Supply and clinical application of Actinium-225 and Bismuth-213.
Open accessAbstract
The recent development of 225Ac-PSMA617 for therapy of prostate cancer has strikingly demonstrated the clinical potential of targeted alpha therapy. Further promising applications of the alpha emitters 225Actinium and its daughter nuclide 213Bismuth include the therapy of brain tumors, bladder cancer, neuroendocrine tumors, and leukemia. This paper will provide a brief overview on the current status of the clinical development of compounds labelled with 225Ac or 213Bi and describe the various production routes that are in place or are under development to meet the increasing demand for these radionuclides.
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Worldwide, only three sources of 229Th are available.
“Worldwide, only three sources of 229Th are available (81).”
From Alpha-peptide receptor radionuclide therapy using actinium-225 labeled somatostatin receptor agonists and antagonists (2022) · cites this paper as [81]
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- Authors
- Morgenstern, A., Apostolidis, C., & Bruchertseifer, F.
- Affiliations
- European Commission (BE)
- Corresponding author
- Morgenstern, Alfred
- Venue
- Seminars in Nuclear Medicine
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 50
- Issue
- 2
- Pages
- 119-123
- ISSN
- 0001-2998 (ISSN-L)
- PMC
- PMC7082773
- OpenAlex
- W3007334567
- Cited by
- 141
- References
- 45
- Citations by year
- 2026: 16 · 2025: 31 · 2024: 23 · 2023: 19 · 2022: 15 · 2021: 29 · 2020: 8
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Seminars in Nuclear Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Joint Research Centre (European Commission) (submittedVersion)
- Funders
- Joint Research Centre
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Chemical Reactions and Isotopes
- Physical Sciences › Physics and Astronomy › Radiation › Radioactive Decay and Measurement Techniques
- Keywords
- actinium-225, bismuth-213, targeted alpha therapy, prostate cancer, radioisotope production, radionuclide supply, alpha-emitting radionuclides, neuroendocrine tumors, brain tumors, leukemia, bladder cancer
- MeSH terms
- Actinium, Bismuth, Humans, Isotope Labeling, Male, Prostatic Neoplasms, Radioisotopes
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