The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Drug-activated nuclear receptors CAR and PXR
Open accessAbstract
The metabolism and elimination of drugs is mainly mediated by cytochrome P450 (CYP) enzymes, aided by conjugative enzymes and transport proteins. An integral aspect of this elimination process is the induction of drug metabolism through activation of gene expression of metabolic and transport proteins. There is compelling evidence that induction is regulated by drug-activated nuclear receptors constitutive androstane receptor (CAR) and pregnane X receptor (PXR). This review outlines the basic properties of CAR and PXR, their ligands and target genes, and the mechanisms of the induction process. The implications of nuclear receptor-mediated induction for drug research are also discussed.
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Cites
Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C. M., Tontonoz, P., Kliewer, S., Willson, T. M., & Edwards, P. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109326200 · Cited by 916
Cited by
Martignoni, M., Groothuis, G. M. M., & de Kanter, R. (2006) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2.6.875 · Cited by 1,478
Molecular Mechanisms of Vitamin D Action
Haussler, M. R., Whitfield, G. K., Kaneko, I., Haussler, C. A., Hsieh, D., Hsieh, J.-C., & Jurutka, P. W. (2013) · Calcified Tissue International · doi:10.1007/s00223-012-9619-0 · Cited by 759
Induction of Drug Metabolism: The Role of Nuclear Receptors
Handschin, C., & Meyer, U. A. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.2 · Cited by 470
Huang, W., Zhang, J., Washington, M., Liu, J., Parant, J. M., Lozano, G., & Moore, D. D. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0520 · Cited by 284
Zhang, J., Huang, W., Qatanani, M., Evans, R. M., & Moore, D. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409041200 · Cited by 246
Metadata
- Authors
- Honkakoski, P., Sueyoshi, T., & Negishi, M.
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 35
- Issue
- 3
- Pages
- 172-182
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2040567225
- Cited by
- 180
- References
- 1
- FWCI
- 13.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Honkakoski, P., Sueyoshi, T., & Negishi, M. (2003). Drug-activated nuclear receptors CAR and PXR. Annals of Medicine. https://doi.org/10.1080/07853890310008224
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
