Hypoxia: A Double-Edged Sword in Cancer Therapy

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717

Targeting hypoxia in cancer therapy

Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced: MDSC-mediated T cell activation

Noman, M. Z., Desantis, G., Janji, B., Hasmim, M., Karray, S., Dessen, P., Bronte, V., & Chouaib, S. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20131916 · Cited by 2,166

Role of oxygen radicals in DNA damage and cancer incidence

Valko, M., Izakovic, M., Mazur, M., Rhodes, C. J., & Telser, J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000049134.69131.89 · Cited by 1,820

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

Ostrand‐Rosenberg, S., & Sinha, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802740 · Cited by 1,777

The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

Brown, J. M., & Giaccia, A. J. (1998) · PubMed · Cited by 1,499

DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Reparability

Ward, J. F. (1988) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60611-x · Cited by 1,499

Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity

Curiel, T. J., Wei, S., Dong, H., Alvarez, X., Cheng, P., Mottram, P., Krzysiek, R., Knutson, K. L., Daniel, B., Zimmermann, M. C., et al. (2003) · Nature Medicine · doi:10.1038/nm863 · Cited by 1,314

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

McKeown, S. R. (2014) · The British Journal of Radiology · doi:10.1259/bjr.20130676 · Cited by 1,050

Exploring Hypertension: The Role of AT1 Receptors, Sartans, and Lipid Bilayers

Georgiou, N., Chontzopoulou, E., Routsi, E. A., Stavrakaki, I. G., Petsas, E., Zoupanou, N., Kakava, M. G., Tzeli, D., Mavromoustakos, T., & Kiriakidi, S. (2024) · ACS Omega · doi:10.1021/acsomega.4c06351 · Cited by 10

A Radiosensitivity Prediction Model Developed Based on Weighted Correlation Network Analysis of Hypoxia Genes for Lower-Grade Glioma

Du, Z., Liu, H., Bai, L., Yan, D., Li, H., Peng, S., Cao, J., Liu, S., & Tang, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.757686 · Cited by 7

Selecting the appropriate indirect viability assay for 3D paper-based cultures: a data-driven study

Sitte, Z. R., Larson, T. S., McIntosh, J. C., Sinanian, M., & Lockett, M. R. (2023) · The Analyst · doi:10.1039/d3an00283g · Cited by 8

Histone H3 activates caspase-1 and promotes proliferation and metastasis in hepatocellular carcinoma

Jing, M., Qiong, L., Wang, Z., Xiong, X., Fu, Y., & Yan, W. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.76580 · Cited by 7

Visualization of hypoxia in cancer cells from effusions in animals and cancer patients

Li, Y., Zhao, L., Huo, Y., Yang, X., Li, Y., Xu, H. Y., & Li, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1019360 · Cited by 7

Hypoxia Affects Mitochondrial Stress and Facilitates Tumor Metastasis of Colorectal Cancer Through Slug SUMOylation

Wang, J., Ding, S., Liu, X.-S., Yu, T., Wu, Z., & Li, Y. (2023) · Current Molecular Medicine · doi:10.2174/0115665240271525231112121008 · Cited by 7

Carbonic Anhydrase Inhibitor Acetazolamide Enhances CHOP Treatment Response and Stimulates Effector T-Cell Infiltration in A20/BalbC Murine B-Cell Lymphoma

Méhes, G., Matolay, O., Beke, L., Czenke, M., Pórszász, R., Mikó, E., Bai, P., Berényi, E. L., & Trencsényi, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145001 · Cited by 7

Oxygenating the way for enhanced chemophototherapy

Jiang, W., Delahunty, I. M., & Xie, J. (2018) · Theranostics · doi:10.7150/thno.27810 · Cited by 7

Hypoxia and programmed cell death-ligand 1 expression in the tumor microenvironment: a review of the effects of hypoxia-induced factor-1 on immunotherapy

Chamani, F. K., Etebari, A., Hajivalili, M., Mosaffa, N., & Jalali, S. A. (2024) · Molecular Biology Reports · doi:10.1007/s11033-023-08947-8 · Cited by 6

BE-43547A2 exerts hypoxia-selective inhibition on human pancreatic cancer cells through targeting eEF1A1 and disrupting its association with FoxO1

