Cited by 39Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsNuclear Receptors and Signaling

Rifampicin Decreases Neuroinflammation to Maintain Mitochondrial Function and Calcium Homeostasis in Rotenone-Treated Zebrafish

Yurtsever, İlknur, Üstündağ, Ünsal Veli, Ünal, İsmail, Ateş, Perihan Seda, Emekli-Alturfan, Ebru·2022·Drug and Chemical Toxicology

Abstract

Among the mechanisms underlying Parkinson's disease, many pathogenic mechanisms are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, and neuroinflammation. Calcium is very important for neuronal and glial cells, neurodegenerative disease mechanisms are closely related to disturbed calcium homeostasis. Recent studies strongly support the role of inflammation in nigrostriatal degeneration in PD. In recent years, Rifampicin, a macrocyclic antibiotic has been shown to have a protective effect on neurons. This study aims to evaluate the effects of rifampicin in the experimental PD model induced by rotenone in zebrafish focusing on the relationship between calcium-dependent mitochondrial dysfunction and inflammation. Adult zebrafish were exposed to rotenone and rifampicin for 3 weeks. Locomotor activity was determined as the total distance that the zebrafish traveled for 5 min. Neuroinflammation and PD-related gene expressions were determined by RT-PCR. Mitochondrial calcium levels were determined using inductively coupled plasma-optical emission spectrometry (ICP-OES). Gamma synuclein, Park 7, Sigma-1 receptor expressions were determined by Western Blot. Our results show that rifampicin may be effective in reducing neuroinflammation, which may be an effective strategy to reduce mitochondrial dysfunction due to impaired calcium homeostasis in PD.

Integrity signals

Registry

Crossref · 10.1080/01480545.2020.1846549

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yurtsever, İ., Üstündağ, Ü. V., Ünal, İ., Ateş, P. S., & Emekli-Alturfan, E.
Affiliations
  • Istanbul Medipol University (TR)
  • Marmara University (TR)
  • Faculty of Dentistry, Department of Basic Medical Sciences, Marmara University
Corresponding author
Yurtsever, İlknur
Venue
Drug and Chemical Toxicology
Published
2020-11-13
Volume
45
Issue
4
Pages
1544-1551
ISSN
  • 0148-0545 (ISSN-L)
  • 1525-6014
OpenAlex
W3104756285
Cited by
39
References
45
Citations by year
2026: 1 · 2025: 7 · 2024: 6 · 2023: 11 · 2022: 9 · 2021: 5
FWCI
2.70
Type
journal article
Language
en
Open access
closed
Locations
  • Drug and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • Dspace Repository (Marmara Üniversitesi) (submittedVersion)
Funders
Marmara University Scientific Research and Project Commission (SAG-C-DRP-241018-0572)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
rifampicin, Parkinson's disease, neuroinflammation, mitochondrial dysfunction, calcium homeostasis, rotenone, zebrafish, nigrostriatal degeneration, locomotor activity, gamma-synuclein, DJ-1, sigma-1 receptor, neuroprotection
MeSH terms
Neuroinflammatory Diseases, Animals, Calcium, Homeostasis, Inflammation, Mitochondria, Rifampin, Rotenone, Zebrafish, Oxidative Stress, Neurodegenerative Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review