Trace elements as an activator of antioxidant enzymes

Wołonciej, Marta; Milewska, Elżbieta; Roszkowska-Jakimiec, Wiesława

doi:10.5604/17322693.1229074

Cited by 171Trace Elements in HealthSelenium in Biological SystemsAntioxidant Activity and Oxidative Stress

Trace elements as an activator of antioxidant enzymes

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Wołonciej, Marta, Milewska, Elżbieta, Roszkowska-Jakimiec, Wiesława·2016·Postępy Higieny i Medycyny Doświadczalnej

DOI 10.5604/17322693.1229074

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Abstract

Oxidative stress is a state of impaired balance between the formation of free radicals and antioxidant capacity of the body. It causes many defects of the body, e.g. lipid peroxidation, DNA and protein damage. In order to prevent the effects of oxidative stress, the organism has developed defence mechanisms. These mechanisms capture and inhibit the formation of free radicals and also chelate ion metals that catalyse free radical reactions. Trace elements are components of antioxidant enzymes involved in antioxidant mechanisms. Selenium, as a selenocysteine, is a component of the active site of glutathione peroxidase (GPx). The main function of GPx is neutralization of hydrogen peroxide (H2O2) and organic peroxide (LOOH). Furthermore, selenium is a structural part of a large group of selenoproteins that are necessary for proper functioning of the body. Manganese, copper and zinc are a part of the group of superoxide dismutase enzymes (MnSOD, Cu/ZnSOD), which catalyse the superoxide anion dismutation into hydrogen peroxide and oxygen. Formed hydrogen peroxide is decomposed into water and oxygen by catalase or glutathione peroxidase. An integral component of catalase (CAT) is iron ions. The concentration of these trace elements has a significant influence on the activity of antioxidant enzymes, and thus on defence against oxidative stress. Even a small change in the level of trace elements in the tissue causes a disturbance in their metabolism, leading to the occurrence of many diseases.

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Copper deficiency reduces the activity of the enzyme Cu/Zn-SOD and ceruloplasmin, as well as copper-independent enzymes, including catalase and glutathione peroxidase.
“Copper deficiency reduces the activity of the enzyme Cu/Zn-SOD and ceruloplasmin, as well as copper-independent enzymes, including catalase and glutathione peroxidase.”
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Authors: Wołonciej, M., Milewska, E., & Roszkowska-Jakimiec, W.
Affiliations: Medical University of Białystok (PL)
ORCID: Wołonciej, Marta
Milewska, Elżbieta
Roszkowska-Jakimiec, Wiesława
Venue: Postępy Higieny i Medycyny Doświadczalnej
Publisher: Walter de Gruyter GmbH
Published: 2016-12-31
Volume: 70
Issue: 0
Pages: 1483-1498
ISSN: 0032-5449 (ISSN-L)
1732-2693
DOI: 10.5604/17322693.1229074
OpenAlex: W2573113366
Cited by: 171
References: 88
Citations by year: 2026: 13 · 2025: 20 · 2024: 27 · 2023: 27 · 2022: 28 · 2021: 15 · 2020: 17 · 2019: 7 · 2018: 15 · 2017: 2
FWCI: 8.36
Type: journal article
Language: pl
Open access: diamond
doi.org
Locations: Postępy Higieny i Medycyny Doświadczalnej (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: trace elements, antioxidant enzymes, oxidative stress, selenium, glutathione peroxidase, selenoproteins, superoxide dismutase, catalase, manganese, copper, zinc, free radicals, lipid peroxidation, metal chelation
MeSH terms: Superoxide Dismutase 2, Catalase, Coenzymes, Copper, Enzyme Activation, Free Radicals, Glutathione Peroxidase, Manganese, Selenium, Superoxide Dismutase, Trace Elements, Zinc, Oxidative Stress

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Trace elements as an activator of antioxidant enzymes

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