Dose-Dependent effects of gamma irradiation on the materials properties and cell proliferation of electrospun polycaprolactone tissue engineering scaffolds
Abstract
Electrospun membranes of polycaprolactone are widely used for biomedical applications such as wound dressings and tissue engineering scaffolds. It is important to sterilize this material using the most accepted method, the gamma irradiation. In this study, the authors evaluated the sterilizability of electrospun polycaprolactone membranes with gamma radiation of varying doses. The irradiated materials were assessed for the changes in morphology, crystallinity, surface degradation, hydrophilicity, mechanical property, sterility, and the cell proliferation. The results demonstrate that electrospun polycaprolactone can be effectively sterilized by gamma irradiation, however a higher dose of radiation affects the materials properties. The irradiated membranes showed improved hydrophilicity and fibroblast cell proliferation.
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- Authors
- Augustine, R., Saha, A., Jayachandran, V. P., Thomas, S., & Kalarikkal, N.
- Affiliations
- Mahatma Gandhi University (IN)
- UGC DAE Consortium for Scientific Research (IN)
- Pushpagiri Medical College (IN)
- Corresponding author
- Thomas, Sabu
- Kalarikkal, Nandakumar
- Venue
- International Journal of Polymeric Materials and Polymeric Biomaterials
- Publisher
- Informa UK Limited
- Published
- 2015-01-13
- Volume
- 64
- Issue
- 10
- Pages
- 526-533
- ISSN
- 0091-4037 (ISSN-L)
- 1563-535X
- OpenAlex
- W2050896830
- Cited by
- 78
- References
- 33
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 4 · 2021: 7 · 2020: 12 · 2019: 9 · 2018: 2 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 3
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Polymeric Materials (publishedVersion)
- UpSpace Institutional Repository (University of Pretoria) (submittedVersion)
- Funders
- The authors acknowledge Department of Biotechnology (DBT), Government of India, New Delhi, for the financial support through MSUB IPLSARE program. Funding from UGC- SAP, DST-FIST, DST-Nanomission, and SAARD-KSCSTE are also gratefully acknowledged.
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- polycaprolactone, gamma irradiation, sterilization, electrospun membranes, tissue engineering scaffolds, radiation dose dependence, crystallinity, surface degradation, hydrophilicity, mechanical properties, fibroblast proliferation, sterility
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