Protective Effects of Dietary Soy Isoflavones against UV-Induced Skin-Aging in Hairless Mouse Model
Abstract
Objective This study investigated the anti-aging effects of dietary isoflavones on photoaged hairless mouse skin. Methods Female hairless mice were administered soy isoflavone extract orally and irradiated with UV light for four weeks. The effects of the isoflavones on the skin appearance, collagen deposition and epidermal thickness in the UV-damaged mouse skin were measured using bioengineering and histochemical methods. In addition, the influence of the isoflavones on the collagen metabolism in the UVB-irradiated human skin fibroblasts was also investigated. Results In the isoflavone treated group, the skin had a better appearance and less wrinkling than that of the control group. Additionally, the amount of collagen deposition was higher in the isoflavone group. In the human fibroblast cells, the amount of procollagen de novo synthesized did not increase after isoflavone treatment and/or UV irradiation. However, the increase in the expression of the metalloproteinases (MMPs) as a result of UV irradiation was suppressed by the isoflavone treatment. Conclusions It appears that isoflavones had an anti-aging effect on the UV-damaged hairless mice model, which is partly due to the inhibitory effects on UV-induced MMP-1 expression and the subsequent collagen degradation.
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Oral administration of soy isoflavone extract in a hairless mouse model protects against UV-B-induced skin aging.
“Another study investigated that oral administration of soy isoflavone extract in a hairless mouse model protects UV-B-induced skin aging (Kim et al. 2004).”
From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Kim et al. 2004
Cites
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
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Photoaging: mechanisms and repair
Rabe, J. H., Mamelak, A. J., McElgunn, P. J. S., Morison, W. L., & Sauder, D. N. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.05.010 · Cited by 610 · see citing works
Skin protection from solar ultraviolet radiation using natural compounds: a review
Verma, A., Zanoletti, A., Kareem, K. Y., Adelodun, B., Kumar, P., Ajibade, F. O., Silva, L. F. O., Phillips, A. J., Kartheeswaran, T., Bontempi, E., et al. (2024) · Environmental Chemistry Letters · doi:10.1007/s10311-023-01649-4 · Cited by 102 · see citing works
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Waqas, M., Akhtar, N., Rasul, A., Rashid, S., Mustafa, R., Khan, B., & Murtaza, G. (2014) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v13i9.4 · Cited by 17 · see citing works
- Authors
- Kim, S.-Y., Kim, S.-J., Lee, J.-Y., Kim, W.-G., Park, W.-S., Sim, Y.-C., & Lee, S.-J.
- Affiliations
- Amorepacific (South Korea) (KR)
- Venue
- Journal of the American College of Nutrition
- Publisher
- Informa UK Limited
- Published
- 2004-04
- Volume
- 23
- Issue
- 2
- Pages
- 157-162
- ISSN
- 0731-5724 (ISSN-L)
- 1541-1087
- OpenAlex
- W1991264226
- Cited by
- 100
- References
- 1
- Citations by year
- 2025: 2 · 2023: 6 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 9 · 2014: 9 · 2013: 11 · 2012: 8
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American College of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- soy isoflavones, dietary isoflavones, photoaging, UVB irradiation, skin aging, collagen deposition, epidermal thickness, dermal fibroblasts, metalloproteinases, MMP-1, collagen degradation, procollagen synthesis
- MeSH terms
- Administration, Oral, Animals, Cells, Cultured, Collagen, Female, Fibroblasts, Humans, Immunohistochemistry, Isoflavones, Mice, Hairless, Random Allocation, Skin, Ultraviolet Rays, Metalloproteases, Mice
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