The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Mono-Iodoacetate-Induced Histologic Changes in Subchondral Bone and Articular Cartilage of Rat Femorotibial Joints: An Animal Model of Osteoarthritis
Abstract
Osteoarthritis (OA) is a degenerative joint disease characterized by joint pain and a progressive loss of articular cartilage. Studies to elucidate the pathophysiology of OA have been hampered by the lack of a rapid, reproducible animal model that mimics both the histopathology and symptoms associated with the disease. Injection of mono-iodoacetate (MIA), an inhibitor of glycolysis, into the femorotibial joint of rodents promotes loss of articular cartilage similar to that noted in human OA. Here, we describe the histopathology in the subchondral bone and cartilage of rat (Wistar) knee joints treated with a single intra articular injection of MIA (1 mg) and sacrificed at 1, 3, 5, 7, 14, 28, and 56 days postinjection. Histologically, the early time points (days 1—7) were characterized by areas of chondrocyte degeneration/necrosis sometimes involving the entire thickness of the articular cartilage in the tibial plateaus and femoral condyles. Changes to the subchondral bone, as evidenced by increased numbers of osteoclasts and osteoblasts, were noted at by day 7. By 28 days, there was focal fragmentation and collapse of bony trabeculae with fibrosis and increased osteoclastic activity. By 56 days there were large areas of bone remodeling evidenced by osteoclastic bone resorption and newly formed trabeculae with loss of marrow hematopoietic cells. Subchondral cysts and subchondral sclerosis were present in some rats. In conclusion, intra-articular injection of MIA induces loss of articular cartilage with progression of subchondral bone lesions that mimic those of OA. This model offers a rapid and minimally invasive method to reproduce OA-like lesions in a rodent species.
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Cites
The Association of Bone Marrow Lesions with Pain in Knee Osteoarthritis
Felson, D. T., Chaisson, C. E., Hill, C. L., Totterman, S. M. S., Gale, M. E., Skinner, K. M., Kazis, L., & Gale, D. R. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-7-200104030-00007 · Cited by 1,002
The role of the chondrocyte in osteoarthritis
Goldring, M. B. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200009)43:9<1916::aid-anr2>3.0.co;2-i · Cited by 713
Bove, S. E., Calcaterra, S. L., Brooker, R. M., Huber, C. M., Guzman, R. E., Juneau, P. L., Schrier, D. J., & Kilgore, K. S. (2003) · Osteoarthritis and Cartilage · doi:10.1016/s1063-4584(03)00163-8 · Cited by 503
Self-citationHonore, P., Luger, N. M., Sabino, M. A. C., Schwei, M. J., Rogers, S. D., Mach, D. B., O'keefe, P. F., Ramnaraine, M. L., Clohisy, D. R., & Mantyh, P. W. (2000) · Nature Medicine · doi:10.1038/74999 · Cited by 498
Guingamp, C., Gegout‐Pottie, P., Philippe, L., Terlain, B., Netter, P., & Gillet, P. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400917 · Cited by 412
A rat model of bone cancer pain
Medhurst, S. J., Walker, K., Bowes, M., Kidd, B. L., Glatt, M., Muller, M., Hattenberger, M., Vaxelaire, J., O'Reilly, T., Wotherspoon, G., et al. (2002) · Pain · doi:10.1016/s0304-3959(01)00437-7 · Cited by 311
Animal models of arthritis: relevance to human disease.
Bendele, A., Mccomb, J., Gould, T., Mcabee, T., Sennello, G., Chlipala, E., & Guy, M. (1999) · Toxicologic Pathology · doi:10.1177/019262339902700125 · Cited by 293
Osteoarthritis: diagnosis and therapeutic considerations.
Hinton, R., Moody, R. L., Davis, A., & Thomas, S. F. (2002) · PubMed · Cited by 211
Osteoprotegerin diminishes advanced bone cancer pain.
Luger, N. M., Honoré, P., Sabino, M., Schwei, M. J., Rogers, S. D., Mach, D. B., Clohisy, D. R., & Mantyh, P. W. (2001) · PubMed · Cited by 195
Janusz, M. J., Hookfin, E. B., Heitmeyer, S. A., Woessner, J. F., Freemont, A. J., Hoyland, J. A., Brown, K. K., Hsieh, L. C., Almstead, N. G., De, B., et al. (2001) · Osteoarthritis and Cartilage · doi:10.1053/joca.2001.0472 · Cited by 193
Cited by
Kraus, V. B., Huebner, J. L., DeGroot, J., & Bendele, A. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.04.015 · Cited by 1,771
Bove, S. E., Calcaterra, S. L., Brooker, R. M., Huber, C. M., Guzman, R. E., Juneau, P. L., Schrier, D. J., & Kilgore, K. S. (2003) · Osteoarthritis and Cartilage · doi:10.1016/s1063-4584(03)00163-8 · Cited by 503
Self-citationHe, Y., Li, Z., Alexander, P. G., Ocasio-Nieves, B. D., Yocum, L., Lin, H., & Tuan, R. S. (2020) · Biology · doi:10.3390/biology9080194 · Cited by 380
Yao, B. B., Hsieh, G. C., Frost, J. M., Fan, Y., Garrison, T. R., Daza, A. V., Grayson, G. K., Zhu, C. Z., Pai, M., Chandran, P., et al. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707568 · Cited by 140
Takahashi, I., Matsuzaki, T., Kuroki, H., & Hoso, M. (2018) · PLOS ONE · doi:10.1371/journal.pone.0196625 · Cited by 110
Metadata
- Authors
- Guzman, R. E., Evans, M. G., Bove, S., Morenko, B., & Kilgore, K.
- Venue
- Toxicologic Pathology
- Publisher
- SAGE Publications
- Published
- 2003-10
- Volume
- 31
- Issue
- 6
- Pages
- 619-624
- ISSN
- 0192-6233 (ISSN-L)
- 1533-1601
- OpenAlex
- W2117040516
- Cited by
- 461
- References
- 17
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Guzman, R. E., Evans, M. G., Bove, S., Morenko, B., & Kilgore, K. (2003). Mono-Iodoacetate-Induced Histologic Changes in Subchondral Bone and Articular Cartilage of Rat Femorotibial Joints: An Animal Model of Osteoarthritis. Toxicologic Pathology. https://doi.org/10.1080/01926230390241800
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
