The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
G-CSF: A key regulator of neutrophil production, but that's not all!
Abstract
G-CSF is a major extracellular regulator of haemopoiesis and the innate immune system. Named for its relatively specific stimulation of the growth of neutrophil progenitor cells in vitro in semi-solid cultures (Burgess and Metcalf 1980, Nicola et al. 1983), G-CSF influences the survival, proliferation and differentiation of all cells in the neutrophil lineage, from haemopoietic stem cell through to mature neutrophil. Further, G-CSF influences the function of mature neutrophils. These actions underpin its rapid uptake into clinical medicine as a drug that increases the production of neutrophils in patients with chemotherapy-induced neutropenia. Ongoing research has uncovered initially unsuspected polyfunctionality for G-CSF. G-CSF is well recognised as a potent mobiliser of haemopoietic stem cells from the bone marrow into the blood, and now is being increasingly accepted as a regulator of immune responses. These two "new" actions of G-CSF first came to light through observations made during clinical trials of G-CSF. Subsequent investigations into the cellular and molecular basis for this polyfunctionality have generated exciting new knowledge about the biology of G-CSF. This review emphasises recent advances in knowledge about G-CSF signalling, mechanisms of G-CSF-induced stem cell mobilisation, and how G-CSF influences T-cell function and dendritic cell activation. An attempt is made to link the current issues about the biology of G-CSF with its clinical uses, both present a…
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“However, we observed lower levels of GCSF, which not only is a key regulator of neutrophil production [60] but also plays an essential role in neutrophil trafficking [61].”
From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [60]
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Cites
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“More recently, IL-17 has been implicated as a major upstream extracellular regulator of G-CSF production by tissues, particularly the bone marrow stroma (Fossiez et al. 1996).”
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Hamilton, J. A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2356 · Cited by 1,305
Modulators of microglial activation and polarization after intracerebral haemorrhage
Lan, X., Han, X., Li, Q., Yang, Q.-W., & Wang, J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.69 · Cited by 915
Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis
Nagareddy, P. R., Murphy, A. J., Stirzaker, R. A., Hu, Y., Yu, S., Miller, R. G., Ramkhelawon, B., Distel, E., Westerterp, M., Huang, L., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.001 · Cited by 599
The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis
Liang, W. P., & Ferrara, N. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0313 · Cited by 353
Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells
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Metadata
- Authors
- Roberts, A. W.
- Affiliations
- Walter and Eliza Hall Institute of Medical Research (AU)
- Corresponding author
- Roberts, Andrew W.
- ORCID
- Roberts, Andrew W.
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 2005-03
- Volume
- 23
- Issue
- 1
- Pages
- 33-41
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W1981127449
- Cited by
- 335
- References
- 87
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 14 · 2023: 25 · 2022: 35 · 2021: 27 · 2020: 21 · 2019: 17 · 2018: 16 · 2017: 22 · 2016: 17 · 2015: 17 · 2014: 20 · 2013: 20 · 2012: 18
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Growth Factors (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- Cancer Council Victoria
- National Medical Research Council
- National Cancer Institute (CA22556)
- Topics
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- granulocyte colony-stimulating factor, neutrophil production, hematopoiesis, T cell function, dendritic cell activation, innate immunity, chemotherapy-induced neutropenia, G-CSF therapy
- MeSH terms
- Animals, Dendritic Cells, Forecasting, Humans, Models, Biological, Neutropenia, Neutrophils, T-Lymphocytes, Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Mobilization
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