The DOI matches its Crossref record; 69 of the 71 references it cites were found in a registry or an index.
Formulation, characterization and evaluation of minocycline hydrochloride loaded polyurethane/collagen nanofibers via electrospinning as wound dressings
Abstract
Objective It was aimed to formulate minocyline.HCI loaded electrospun polyurethane/collagen (PU/Col) and polyurethane/collagen/polycaprolactone (PU/Col/PCL) nanofibers are intended for use as a wound dressing. Methods:The effect of polymer ratio and addition of PCL on the morphology, diameter, drug delivery, encapsulation efficiency, mechanical properties, antibacterial activity against Escherichia coli and Staphylococcus aureus, cytotoxicity, cell adhesion and proliferation were investigated. 3-(4,5-dimethyldiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to test the cytotoxicity of the nanofibers on the human dermal fibroblast (HDF) cell line. Cell proliferation/adhesion was also determined by imaging HDF cells seeded on mats with scanning electron microscopy/fluorescence microscopy. Results:All nanofibers were bead-free and smooth in the diameter range of 866.7-882.4 nm. They had favorable encapsulation efficiency (≥79.3%), controlled drug release up to 24 hours and did not have cytotoxic effects. Although collagen was preferred for cell adhesion and proliferation, its spinnability and mechanical properties were poor. While PU improved the spinnability of collagen, its mechanical properties also enhanced with the addition of PCL. Nevertheles, all mats led to favorable cell adhesion and proliferation. All the nanofibers had antimicrobial activity against Escherichia coli and Staphylococcus aureus. Conclusion:In conclusion, PU/Col and PU/Col/PCL nanofiber mats, which had favorable encapsulation efficiency, controlled drug release and antibacterial activity at least 24 hours, cell viability, proliferation, adhesion, mechanical properties to be used as wound dressing, were successfully prepared.
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Rajendiran, S., & Deivanayagam, P. (2025) · Polymers for Advanced Technologies · doi:10.1002/pat.70481 · Cited by 6
Bezelya, A., Küçüktürkmen, B., Böncü, T. E., & Bozkır, A. (2025) · Polymers for Advanced Technologies · doi:10.1002/pat.70250 · Cited by 5
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Development, characterization and evaluation of baicalein loaded niosome and niosomal gel
Böncü, T. E., Kan, D., Yücel, Ç., & İlgün, S. (2025) · Journal of Research in Pharmacy · doi:10.12991/jrespharm.1734549 · Cited by 2
Self-citationWang, X., Liu, P., Chen, X., Zhou, H., Jiang, T., Gao, P., & Kuang, X. (2026) · ACS Applied Bio Materials · doi:10.1021/acsabm.6c00068
Metadata
- Authors
- Eren Boncu, T., Yücel, Ç., Ceylan, A., Cadir, M., & Sahmetlioglu, E.
- Affiliations
- Department of Pharmaceutical Technology, Erciyes University, Kayseri, Turkey
- Erciyes University (TR)
- Technology Research and Application Center, Erciyes University, Kayseri, Turkey
- Department of Basic Sciences of Engineering, Kayseri University, Kayseri, Turkey
- Venue
- Drug Development and Industrial Pharmacy
- Publisher
- Informa UK Limited
- Published
- 2024-10-02
- Volume
- 50
- Issue
- 10
- Pages
- 892-906
- ISSN
- 0363-9045 (ISSN-L)
- 1520-5762
- OpenAlex
- W4404109292
- Semantic Scholar
- f4129f8bba97bb4fad25c33d18b0aa49ee35ee60
- Cited by
- 5
- References
- 71
- Citations by year
- 2026: 1 · 2025: 4
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Development and Industrial Pharmacy (publishedVersion)
- PubMed (publishedVersion)
- Erciyes University - AVESIS (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- minocycline hydrochloride, electrospinning, wound dressings, polycaprolactone, antibacterial activity, Escherichia coli, Staphylococcus aureus, controlled drug release, encapsulation efficiency, cytotoxicity, human dermal fibroblasts, cell adhesion and proliferation, mechanical properties
- MeSH terms
- Anti-Bacterial Agents, Bandages, Cell Adhesion, Cell Line, Collagen, Escherichia coli, Fibroblasts, Humans, Polyesters, Polyurethanes, Staphylococcus aureus, Wound Healing, Drug Delivery Systems, Cell Proliferation, Nanofibers, Drug Liberation
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- CoChat. (2026). Citation check: Formulation, characterization and evaluation of minocycline hydrochloride loaded polyurethane/collagen nanofibers via electrospinning as wound dressings. https://app.cochat.ai/papers/10.1080/03639045.2024.2426581
- The paper
- Eren Boncu, T., Yücel, Ç., Ceylan, A., Cadir, M., & Sahmetlioglu, E. (2024). Formulation, characterization and evaluation of minocycline hydrochloride loaded polyurethane/collagen nanofibers via electrospinning as wound dressings. Drug Development and Industrial Pharmacy. https://doi.org/10.1080/03639045.2024.2426581
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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