Apparent treatment-resistant hypertension – patient–physician relationship and ethical issues
Open accessAbstract
BACKGROUND: Poor drug adherence is a major cause of apparent treatment-resistant hypertension. As a consequence, several methods have been developed and attempted implemented in clinical practice to reveal non-adherence and to monitor drug adherence. There are, however, several hitherto unresolved ethical aspects regarding potential methods for drug monitoring in these patients. RESULTS: The most striking challenge is the balance between patient autonomy and the physician's desire for the patient to adhere to the prescribed therapy. Also, methods for monitoring must only be implemented in the treatment of well-informed and consenting patients. Major resources are used on non-adherent patients; how long the physician should encourage continuation of treatment is an important question. CONCLUSIONS: We believe that physicians should reflect and discuss these potential challenges, and that patient education, information and a solid patient-physician relationship are essential for achieving drug adherence. Methods for monitoring adherence represent, however, a useful and often necessary supplement.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A negative attitude towards medication is also a problem in the treatment of chronic physical diseases such as diabetes and high blood pressure.
“A negative attitude towards medication is not only a psychiatric phenomenon but also a problem in the treatment of chronic physical diseases such as diabetes and high blood pressure [35, 36].”
From Patients’ perception of coercion with respect to antipsychotic treatment of psychotic disorders and its predictors (2021) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.189141 · Cited by 1,404 · see citing works
Strategy of prevention: lessons from cardiovascular disease.
Rose, G. (1981) · BMJ · doi:10.1136/bmj.282.6279.1847 · Cited by 1,302 · see citing works
Interventions to Enhance Patient Adherence to Medication Prescriptions: Scientific Review
McDonald, H. P., Garg, A. X., & Haynes, R. B. (2002) · JAMA · doi:10.1001/jama.288.22.2868 · Cited by 1,176 · see citing works
Parati, G., Stergiou, G. S., Asmar, R., Bilo, G., de Leeuw, P., Imai, Y., Kario, K., Lurbe, E., Manolis, A., Mengden, T., et al. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e328308da66 · Cited by 837 · see citing works
Geography And The Debate Over Medicare Reform
Wennberg, J. E., Fisher, E. S., & Skinner, J. (2002) · Health Affairs · doi:10.1377/hlthaff.w2.96 · Cited by 593 · see citing works
Risk communication in practice: the contribution of decision aids
O'Connor, A. M. C., Légaré, F., & Stacey, D. (2003) · BMJ · doi:10.1136/bmj.327.7417.736 · Cited by 383 · see citing works
Burnier, M., Schneider, M. P., Chioléro, A., Stubi, C.-L. F., & Brunner, H. R. (2001) · Journal of Hypertension · doi:10.1097/00004872-200102000-00022 · Cited by 262 · see citing works
Cost-Effectiveness of Hypertension Therapy According to 2014 Guidelines
Moran, A. E., Odden, M. C., Thanataveerat, A., Tzong, K. Y., Rasmussen, P. W., Guzman, D., Williams, L. W., Bibbins-Domingo, K. B., Coxson, P. G., & Goldman, L. (2015) · New England Journal of Medicine · doi:10.1056/nejmsa1406751 · Cited by 237 · see citing works
Measuring, Analyzing, and Managing Drug Adherence in Resistant Hypertension
Burnier, M., Wuerzner, G., Struijker-Boudier, H., & Urquhart, J. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.00687 · Cited by 229 · see citing works
Elmula, F. E. M. F., Hoffmann, P., Larstorp, A. C. K., Fossum, E., Brekke, M., Kjeldsen, S. E., Gjønnæss, E., Hjørnholm, U., Kjær, V. N., Rostrup, M., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03246 · Cited by 209 · see citing works
Self-citationBerra, E., Azizi, M., Capron, A., Høieggen, A., Rabbia, F., Kjeldsen, S. E., Staessen, J. A., Wallemacq, P., & Persu, A. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07464 · Cited by 195 · see citing works
Self-citationTherapeutic Drug Monitoring Facilitates Blood Pressure Control in Resistant Hypertension
Brinker, S. K., Pandey, A., Ayers, C., Price, A. L., Raheja, P., Arbique, D., Das, S. R., Halm, E., Kaplan, N., & Vongpatanasin, W. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.10.067 · Cited by 181 · see citing works
