The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Impact of the Discovery of Human Zinc Deficiency on Health
Abstract
The essentiality of zinc was recognized 46 years ago. Zinc deficiency resulting in growth retardation, hypogonadism, immune dysfunction and cognitive impairment affects nearly 2 billion subjects in the developing world. High phytate content of the cereal proteins consumed in the developing world, results in decreased availability of zinc for absorption. Zinc therapy has been very successful and life saving measure in patients with acrodermatitis enteropathica and Wilson's disease. Beneficial therapeutic responses of zinc supplementation have been ovserved in acute diarrhea in children, chronic hepatitis C, shigellosis, leprosy, leishmaniasis, and common cold. Zinc supplementation was effective in decreasing incidences of infection in elderly and patients with sickle cell disease. Zinc supplementation was effective in preventing blindness in 25% of the elderly with dry type of age related macular degeneration. Zinc supplementation in the elderly decreased oxidative stress and decreased generation of inflammatory cytokines. Zinc is an intracellular signaling molecule in monocytes, dendritic cells and macrophages and it plays an important role in cell-mediated immune functions and oxidative stress. Zinc is also an anti-inflammatory agent. These unique properties of zinc may have significant therapeutic benefits in several diseases in humans. In many diseases concurrent zinc deficiency may complicate the clinical features, affect adversely immunological status, increase oxidative stress and increase generation of inflammatory cytokines. Oxidative stress and chronic inflammation may play important causative roles in many chronic diseases, including atherosclerosis, several malignancies, neurological disorders, and auto-immune diseases. It is therefore, important that status of zinc is assessed and zinc deficiency corrected in these chronic diseases. A controlled clinical trial of zinc supplementation in these disorders in order to document the preventive and therapeutic effects of zinc is warranted.
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Cites
Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism, and geophagia
Prasad, A. S., Halsted, J. A., & Nadimi, M. (1961) · The American Journal of Medicine · doi:10.1016/0002-9343(61)90137-1 · Cited by 791
Self-citationPrasad, A. S., Beck, F. W., Bao, B., Fitzgerald, J. T., Snell, D. C., Steinberg, J. D., & Cardozo, L. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.837 · Cited by 516
Self-citationClinical, immunological, anti-inflammatory and antioxidant roles of zinc
Prasad, A. S. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.10.013 · Cited by 454
Self-citationZinc Supplementation in Young Children with Acute Diarrhea in India
Sazawal, S., Black, R. E., Bhan, M. K., Bhandari, N., Sinha, A., & Jalla, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331304 · Cited by 383
Serum thymulin in human zinc deficiency
Prasad, A. S., Meftah, S., Abdallah, J., Kaplan, J., Brewer, G. J., Bach, J. F., & Dardenne, M. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113717 · Cited by 335
Self-citation(2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.5.716 · Cited by 215
Prasad, A. S., Beck, F. W. J., Bao, B., Snell, D., & Fitzgerald, J. T. (2008) · The Journal of Infectious Diseases · doi:10.1086/528803 · Cited by 121
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Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355
Zinc: Dietary intake and impact of supplementation on immune function in elderly
Mocchegiani, E., Romeo, J., Malavolta, M., Costarelli, L., Giacconi, R., Diaz, L.-E., & Marcos, A. (2013) · AGE · doi:10.1007/s11357-011-9377-3 · Cited by 198
Infantile zinc deficiency: Association with autism spectrum disorders
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Wołonciej, M., Milewska, E., & Roszkowska-Jakimiec, W. (2016) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/17322693.1229074 · Cited by 171
Metadata
- Authors
- Prasad, A. S.
- Venue
- Journal of the American College of Nutrition
- Publisher
- Informa UK Limited
- Published
- 2009-06
- Volume
- 28
- Issue
- 3
- Pages
- 257-265
- ISSN
- 0731-5724 (ISSN-L)
- 1541-1087
- OpenAlex
- W2040741743
- Cited by
- 315
- References
- 8
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- closed
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