Adolescent menstrual characteristics as predictors of gynaecological health
Abstract
Ina sample of 54 women who have participated in a longitudinal study since birth there is a significant relationship between adolescent menstrual characteristics and gynaecological health as measured by GYNDEX (Gardner 1982) in the second and third decades postmenarche. The menstrual characteristics were recorded in health histories taken in the 1940s as part of a yearly evaluation of growth, development and health status. Using stepwise multiple regression analysis, the measures of regularity and dysmenorrhoea in adolescence explain 46% of the variation in GYNDEX from 11 to 20 years postmenarche (P less than 0.001). These variables are still significant predictors 21 to 30 years postmenarche, explaining 26% of the variance (P less than 0.005). The risk of having poor gynaecological health (high GYNDEX) is greatly increased for women experiencing both dysmenorrhoea and irregularity in the first few years postmenarche.
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Follow-up of a different group of unselected healthy adolescents for 12 years showed tracking of androgen levels into adulthood, and higher adolescent levels were associated with lower fertility.
“Follow-up of a different group of unselected healthy adolescents for 12 years showed tracking of androgen levels into adulthood; higher levels in adolescence were associated with lower fertility, suggesting evolving PCOS [59]”
From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [59]
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- Authors
- Gardner, J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Gardner, J.
- Venue
- Annals of Human Biology
- Publisher
- Informa UK Limited
- Published
- 1983-01
- Volume
- 10
- Issue
- 1
- Pages
- 31-40
- ISSN
- 0301-4460 (ISSN-L)
- 1464-5033
- OpenAlex
- W2012533020
- Cited by
- 46
- References
- 30
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Human Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- dysmenorrhea, menstrual irregularity, menarche, long-term predictors, women's health, longitudinal cohort
- MeSH terms
- Adolescent, Adult, Age Factors, Child, Child, Preschool, Dysmenorrhea, Female, Health Status, Humans, Infant, Infant, Newborn, Longitudinal Studies, Menarche, Menstruation, Menstruation Disturbances, Statistics as Topic
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