The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
Cellular responses to nanoparticles: Target structures and mechanisms
Abstract
Nanotechnology makes use of the special surface properties of extremely small particles. In this rapidly growing field, many different materials are produced for a multitude of diverse applications. Possible adverse health effects of these materials however are so far scarcely investigated and are therefore a special task of toxicology. Although strategies for risk assessment have been suggested, the authors of the current review emphasize the fact that on the cellular, subcellular and molecular levels, interactions between nanoparticles (NP) and target cells relevant for the induction of possible adverse health effects are poorly understood. On the basis of existing literature, the potentially most relevant cellular target sites of NP as well as the so far known major molecular events specifically induced by these xenobiotics are reviewed. Starting with NP uptake across the cell membrane, mechanisms of generation of reactive oxygen species and the activation of redox-sensitive signalling cascades are described. Besides the cell membrane, mitochondria and cell nucleus are considered as major cell compartments relevant for possible NP-induced toxicity. Finally, an integrated research protocol is proposed to identify fundamental cellular responses to NP in order to complement current toxicological screening strategies with a mechanism-based approach.
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Cites
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Cited by
McClements, D. J., & Rao, J. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.559558 · Cited by 1,630
Sharifi, S., Behzadi, S., Laurent, S., Laird Forrest, M., Stroeve, P., & Mahmoudi, M. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15188f · Cited by 1,460
Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review
Malhotra, N., Lee, J.-S., Liman, R. A. D., Ruallo, J. M. S., Villaflores, O. B., Ger, T.-R., & Hsiao, C.-D. (2020) · Molecules · doi:10.3390/molecules25143159 · Cited by 470
Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge
Stone, V., Miller, M. R., Clift, M. J. D., Elder, A., Mills, N. L., Møller, P., Schins, R. P. F., Vogel, U., Kreyling, W. G., Alstrup Jensen, K., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp424 · Cited by 370
Self-citationPotential biological fate of ingested nanoemulsions: Influence of particle characteristics
McClements, D. J., & Xiao, H. (2012) · Food Funct. · doi:10.1039/c1fo10193e · Cited by 331
Metadata
- Authors
- Unfried, K., Albrecht, C., Klotz, L.-O., Von Mikecz, A., Grether-Beck, S., & Schins, R. P. F.
- Venue
- Nanotoxicology
- Publisher
- Informa UK Limited
- Published
- 2007-01
- Volume
- 1
- Issue
- 1
- Pages
- 52-71
- ISSN
- 1743-5390 (ISSN-L)
- 1743-5404
- OpenAlex
- W2062430935
- Cited by
- 503
- References
- 148
- FWCI
- 15.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Unfried, K., Albrecht, C., Klotz, L.-O., Von Mikecz, A., Grether-Beck, S., & Schins, R. P. F. (2007). Cellular responses to nanoparticles: Target structures and mechanisms. Nanotoxicology. https://doi.org/10.1080/00222930701314932
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
