The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Antitumorigenic effect of a mammalian lignan precursor from flaxseed
Abstract
Secoisolariciresinol diglycoside (SD), a mammalian lignan precursor found in high-fiber foods, was isolated from flaxseed and tested for effects on mammary tumorigenesis in rats fed a high-fat (20%) diet. Ingestion of purified SD at 1.5 mg/day for 20 weeks starting 1 week after treatment with the carcinogen dimethylbenzanthracene resulted in a 37% reduction (p < 0.05) in the number of tumors per tumor-bearing rat and a 46% reduction (p < 0.05) in the number of tumors per tumor-bearing rat and a 46% reduction (p < 0.05) in the number of tumors per number of rats in each group. Urinary mammalian lignan excretion significantly increased (p < 0.0001) with SD treatment, indicating the conversion of SD to mammalian lignans. No enlargement or gross abnormalities of the major organs were observed in the SD-treated rats. This study showed, for the first time, that SD has an antitumor effect when provided at the early promotion stage of tumorigenesis and may contribute to the health benefits of high-fiber foods.
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Cites
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Cited by
Interaction between Phenolics and Gut Microbiota: Role in Human Health
Selma, M. V., Espín, J. C., & Tomás-Barberán, F. A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902107d · Cited by 1,324
Whole grain phytochemicals and health
Liu, R. H. (2007) · Journal of Cereal Science · doi:10.1016/j.jcs.2007.06.010 · Cited by 988
Nutrition and cancer: A review of the evidence for an anti-cancer diet
Donaldson, M. S. (2004) · Nutrition Journal · doi:10.1186/1475-2891-3-19 · Cited by 699
Tripoli, E., Giammanco, M., Tabacchi, G., Di Majo, D., Giammanco, S., & La Guardia, M. (2005) · Nutrition Research Reviews · doi:10.1079/nrr200495 · Cited by 631
Owen, R. W., Mier, W., Giacosa, A., Hull, W. E., Spiegelhalder, B., & Bartsch, H. (2000) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(00)00061-2 · Cited by 577
Metadata
- Authors
- Thompson, L. U., Seidl, M. M., Rickard, S. E., Orcheson, L. J., & Fong, H. H. S.
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 1996-01
- Volume
- 26
- Issue
- 2
- Pages
- 159-165
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- OpenAlex
- W2062843200
- Cited by
- 262
- References
- 27
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thompson, L. U., Seidl, M. M., Rickard, S. E., Orcheson, L. J., & Fong, H. H. S. (1996). Antitumorigenic effect of a mammalian lignan precursor from flaxseed. Nutrition and Cancer. https://doi.org/10.1080/01635589609514472
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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