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Antioxidant and Antiproliferative Activities of Anthocyanin/Ellagitannin-Enriched Extracts From Syzygium cumini L. (Jamun, the Indian Blackberry)
Open accessAbstract
Colored fruits, particularly berries, are highly chemoprotective because of their antioxidant, antiproliferative, and antiinflammatory activities. We report the cancer chemoprotective potential of Syzygium cumini L., commonly known as jamun or Indian blackberry. Anthocyanins and other polyphenolics were extracted with acidic ethanol and enriched by amberlite XAD7/HP20 (1:1). The pulp powder was found to contain 0.54% anthocyanins, 0.17% ellagic acid/ellagitannins, and 1.15% total polyphenolics. Jamun seed contained no detectable anthocyanins but had higher amounts of ellagic acid/ellagitannins (0.5%) and total polyphenolics (2.7%) than the pulp powder. Upon acid hydrolysis, the pulp extract yielded 5 anthocyanidins by HPLC: malvidin (44.4%), petunidin (24.2%), delphinidin (20.3%), cyanidin (6.6%), and peonidin (2.2%). Extracts of both jamun pulp (1,445 ± 64 μmol of trolox equivalent (TE)/g) and seeds (3,379 ± 151 μM of TE/g) showed high oxygen radical absorbance capacity. Their high antioxidant potential was also reflected by 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)- and 2,2-diphenyl-1-picrylhydrazyl-scavenging and ferrous ion-chelating activities. We also analyzed antiproliferative activity of jamun extracts against human lung cancer A549 cells. The hydrolyzed pulp and seed extracts showed significant antiproliferative activity. However, unhydrolyzed extracts showed much less activity. These data showed that in addition to 5 anthocyanidins, jamun contains appreciable amounts of ellagic acid/ellagitannins, with high antioxidant and antiproliferative activities.
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Citations
Cites
The Haber–Weiss reaction and mechanisms of toxicity
Kehrer, J. P. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00231-6 · Cited by 1,418 · cited 1×
“, resveratrol) have been shown for their ability to compete with ferrozine for ferrous ion in solution (40).”
BackgroundA Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding
Perron, N. R., & Brumaghim, J. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9043-x · Cited by 1,370
Cited by
Health benefits of anthocyanins and molecular mechanisms: Update from recent decade
Li, D., Wang, P., Luo, Y., Zhao, M., & Chen, F. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1030064 · Cited by 489
“…Hagiwara et al., 2001; Bobe et al., 2006; Lala et al., 2006; Srivastava et al., 2007; Lim et al., 2013), blood cancer (Tsai et al., 2014), cervical cancer (Rugin a et al., 2012), lung cancer (Aqil et al., 2012), fibrosarcoma (Filipiak et al., 2014), and metastatic melanoma (Bunea et al., 2013).”
BackgroundEffects of anthocyanins on the prevention and treatment of cancer
Lin, B., Gong, C., Song, H., & Cui, Y. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13627 · Cited by 435
Zhao, P., Li, X., Yang, Q., Lu, Y., Wang, G., Yang, H., Dong, J., & Zhang, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1038802 · Cited by 43
Jamun (Syzygium cumini (L.) Skeels) seed bioactives and its biological activities: A review
Kumar, M., Hasan, M., Lorenzo, J. M., Dhumal, S., Nishad, J., Rais, N., Verma, A., Changan, S., Barbhai, M. D., Radha, et al. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.102109 · Cited by 28
Metadata
- Authors
- Aqil, F., Gupta, A., Munagala, R., Jeyabalan, J., Kausar, H., Sharma, R. J., Singh, I. P., & Gupta, R. C.
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 2012-04
- Volume
- 64
- Issue
- 3
- Pages
- 428-438
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- OpenAlex
- W2003904109
- Cited by
- 188
- References
- 2
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Aqil, F., Gupta, A., Munagala, R., Jeyabalan, J., Kausar, H., Sharma, R. J., Singh, I. P., & Gupta, R. C. (2012). Antioxidant and Antiproliferative Activities of Anthocyanin/Ellagitannin-Enriched Extracts From Syzygium cumini L. (Jamun, the Indian Blackberry). Nutrition and Cancer. https://doi.org/10.1080/01635581.2012.657766
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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