The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Infection of orthopedic implants and the use of antibiotic-loaded bone cements: A review
Open accessAbstract
Infections by bacteria are a serious complication following orthopedic implant surgery, that can usually only be cured by removing the implant, since the biofilm mode of growth of infecting bacteria on an implant surface protects the organisms from the host immune system and antibiotic therapy. Over the past few decades, attempts have been made to prevent and cure orthopedic implant infections by incorporating antibiotics in polymethylmethacrylate bone cements, in primary and revision surgery. However, the clinical efficacy of antibiotic-releasing bone cements is not accepted by all and the long-term exposure to low doses from antibiotic-releasing bone cements in patients is strongly related to the emerging threat of antibiotic resistance in medicine today. In this article, we start by reviewing the mechanisms governing the formation of an infectious biofilm on orthopedic implant materials, the release mechanisms and properties of clinically-used, antibiotic-loaded bone cements. The clinical efficacy of antibiotic-loaded bone cements is evaluated analyzing separatedly the prophylactic and therapeutic uses of these products.
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Citations
Cites
The crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834
Gottenbos, B. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.1.7 · Cited by 587
Release of gentamicin from acrylic bone cement
Bunetel, L., Segui, A., Cormier, M., Percheron, E., & Langlais, F. (1989) · Clinical Pharmacokinetics · doi:10.2165/00003088-198917040-00006 · Cited by 123
van de Belt, H., Neut, D., van Horn, J. R., van der Mei, H. C., Schenk, W., & Busscher, H. J. (1999) · Nature Medicine · doi:10.1038/7330 · Cited by 55
Self-citation
Cited by
Campoccia, D., Montanaro, L., Speziale, P., & Arciola, C. R. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.005 · Cited by 392
The role of polymethylmethacrylate bone cement in modern orthopaedic surgery
Webb, J. C. J., & Spencer, R. F. (2007) · The Journal of Bone and Joint Surgery. British volume · doi:10.1302/0301-620x.89b7.19148 · Cited by 386
Romanò, C. L., Scarponi, S., Gallazzi, E., Romanò, D., & Drago, L. (2015) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-015-0294-5 · Cited by 311
Backgrounds of antibiotic-loaded bone cement and prosthesis-related infection
Hendriks, J. G. E., van Horn, J. R., van der Mei, H. C., & Busscher, H. J. (2004) · Biomaterials · doi:10.1016/s0142-9612(03)00554-4 · Cited by 291
Self-citationTan, H., Peng, Z., Li, Q., Xu, X., Guo, S., & Tang, T. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.084 · Cited by 223
Metadata
- Authors
- Belt, H. V. D., Neut, D., Schenk, W., Horn, J. R. V., Mei, H. C. V. D., & Busscher, H. J.
- Venue
- Acta Orthopaedica Scandinavica
- Published
- 2001-01
- Volume
- 72
- Issue
- 6
- Pages
- 557-571
- ISSN
- 0001-6470 (ISSN-L)
- OpenAlex
- W1998322069
- Cited by
- 343
- References
- 4
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- gold
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- Belt, H. V. D., Neut, D., Schenk, W., Horn, J. R. V., Mei, H. C. V. D., & Busscher, H. J. (2001). Infection of orthopedic implants and the use of antibiotic-loaded bone cements: A review. Acta Orthopaedica Scandinavica. https://doi.org/10.1080/000164701317268978
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