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G-CSF: A key regulator of neutrophil production, but that's not all!
Abstract
G-CSF is a major extracellular regulator of haemopoiesis and the innate immune system. Named for its relatively specific stimulation of the growth of neutrophil progenitor cells in vitro in semi-solid cultures (Burgess and Metcalf 1980, Nicola et al. 1983), G-CSF influences the survival, proliferation and differentiation of all cells in the neutrophil lineage, from haemopoietic stem cell through to mature neutrophil. Further, G-CSF influences the function of mature neutrophils. These actions underpin its rapid uptake into clinical medicine as a drug that increases the production of neutrophils in patients with chemotherapy-induced neutropenia. Ongoing research has uncovered initially unsuspected polyfunctionality for G-CSF. G-CSF is well recognised as a potent mobiliser of haemopoietic stem cells from the bone marrow into the blood, and now is being increasingly accepted as a regulator of immune responses. These two "new" actions of G-CSF first came to light through observations made during clinical trials of G-CSF. Subsequent investigations into the cellular and molecular basis for this polyfunctionality have generated exciting new knowledge about the biology of G-CSF. This review emphasises recent advances in knowledge about G-CSF signalling, mechanisms of G-CSF-induced stem cell mobilisation, and how G-CSF influences T-cell function and dendritic cell activation. An attempt is made to link the current issues about the biology of G-CSF with its clinical uses, both present a…
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“However, we observed lower levels of GCSF, which not only is a key regulator of neutrophil production [60] but also plays an essential role in neutrophil trafficking [61].”
From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [60]
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“More recently, IL-17 has been implicated as a major upstream extracellular regulator of G-CSF production by tissues, particularly the bone marrow stroma (Fossiez et al. 1996).”
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Metadata
- Authors
- Roberts, A. W.
- Affiliations
- Walter and Eliza Hall Institute of Medical Research (AU)
- Corresponding author
- Roberts, Andrew W.
- ORCID
- Roberts, Andrew W.
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 2005-03
- Volume
- 23
- Issue
- 1
- Pages
- 33-41
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W1981127449
- Cited by
- 335
- References
- 87
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 14 · 2023: 25 · 2022: 35 · 2021: 27 · 2020: 21 · 2019: 17 · 2018: 16 · 2017: 22 · 2016: 17 · 2015: 17 · 2014: 20 · 2013: 20 · 2012: 18
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Growth Factors (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- Cancer Council Victoria
- National Medical Research Council
- National Cancer Institute (CA22556)
- Topics
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- granulocyte colony-stimulating factor, neutrophil production, hematopoiesis, T cell function, dendritic cell activation, innate immunity, chemotherapy-induced neutropenia, G-CSF therapy
- MeSH terms
- Animals, Dendritic Cells, Forecasting, Humans, Models, Biological, Neutropenia, Neutrophils, T-Lymphocytes, Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Mobilization
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