Liu, C., Liu, C., Liu, G., Wang, M., Jiao, Y., Sun, Y., Guo, H., Wang, L., Lu, Y., Chen, Y., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01461-y · Cited by 6

Identification of hypoxia-related prognostic signature for ovarian cancer based on Cox regression model

(2022) · European Journal of Gynaecological Oncology · doi:10.31083/j.ejgo4302031 · Cited by 6

The Effects of Dimethylsulfoxide and Oxygen on DNA Damage Induction and Repair Outcomes for Cells Irradiated by 62 MeV Proton and 3.31 MeV Helium Ions

Chan, C.-C., & Hsiao, Y.-Y. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11040286 · Cited by 6

Functional Roles and Mechanistic Insights of YEATS Domain Proteins in Digestive System Tumors

Chang, F., Yang, Y., Li, X., Dong, H., & Liu, K. (2025) · Digestive Diseases and Sciences · doi:10.1007/s10620-025-09117-5 · Cited by 5

The role and therapeutic value of NUSAP1 in human cancers

Xu, S., Nan, D., Liu, R., Liu, C., Hu, Y., Huang, L., Chen, X., Sheng, H., Lü, Y., & Zhang, H. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06746-2 · Cited by 5

BIRC7 is Beneficial for Melanoma Progression and Hypoxic Response

Xu, H., Liu, H., Li, Z., Xu, Q. L., Lin, N., & Li, X. (2022) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s370969 · Cited by 4

Whirlwind Acoustic Vortex‐Regulated Intelligent Microbots for Enhanced Uniform Drug Bioaccumulation to Boost Systemic Immunity Against Large Tumors

Ya, Z., Wu, H., Jia, W., Chu, H., Zhu, M., Li, Y., Zhang, L., Zong, Y., Guo, S., & Wan, M. (2025) · Small · doi:10.1002/smll.202503639 · Cited by 4

Prospective Long-Term Follow-Up of Pulmonary Diffusion Capacity Reduction Caused by Dose-Dense Chemotherapy in Patients with Breast Cancer

Landman, Y., Stemmer, S. M., Sulkes, A., Neiman, V., Granot, T., Hendler, D., Kramer, M. R., Gelmon, K. A., & Yerushalmi, R. (2019) · Journal of Oncology · doi:10.1155/2019/2584859 · Cited by 4

Oxidative Stress and Hypoxia in Cancer: Implications for Radiation Therapy

Roy, A., Tubin, S., Dwarakanath, B. S. R., & Gupta, S. (2022) · Springer eBooks · doi:10.1007/978-981-15-9411-3_136 · Cited by 3

Integrating Postradiotherapy MRI ‐Detected Lymph Node Necrosis and Pre‐ and Posttreatment Epstein–Barr Virus‐DNA for Risk Stratification in Nasopharyngeal Carcinoma

Cao, D., Li, S., Li, H., Liu, L., Wang, X., & Quan, T.-T. (2022) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28515 · Cited by 3

Exploring the underlying molecular mechanism of liver cancer cells under hypoxia based on RNA sequencing

Zhao, X., Liu, W., Liu, B., Zeng, Q., Cui, Z., Wang, Y., Cao, J., Gao, Q., Zhao, C., & Dou, J. (2022) · BMC Genomic Data · doi:10.1186/s12863-022-01055-9 · Cited by 3

A Hypoxia-Related Signature for Predicting Prognosis, Cellular Processes, Immune Microenvironment and Targeted Compounds in Lung Squamous Cell Carcinoma

Wu, G., Zhu, Z., Yang, Z., He, M., Ren, K., Dong, Y., & Xue, Q. (2022) · International Journal of General Medicine · doi:10.2147/ijgm.s344228 · Cited by 2

Single-cell sequencing revealed the recurrence causes of ETV6:RUNX1 fusion-positive B-ALL in children

Guan, G., Wang, X., Li, X., Wang, Q., Li, X., Sun, X., Liu, L., Lu, Y., Liu, B., Li, X., et al. (2025) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2025.102041 · Cited by 2

Genetic variability of HIF1A and response to treatment with cisplatin in combination with pemetrexed or gemcitabine in patients with malignant mesothelioma