Long-Term Prognostic Value of White Coat Hypertension
Mancia, G., Bombelli, M., Brambilla, G., Facchetti, R., Sega, R., Toso, E., & Grassi, G. M. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00690 · Cited by 152 · see citing works
Zisaki, A., Mišković, L., & Hatzimanikatis, V. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666141024151119 · Cited by 117 · see citing works
Weitzman, D., Chodick, G., Shalev, V., Grossman, C., & Grossman, E. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03718 · Cited by 113 · see citing works
Science, Ethics, and the Making of Clinical Decisions
Forrow, L. (1988) · JAMA · doi:10.1001/jama.1988.03720210051029 · Cited by 83 · see citing works
Adherence to medication and drug monitoring in apparent treatment-resistant hypertension
Eskås, P. A., Heimark, S., Mariampillai, J. E., Larstorp, A. C. K., Elmula, F. E. M. F., & Høieggen, A. (2016) · Blood Pressure · doi:10.3109/08037051.2015.1121706 · Cited by 70 · see citing works
Self-citationPersistence to antihypertensive drug treatment in Swedish primary healthcare
Qvarnström, M., Kahan, T., Kieler, H., Brandt, L., Hasselström, J., Boström, K. B., Manhem, K., Hjerpe, P., & Wettermark, B. (2013) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-013-1555-z · Cited by 64 · see citing works
Eligibility for Renal Denervation
Persu, A., Jin, Y., Baelen, M., Vink, E. E., Verloop, W. L., Schmidt, B. M. W., Blicher, M. K., Severino, F., Wuerzner, G., Taylor, A. H. M., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03194 · Cited by 63 · see citing works
Self-citationPotential cost-effectiveness of therapeutic drug monitoring in patients with resistant hypertension
Chung, O., Vongpatanasin, W., Bonaventura, K., Lotan, Y., Sohns, C., Haverkamp, W., & Dorenkamp, M. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000346 · Cited by 46 · see citing works
Mascarenhas, O. A. J., Cardozo, L. J., Afonso, N., Siddique, M. S., Steinberg, J. D., Lepczyk, M., & Aranha, A. N. F. (2006) · Clinical Interventions in Aging · doi:10.2147/ciia.2006.1.2.175 · Cited by 44 · see citing works
Ethical issues of compliance/adherence in the treatment of hypertension
Bernardini, J. Y. (2004) · Advances in Chronic Kidney Disease · doi:10.1053/j.arrt.2004.01.003 · Cited by 18 · see citing works
Tertiary work-up of apparent treatment-resistant hypertension
Heimark, S., Eskås, P. A., Mariampillai, J. E., Larstorp, A. C. K., Høieggen, A., & Elmula, F. E. M. F. (2016) · Blood Pressure · doi:10.3109/08037051.2016.1172865 · Cited by 18 · see citing works
Self-citationCost-Effectiveness of Hypertension Therapy According to 2014 Guidelines
(2015) · New England Journal of Medicine · doi:10.1056/nejmx150016 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hirsch, S., Thilo, N., Steinert, T., & Flammer, E. (2021) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-021-02083-z · Cited by 9 · see citing works
- Authors
- Mariampillai, J. E., Eskås, P. A., Heimark, S., Larstorp, A. C. K., Fadl Elmula, F. E. M., Høieggen, A., & Nortvedt, P.
- Affiliations
- University of Oslo (NO)
- Oslo University Hospital (NO)
- Faculty of Medicine, University of Oslo, Oslo, Norway;
- Corresponding author
- Høieggen, Aud
- Venue
- Blood Pressure
- Publisher
- Informa UK Limited
- Published
- 2017-01-12
- Volume
- 26
- Issue
- 3
- Pages
- 133-138
- ISSN
- 0803-7051 (ISSN-L)
- 1651-1999
- OpenAlex
- W2576518342
- Cited by
- 16
- References
- 24
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 2
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood Pressure (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics and bioethics in healthcare
- Keywords
- treatment-resistant hypertension, medication adherence, medication non-adherence, physician-patient relationship, medical ethics, patient autonomy, informed consent, adherence monitoring, patient education
- MeSH terms
- Antihypertensive Agents, Blood Pressure, Drug Resistance, Humans, Hypertension, Informed Consent, Patient Compliance, Patient Participation, Patients, Physician-Patient Relations, Physicians, Drug Monitoring, Patient Medication Knowledge
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
