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Cited by 32Schizophrenia research and treatmentMental Health and PsychiatryPsychopathy, Forensic Psychiatry, Sexual Offending

Sex differences in schizophrenia: A review

Sami Räsänen, Antti Pakaslahti, Erkka Syvälahti, Peter Jones·2000·Nordic Journal of Psychiatry
DOI 10.1080/080394800427564
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Abstract

During the past decade schizophrenia research has emphasized the importance of sex differences. Most studies have found that lifetime risk of schizophrenia has been equally common in both sexes. Men develop schizophrenia 3-4 years earlier than women, regardless of culture, but late-onset schizophrenia has been found to be commoner in women. Women more often have a favorable course of schizophrenia than men: they experience fewer and shorter hospitalizations, survive longer in the community, and also have better social functioning. Men more often have chronic and more severe forms of schizophrenia, they have negative symptoms more often, and their doses of neuroleptic medication are higher. Men with schizophrenia tend to have more central nervous system abnormalities than women. In the future it is important to study factors that have been observed in sex differences, heredity, and brain physiology as they relate to schizophrenia. Sex differences as they relate to treatment programs are important both from a scientific perspective and from a practical point of view.

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Crossref · 10.1080/080394800427564

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  • Common variant genetic liability to schizophrenia is essentially identical in males and females despite reported sex differences in age at onset, symptoms, course, and outcome.

    “These and other analyses (Supplementary Note) show that common variant genetic liability to schizophrenia is essentially identical in males and females despite reported sex differences in age at onset, symptom profile, course, and outcome12.”

    From Mapping genomic loci implicates genes and synaptic biology in schizophrenia (2022) · cites this paper as [12]

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Authors
Sami Räsänen, A. P.
Affiliations
Department of Psychiatry, University of Oulu, Peltolantie 5, FIN-90210 Oulu, Finland
Venue
Nordic Journal of Psychiatry
Publisher
Informa UK Limited
Published
2000-01
Volume
54
Issue
1
Pages
37-45
ISSN
  • 0029-1455 (ISSN-L)
  • 0803-9488
  • 1502-4725
DOI
10.1080/080394800427564
OpenAlex
W2170172378
Cited by
32
References
126
Citations by year
2026: 3 · 2023: 1 · 2022: 4 · 2021: 2 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
1.41
Type
journal article
Language
en
Open access
closed
Locations
Nordic Journal of Psychiatry (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords
schizophrenia, sex differences, age of onset, late-onset schizophrenia, clinical course, hospitalization, social functioning, negative symptoms, antipsychotic drugs, brain abnormalities, heredity (biology), brain physiology, treatment programs

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