in Animals, 277
  2. 1997, Food, Nutrition and the Prevention of Cancer: a Global Perspective.
  3. Cummings, 1989, International Symposium on Comparative Aspects of the Physiology of Digestion in Ruminant and Hindgut Fermenters, 76

Cited by

Sorted by citations

See all 134

Related

See all

Metadata

Authors
Knudsen, K. E. B., Serena, A., Canibe, N., & Juntunen, K. S.
Affiliations
University of Eastern Finland (FI)
Corresponding author
Knudsen, Knud Erik Bach
ORCID
Venue
Proceedings of the Nutrition Society
Publisher
Cambridge University Press (CUP)
Published
2003-02
Volume
62
Issue
1
Pages
81-86
ISSN
  • 0029-6651 (ISSN-L)
  • 1475-2719
DOI
10.1079/pns2002212
OpenAlex
W2117896755
Cited by
134
References
27
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 12 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 10 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 3
FWCI
2.31
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 1493 d)
Locations
  • Proceedings of The Nutrition Society (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
butyrate metabolism, short-chain fatty acids, colonic fermentation, non-digestible carbohydrates, intestinal epithelium, portal vein, dietary fiber, rye bread, wheat bread, fasting
MeSH terms
Animals, Butyrates, Catheterization, Dietary Fiber, Fermentation, Humans, Intestinal Absorption, Intestine, Large, Proteins, Swine, Models, Animal, Carbohydrate Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review