Setina, M., Setina, E., Doljak, Z., Goričar, K., Dolžan, V., & Kovač, V. (2025) · Radiology and Oncology · doi:10.2478/raon-2025-0049 · Cited by 2

Spatiotemporally Ultrasound-Activatable Self-Amplifying Biomimetic Liposomes for Imaging-Guided Synergistic Cancer Sonodynamic Chemotherapy

He, Y., Zhao, H., Zheng, G., Sun, K., Deng, D., Wang, Y., Gong, T., Chen, J., Chen, X., Yang, H., et al. (2025) · Nano Letters · doi:10.1021/acs.nanolett.5c03350 · Cited by 2

The role of oxidative stress in the etiology of selected civilization diseases

Koczurkiewicz, P., Gąsiorkiewicz, B., Pękala, E., & Bojdo, P. (2021) · Farmacja Polska · doi:10.32383/farmpol/134797 · Cited by 2

The development and experimental validation of hypoxia-related long noncoding RNAs prognostic signature in predicting prognosis and immunotherapy of cutaneous melanoma

Wang, G., Sun, Y., & Xu, Q. (2023) · Aging · doi:10.18632/aging.205157 · Cited by 2

Normobaric hyperoxia re-sensitizes paclitaxel-resistant lung cancer cells

Im, J., Kwon, H. Y., Kim, I. K., Yeo, C. D., Kim, S. W., Lee, H., Kang, H. S., & Lee, S. H. (2022) · Molecular & Cellular Toxicology · doi:10.1007/s13273-022-00225-1 · Cited by 2

PO2‑based biodosimetry evaluation using an EPR technique acts as a sensitive index for chemotherapy

Li, Y., Xu, S., & Cai, M. (2018) · Oncology Letters · doi:10.3892/ol.2018.8911 · Cited by 2

Investigating the Benefit of Combined Androgen Modulation and Hypofractionation in Prostate Cancer

Zamagni, A., Zanoni, M., Cortesi, M., Arienti, C., Pignatta, S., Naldini, A., Sarnelli, A., Romeo, A., & Tesei, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228447 · Cited by 1

Bacteria-Based Roles in Solid Tumors: Potential for Prevention and Treatment

Huang, J., Zhang, A., Sun, J., Fu, Y., Li, W., & Wang, Y. (2025) · Pathogens · doi:10.3390/pathogens14090874 · Cited by 2

Unravelling the mystery of hypoxia-induced miRNAs in breast cancer: A molecular cross-talk driving tumour progression and therapy resistance

Sharma, N., Yadav, V., Sinha, S., Kumari, L., Sethi, A., Marcus, S., Singh, M., Kaur, S., Garg, N., Pathak, A., et al. (2026) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2026.101486 · Cited by 1

Hypoxic transcriptomes predict survival and tumor-infiltrating immune cell composition in cutaneous melanoma

Diaz, M. J., Quach, J. U., Song, J. J., Milanovic, S., Tran, J. T., Ladehoff, L. C., Batchu, S., Whitman, P., Kaffenberger, B. H., & Montanez-Wiscovich, M. E. (2024) · Melanoma Research · doi:10.1097/cmr.0000000000000938 · Cited by 1

Exploring the relationship between hypoxia in lung adenocarcinoma and tumor microenvironment immune cell infiltration

Gu, C., Guo, S., & Li, H. (2025) · Discover Oncology · doi:10.1007/s12672-025-02822-7 · Cited by 1

Hypoxic microenvironment promotes proliferation and invasion of non-small cell lung cancer A549 Cells through Wnt/β-catenin signaling pathway

Ma, R., He, X., Wang, H., Jia, W., & Zeng, X. (2018) · Biomedical Research - India · doi:10.4066/biomedicalresearch.29-17-2317 · Cited by 1

Radioresistencia en glioblastoma: papel de la hipoxia en la genotoxicidad inducida por radiaciones ionizantes

Forero, K. C., Langer, M. B., Paternina, A. F. M., Vega, C. M., Calvete, P. C. R., Guerra, A. M., Cruz-Cuevas, J. D., Suta, J. C., Martínez, M. A., Herrera, D. P., et al. (2018) · Ciencia e Investigación Medico Estudiantil Latinoamericana · doi:10.23961/cimel.v23i1.1066

