The health effects of vitamin C supplementation: A review
Abstract
A comprehensive review of the literature indicates that populations with long-term consumption of higher than RDA levels of vitamin C (> or = 60 mg/day) from foods and/or supplements have reduced risks of cancer at several sites, cardiovascular disease, and cataracts. The safety of higher than RDA intakes of vitamin C is confirmed in eight placebo-controlled, double-blind studies and six non-placebo clinical trials in which up to 10,000 mg of vitamin C was consumed daily for up to 3 years. There are no clinical data which suggest that vitamin C's enhancement of non-heme iron absorption in individuals with low iron status could be a critical factor in the possible increased risk of heterozygous hemochromatosis-related cardiovascular disease. In fact, the cumulative data do not confirm that iron status is related to risk of cardiovascular disease. Moreover, higher than RDA intakes of vitamin C have been associated with several indices of lowered cardiovascular disease risk including increases in HDL, and decreases in LDL oxidation, blood pressure and cardiovascular mortality.
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Adverse effects of vitamin C, even at doses of 10 to 20 g/day, have not been convincingly demonstrated.
“The adverse effects of vitamin C, even at doses of 10 to 20 g/day, have not been convincingly demonstrated [150].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [150]
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References 151 · Cited by 150
- Authors
- Bendich, A., & Langseth, L.
- Affiliations
- Hoffman La-Roche Inc., Paramus, New Jersey 07652, USA.
- Venue
- Journal of the American College of Nutrition
- Publisher
- Informa UK Limited
- Published
- 1995-04
- Volume
- 14
- Issue
- 2
- Pages
- 124-136
- ISSN
- 0731-5724 (ISSN-L)
- 1541-1087
- OpenAlex
- W2078013408
- Cited by
- 150
- References
- 151
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 2
- FWCI
- 16.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American College of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- vitamin C supplementation, vitamin C, cancer risk, cardiovascular disease, cataract, nonheme iron absorption, iron status, hemochromatosis, cardiovascular mortality, HDL cholesterol, LDL oxidation, blood pressure
- MeSH terms
- Iron Deficiencies, Ascorbic Acid, Cardiovascular Diseases, Cataract, Female, Humans, Iron, Male, Neoplasms
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