The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults
Abstract
In an effort to increase our knowledge of the optimal use of serum cystatin C and creatinine as glomerular filtration rate (GFR) markers, these variables, as well as lean tissue mass and GFR, were determined in a population of 42 healthy young adults (men and women with normal GFR). Dual-energy X-ray absorptiometry and measurement of the plasma clearance of iohexol were used to measure lean tissue mass and GFR, respectively. Serum creatinine was significantly correlated to lean tissue mass (r=0.65; p < 0.0001) but not to GFR (1/creatinine vs. GFR: r=0.11; p=0.106). In contrast, serum cystatin C correlated with GFR (1/cystatin C vs. GFR: r=0.32; p=0.0387), especially in men (1/cystatin C vs. GFR: r=0.64; p=0.0055), but not to lean tissue mass. These results might explain previous observations that serum cystatin C seems to be a better marker for GFR than serum creatinine, particularly for individuals with small to moderate decreases in GFR. However, the results also show that the serum concentrations of both creatinine and cystatin C are determined not only by GFR, but also by other factors. Since these additional factors differ for cystatin C and creatinine, it seems justified to use serum creatinine and cystatin C in conjunction to estimate GFR, at least until it is known in what situations serum creatinine or cystatin C is the preferable marker.
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Cites
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Self-citationRenal handling of radiolabelled human cystatin C in the rat
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Self-citationGALLBLADDER INERTIA IN CŒLIAC DISEASE
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Self-citationRAPID EVALUATION OF CREATININE CLEARANCE
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Cited by
Estimating glomerular filtration rate from serum creatinine and cystatin C
Inker, L. A., Schmid, C. H., Tighiouart, H., Eckfeldt, J. H., Feldman, H. I., Greene, T., Kusek, J. W., Manzi, J., Van Lente, F., Zhang, Y. L., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1114248 · Cited by 4,102
Cystatin C as a marker of GFR—history, indications, and future research
Filler, G., Bökenkamp, A., Hofmann, W., Le Bricon, T., Martínez-Brú, C., & Grubb, A. (2005) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2004.09.025 · Cited by 734
Self-citationRisch, L., Herklotz, R., Blumberg, A., & Huber, A. R. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.11.2055 · Cited by 343
Biochemistry and Clinical Role of Human Cystatin C
Mussap, M., & Plebani, M. (2004) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360490504934 · Cited by 313
Effect of large weight reductions on measured and estimated kidney function
von Scholten, B. J., Persson, F., Svane, M. S., Hansen, T. W., Madsbad, S., & Rossing, P. (2017) · BMC Nephrology · doi:10.1186/s12882-017-0474-0 · Cited by 52
Metadata
- Authors
- Vinge, E., Lindergård, B., Nilsson–Ehle, P., & Grubb, A.
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 1999-01
- Volume
- 59
- Issue
- 8
- Pages
- 587-592
- ISSN
- 0036-5513 (ISSN-L)
- 1502-7686
- OpenAlex
- W2138901511
- Cited by
- 265
- References
- 13
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vinge, E., Lindergård, B., Nilsson–Ehle, P., & Grubb, A. (1999). Relationships among serum cystatin C, serum creatinine, lean tissue mass and glomerular filtration rate in healthy adults. Scandinavian Journal of Clinical and Laboratory Investigation. https://doi.org/10.1080/00365519950185076
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