An Improved Method for the Production of Ac-225/Bi-213 from Th-229 for Targeted Alpha Therapy.
Abstract
This work describes an improved method for radium/actinium separation as part of a process for the production of Ac‐225 from a Th‐229 source for targeted alpha therapy of cancer. The separation method is based on the use of a newly developed extraction chromatographic resin containing the diglycolamide (DGA) class of molecules. The weight distribution ratios of Ac(III) on the extraction chromatographic resins N,N,N′N′ tetraoctyldiglycolamide (TODGA) and N,N,N′N′ tetrakis‐2‐ethylhexyldiglycolamide (TEHDGA) (both Eichrom Inc.) were determined at varying nitric and hydrochloric acid concentrations by batch experiments to optimize conditions for the separation of Ac(III) from Ra(II). Consequently, a robust and rapid procedure based on the use of TEHDGA resin was developed yielding a carrier‐free, clinical‐grade Ac‐225 with an overall yield exceeding 98%.
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The Joint Research Centre in Karlsruhe, Germany, has produced approximately 13 GBq 225Ac annually since the 1990s.
“The Directorate for Nuclear Safety and Security of the Joint Research Centre (JRC) of the European Commission in Karlsruhe, Germany, the first laboratory to prepare 225Ac/213Bi, has produced approximately 13 GBq 225Ac annually since the 1990s for their center and a wide network of clinical collaborators (89, 90).”
From Alpha-peptide receptor radionuclide therapy using actinium-225 labeled somatostatin receptor agonists and antagonists (2022) · cites this paper as [90]
Cites
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Production of Ac-225 from Th-229 for Targeted α Therapy
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Self-citationAggregation Properties of N , N , N ′, N ′‐Tetraoctyl‐3‐oxapentanediamide (TODGA) in n ‐Dodecane
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Self-citationIntralesional targeted alpha therapy for metastatic melanoma
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Self-citationTargeted Killing of Virally Infected Cells by Radiolabeled Antibodies to Viral Proteins
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Kratochwil, C., Bruchertseifer, F., Rathke, H., Bronzel, M., Apostolidis, C., Weichert, W., Haberkorn, U., Giesel, F. L., & Morgenstern, A. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.191395 · Cited by 505 · see citing works
Self-citationSupply and clinical application of Actinium-225 and Bismuth-213.
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Shi, M., Jakobsson, V., Greifenstein, L., Khong, P.-L., Chen, X., Baum, R. P., & Zhang, J. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1034315 · Cited by 68 · see citing works
- Authors
- Zielinska, B., Apostolidis, C., Bruchertseifer, F., & Morgenstern, A.
- Affiliations
- European Commission (BE)
- Corresponding author
- Morgenstern, A.
- Venue
- Solvent Extraction and Ion Exchange
- Publisher
- Informa UK Limited
- Published
- 2007-04
- Volume
- 25
- Issue
- 3
- Pages
- 339-349
- ISSN
- 0736-6299 (ISSN-L)
- 1532-2262
- OpenAlex
- W2035535455
- Cited by
- 100
- References
- 10
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 7 · 2022: 5 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 8 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 7 · 2012: 5
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Solvent Extraction and Ion Exchange (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Physical Sciences › Chemistry › Inorganic Chemistry › Radioactive element chemistry and processing
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Chemical Reactions and Isotopes
- Keywords
- actinium-225, bismuth-213, thorium-229, radium-224, targeted alpha therapy, diglycolamide extractants, extraction chromatography, carrier-free radionuclides, radioisotope production, cancer therapy
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