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SPERM OXIDATIVE STRESS AND THE EFFECT OF AN ORAL VITAMIN E AND SELENIUM SUPPLEMENT ON SEMEN QUALITY IN INFERTILE MEN
Abstract
Numerous studies have reported beneficial effects of antioxidant drugs on semen quality, but there is no well-defined therapeutical protocol in male infertility. This study aimed to test the effects of vitamin E and selenium supplementation on lipid peroxidation and on sperm parameters. The study included 54 voluntary and infertile men who produced semen samples for spermiogram and for spectrophotometric measurement of a lipid peroxidation marker, the malondialdehyde (MDA), and produced blood samples for high-performance liquid chromatography assessment of serum vitamin E level. The trial was randomized and open. Twenty-eight men were supplemented daily by vitamin E (400 mg) and selenium (225 microg), during 3 months. The remaining 26 patients received vitamin B (4,5 g/day) for the same duration. Only 20 patients achieved their treatment and returned for control analysis. MDA concentrations in sperm were much less than in seminal plasma and motility and viability were inversely correlated with semen MDA levels. In contrast to vitamin B supplementation, vitamin E and selenium supplementation produced a significant decrease in MDA concentrations and an improvement of sperm motility. The results confirm the protective and beneficial effects of vitamin E and selenium on semen quality and advocate their use in male infertility treatment.
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Citations
Cited by
Oxidative stress and male infertility—a clinical perspective
Tremellen, K. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn004 · Cited by 1,507
Selenium in human health and disease
Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3275 · Cited by 1,330
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007176.pub2 · Cited by 924
Lifestyle factors and reproductive health: taking control of your fertility
Sharma, R., Biedenharn, K. R., Fedor, J. M., & Agarwal, A. (2013) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-11-66 · Cited by 845
Antioxidant Systems and Oxidative Stress in the Testes
Aitken, R. J., & Roman, S. D. (2008) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.1.1.6843 · Cited by 834
Metadata
- Authors
- KESKES-AMMAR, L., FEKI-CHAKROUN, N., REBAI, T., SAHNOUN, Z., GHOZZI, H., HAMMAMI, S., ZGHAL, K., FKI, H., DAMAK, J., & BAHLOUL, A.
- Venue
- Archives of Andrology
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 49
- Issue
- 2
- Pages
- 83-94
- ISSN
- 0148-5016 (ISSN-L)
- OpenAlex
- W2093635222
- Cited by
- 385
- References
- 0
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: SPERM OXIDATIVE STRESS AND THE EFFECT OF AN ORAL VITAMIN E AND SELENIUM SUPPLEMENT ON SEMEN QUALITY IN INFERTILE MEN. https://app.cochat.ai/papers/10.1080/01485010390129269
- The paper
- KESKES-AMMAR, L., FEKI-CHAKROUN, N., REBAI, T., SAHNOUN, Z., GHOZZI, H., HAMMAMI, S., ZGHAL, K., FKI, H., DAMAK, J., & BAHLOUL, A. (2003). SPERM OXIDATIVE STRESS AND THE EFFECT OF AN ORAL VITAMIN E AND SELENIUM SUPPLEMENT ON SEMEN QUALITY IN INFERTILE MEN. Archives of Andrology. https://doi.org/10.1080/01485010390129269
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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