CoChat
Sign Up
Cited by 183Oral Health Pathology and TreatmentHead and Neck Cancer StudiesSeaweed-derived Bioactive Compounds

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Evaluation of chemoprevention of oral cancer with spirulina fusiformis

Mathew, Babu, Sankaranarayanan, Rengaswamy, Nair, Padmanabhan P., Varghese, Cherian, Somanathan, Thara, Amma, B. Padmavathy, Amma, N. Sreedevi, Nair, Madhavan Krishnan·1995·Nutrition and Cancer
DOI 10.1080/01635589509514407
Open this paper in CoChat — free account

Abstract

The blue-green microalgae Spirulina, used in daily diets of natives in Africa and America, have been found to be a rich natural source of proteins, carotenoids, and other micronutrients. Experimental studies in animal models have demonstrated an inhibitory effect of Spirulina algae on oral carcinogenesis. Studies among preschool children in India have demonstrated Spirulina fusiformis (SF) to be an effective source of dietary vitamin A. We evaluated the chemopreventive activity of SF (1 g/day for 12 mos) in reversing oral leukoplakia in pan tobacco chewers in Kerala, India. Complete regression of lesions was observed in 20 of 44 (45%) evaluable subjects supplemented with SF, as opposed to 3 of 43 (7%) in the placebo arm (p < 0.0001). When stratified by type of leukoplakia, the response was more pronounced in homogeneous lesions: complete regression was seen in 16 of 28 (57%) subjects with homogeneous leukoplakia, 2 of 8 with erythroplakia, 2 of 4 with verrucous leukoplakia, and 0 of 4 with ulcerated and nodular lesions. Within one year of discontinuing supplements, 9 of 20 (45%) complete responders with SF developed recurrent lesions. Supplementation with SF did not result in increased serum concentration of retinol or beta-carotene, nor was it associated with toxicity. This is the first human study evaluating the chemopreventive potential of SF. More studies in different settings and different populations are needed for further evaluation.

Overview

Integrity signals

Registry

Crossref · 10.1080/01635589509514407

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 15 references

Research works printed but not linked: 1

  1. Seshadri CV, 1992, Spirulina

Cited by

Sorted by citations

Items 101–183 of 183

Related

See all

Metadata

Authors
Mathew, B., Sankaranarayanan, R., Nair, P. P., Varghese, C., Somanathan, T., Amma, B. P., Amma, N. S., & Nair, M. K.
Affiliations
  • Regional Cancer Center, Thiruvananthapuram (IN)
  • Centre international de recherche sur le cancer (FR)
  • Beltsville Human Nutrition Research Center (US)
  • Armed Forces Medical College (IN)
ORCID
Venue
Nutrition and Cancer
Publisher
Informa UK Limited
Published
1995-01
Volume
24
Issue
2
Pages
197-202
ISSN
  • 0163-5581 (ISSN-L)
  • 1532-7914
DOI
10.1080/01635589509514407
OpenAlex
W2221089757
Cited by
183
References
15
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 11 · 2021: 9 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 10 · 2014: 6 · 2013: 8 · 2012: 7
FWCI
2.21
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition and Cancer (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Keywords
oral cancer chemoprevention, oral leukoplakia, tobacco chewing, dietary supplementation, retinol, beta-carotene, micronutrients, lesion regression, recurrence
MeSH terms
Adult, Cyanobacteria, Carotenoids, Female, Food, Fortified, Humans, India, Leukoplakia, Oral, Male, Middle Aged, Mouth Neoplasms, Remission Induction, Vitamin A, beta Carotene

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review