Targeting CD155 on Myeloid Derived Suppressor Cells to Prevent Postoperative Immunosuppression in Cancer Patients

Martel, A. B. (2020) · uO Research (University of Ottawa) · doi:10.20381/ruor-25375

Dual Function Molecules and Processes in Cell Fate Decision: A Preface to the Special Issue

Emanuele, S., & Giuliano, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249601

Oxidative Stress and Hypoxia in Cancer: Implications for Radiation Therapy

Roy, A., Tubin, S., Dwarakanath, B. S. R., & Gupta, S. (2021) · Springer eBooks · doi:10.1007/978-981-15-4501-6_136-1

A simple formula based on postprandial plasma glucose prediction using 5,640 meals data via GH-Method: math-physical medicine (No. 301)

(2020) · Journal of Clinical & Experimental Immunology · doi:10.33140/jcei.05.05.04

Devices for Sample Preparation

Thurow, K., & Junginger, S. (2022) · doi:10.1002/9783527829446.ch7

Health Effects of Smartphones in 14-19 Age Young People

Yarbağ, A., & Yazar, H. (2023) · Online Türk Sağlık Bilimleri Dergisi · doi:10.26453/otjhs.1325700

Additional file 1 of A role for ceruloplasmin in the control of human glioblastoma cell responses to radiation

Roy, C., Avril, S., Legendre, C., Lelièvre, B., Vellenriter, H., Boni, S., Cayon, J., Guillet, C., Guilloux, Y., Chérel, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20423903

Additional file 1 of Exploring the underlying molecular mechanism of liver cancer cells under hypoxia based on RNA sequencing

Zhao, X., Liu, W., Liu, B., Zeng, Q., Cui, Z., Wang, Y., Cao, J., 高庆军, Zhao, C., & Dou, J. (2022) · Figshare · doi:10.6084/m9.figshare.19801437

Measuring the oncological value of exercise and statins (MOVES): Changing the tumour microenvironment with exercise and statins — an exploratory pilot trialPreprint

Murtola, T. J., Hakulinen, A., Penttinen, H., Jukkola‐Vuorinen, A., Raittinen, P. V. H., Jussila, I., Ilmonen, P., Ojala, H., Pietilä, I., Synnöve, S., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-8501963/v1

A computational method to estimate the relative biological effectiveness and tumor control probability for low-LET proton irradiations

Chan, C.-C., Hsueh, K.-L., Lai, C.-Y., & Hsiao, Y.-Y. (2026) · PLoS ONE · doi:10.1371/journal.pone.0341352

Insights Into Natural Photosensitizer‐Based Nanotherapeutics in Photodynamic Therapy of Cancer

Parua, P., Ghosh, S., Parua, P., Dey, C., Jana, K., Debnath, B., Halder, J., Sahoo, R. K., Rai, V. K., Dash, P., et al. (2026) · ChemistrySelect · doi:10.1002/slct.74070

Target for tumor hypoxia

Jian, D. (2004) · Zhongguo aizheng zazhi

Tumor Hypoxia and Radioresistance

Morović, S. (2024) · Radiološki vjesnik · doi:10.55378/rv.48.2.6 · Cited by 3

A Review of the Role of Hypoxia in Radioresistance in Cancer Therapy

Bouleftour, W., Rowinski, E., Louati, S., Sotton, S., Wozny, A., Moreno-Acosta, P., Méry, B., Rodriguez‐Lafrasse, C., & Magné, N. (2021) · Medical Science Monitor · doi:10.12659/msm.934116 · Cited by 130

An Enhanced Scrutiny of Mechanistic and Translational Approaches to Extinguish Cancer Hypoxia

Radhakrishnan, A., Shanmukhan, N. K., & Linda Christabel, S. (2024) · Pharmaceutical Nanotechnology · doi:10.2174/0122117385328105241216042016

Tumor Hypoxia

Nordsmark, M., Busk, M., Petersen, J. B. B., Alsner, J., Overgaard, J., & Horsman, M. R. (2014) · Elsevier eBooks · doi:10.1016/b978-0-444-53632-7.00903-5