Construction of collagen/nanocrystalline cellulose based-hydrogel scaffolds: Synthesis, characterization, and mechanical properties evaluation
Abstract
Tissue defects were treated by invasive processes such as implanting the scaffold to the defected area. Hydrogel scaffolds with the well-defined internal structure are significant for tissue engineering. In this work, preparation and characterization of hydrogels based on collagen and modified nanocrystalline cellulose (CNCs) have been reported. The surface morphology of hydrogels with different ratios of CNCs has been determined. The effects of polymer ratio on the resulting hydrogels, such as pore morphology, swelling ratio, degradation rate and mechanical properties were examined for a possible non-aggressive tissue engineering application. Subsequently, studies on cytotoxicity of hydrogels to fibroblasts have been defined.
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An increase in hydrophilic groups of hydrocolloids leads to a higher swelling ratio of hydrogel scaffolds.
“As supported, Ghorbani and Roshangar [47] also found that the increase in hydrophilic groups of hydrocolloids led to a higher swelling ratio of hydrogel scaffolds.”
From Amidated Pectin/Nanocellulose Hybrid Cryogel System with a pH-Responsive Release Profile for Small Intestinal Delivery (2025) · cites this paper as [47]
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Feng, S., Laurén, P., Zini, J., Gounani, Z., Bi, J., Yi, J., & Laaksonen, T. (2025) · Gels · doi:10.3390/gels11090700 · Cited by 5 · see citing works
“As supported, Ghorbani and Roshangar [47] also found that the increase in hydrophilic groups of hydrocolloids led to a higher swelling ratio of hydrogel scaffolds.”
- Authors
- Ghorbani, M., & Roshangar, L.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Corresponding author
- Ghorbani, Marjan
- Venue
- International Journal of Polymeric Materials and Polymeric Biomaterials
- Publisher
- Informa UK Limited
- Published
- 2019-11-27
- Volume
- 70
- Issue
- 2
- Pages
- 142-148
- ISSN
- 0091-4037 (ISSN-L)
- 1563-535X
- OpenAlex
- W2991455168
- Cited by
- 38
- References
- 33
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 7
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Polymeric Materials (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Advanced Cellulose Research Studies
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- collagen, cellulose nanocrystals, hydrogel scaffolds, tissue engineering, mechanical properties, swelling ratio, degradation rate, pore morphology, cytotoxicity, fibroblasts, polymer ratio
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