Cited by 78Electrospun Nanofibers in Biomedical ApplicationsBone Tissue Engineering MaterialsSilk-based biomaterials and applications

Dose-Dependent effects of gamma irradiation on the materials properties and cell proliferation of electrospun polycaprolactone tissue engineering scaffolds

Augustine, Robin, Saha, Abhijit, Jayachandran, V. P., Thomas, Sabu, Kalarikkal, Nandakumar·2015·International Journal of Polymeric Materials and Polymeric Biomaterials

Abstract

Electrospun membranes of polycaprolactone are widely used for biomedical applications such as wound dressings and tissue engineering scaffolds. It is important to sterilize this material using the most accepted method, the gamma irradiation. In this study, the authors evaluated the sterilizability of electrospun polycaprolactone membranes with gamma radiation of varying doses. The irradiated materials were assessed for the changes in morphology, crystallinity, surface degradation, hydrophilicity, mechanical property, sterility, and the cell proliferation. The results demonstrate that electrospun polycaprolactone can be effectively sterilized by gamma irradiation, however a higher dose of radiation affects the materials properties. The irradiated membranes showed improved hydrophilicity and fibroblast cell proliferation.

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Crossref · 10.1080/00914037.2014.977900

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Authors
Augustine, R., Saha, A., Jayachandran, V. P., Thomas, S., & Kalarikkal, N.
Affiliations
  • Mahatma Gandhi University (IN)
  • UGC DAE Consortium for Scientific Research (IN)
  • Pushpagiri Medical College (IN)
Corresponding author
  • Thomas, Sabu
  • Kalarikkal, Nandakumar
Venue
International Journal of Polymeric Materials and Polymeric Biomaterials
Published
2015-01-13
Volume
64
Issue
10
Pages
526-533
ISSN
  • 0091-4037 (ISSN-L)
  • 1563-535X
OpenAlex
W2050896830
Cited by
78
References
33
Citations by year
2026: 2 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 4 · 2021: 7 · 2020: 12 · 2019: 9 · 2018: 2 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 3
FWCI
2.05
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Polymeric Materials (publishedVersion)
  • UpSpace Institutional Repository (University of Pretoria) (submittedVersion)
Funders
The authors acknowledge Department of Biotechnology (DBT), Government of India, New Delhi, for the financial support through MSUB IPLSARE program. Funding from UGC- SAP, DST-FIST, DST-Nanomission, and SAARD-KSCSTE are also gratefully acknowledged.
Topics
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Keywords
polycaprolactone, gamma irradiation, sterilization, electrospun membranes, tissue engineering scaffolds, radiation dose dependence, crystallinity, surface degradation, hydrophilicity, mechanical properties, fibroblast proliferation, sterility

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