The DOI matches its Crossref record; 194 of the 194 references it cites were found in a registry or an index.
Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
Abstract
Current understanding of the mechanisms by which cell growth is regulated lags significantly behind our knowledge of the complex processes controlling cell cycle progression. Recent studies suggest that the mammalian target of rapamycin (mTOR) pathway is a key regulator of cell growth via the regulation of protein synthesis. The key mTOR effectors of cell growth are eukaryotic initiation factor 4E-binding protein 1 (4EBP-1) and the ribosomal protein S6 kinase (S6K). Here we will review the current models for mTOR dependent regulation of ribosome function and biogenesis as well as its role in coordinating growth factor and nutrient signaling to facilitate homeostasis of cell growth and proliferation. We will place particular emphasis on the role of S6K1 signaling and will highlight the points of cross talk with other key growth control pathways. Finally, we will discuss the impact of S6K signaling and the consequent feedback regulation of the PI3K/Akt pathway on disease processes including cancer.
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“Activation of p70S6K is mediated by sequential phosphorylation on multiple sites by mTOR and PDK1, which is counteracted by PP2A/B56γ (Hahn et al., 2010; Jastrzebski et al., 2007).”
From PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer (2019) · cites this paper as Jastrzebski et al., 2007
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Cites
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216
Upstream and downstream of mTOR
Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083
Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,072
The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1
Hanks, S. K., & Hunter, T. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.8.7768349 · Cited by 2,828
Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665
Hanks, S. K., & Hunter, T. R. (1995) · PubMed · Cited by 2,518
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,365
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A., Hall, A., & Hall, M. N. (2004) · Nature Cell Biology · doi:10.1038/ncb1183 · Cited by 2,097
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Pérez‐Tenorio, G. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Edgett, B. A. (2012) · QSpace (Queen's University Library)
Georgievich, R. V., & Константинович, П. В. (2013)
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Zhang, H. (2015) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1939
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Shortt, J., Newbold, A., & Johnstone, R. W. (2010) · ANZ nuclear medicine
Singh, S. (2011) · Spiral (Imperial College London) · doi:10.25560/9605
Wang, R. (2014) · CU Scholar (University of Colorado Boulder)
Clapp, E. L. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique)
Kawata, K., Yugi, K., Hatano, A., Fujii, M., Tomizawa, Y., Kokaji, T., Sano, T., Tanaka, K. Y., Uda, S., Kubota, H., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/187088
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Zamora, A. C. P. (2015) · Griffith Research Online · doi:10.25904/1912/2151
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Pereyra, L. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7666
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Jungers, C. F., Elliff, J. M., Masson‐Meyers, D. S., Phiel, C. J., & Origanti, S. S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/476978
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Yan, Y., Zhu, X., He, F., Xiong, J., Tian, Y., Shi, W., Li, B., Liu, Z., Gu, N.-B., Jia, X.-T., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-710287/v1
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Martin, Z. (2021) · doi:10.32920/ryerson.14649699.v1 · Cited by 1
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Chang, L., Xue, Y., Zhu, X., Tian, Y., Liu, Z., Gu, N.-B., Jiang, Y. W., Ma, Y., Yong, F. Y., Jing, Y.-Y., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-1021026/v1
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Pavan, I. C. B., Silva, F. R., Morelli, A. P., & Simabuco, F. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101816
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Vasileva, A. N., Aleshina, O. A., Вениаминовна, Б. Б., & Sudarikov, A. B. (2022) · Oncohematology · doi:10.17650/1818-8346-2022-17-4-166-176
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Conte, M. L., Lucchino, V., Scalise, S., Zannino, C., Murfuni, M. S., Cicconetti, C., Scaramuzzino, L., Matassa, D. S., Procopio, A., Cuda, G., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.08.556837
Zhu, J., Han, L., Liu, R., Zhang, Z., Huang, Q., Fang, X., Yang, K., Huang, G., Zheng, Z., Yawalkar, N., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102589
Lee, N., Hwang, Y., Na, H. G., & Cho, D. (2024) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-024-00652-0
Abrisqueta, M. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Zhu, J., Han, L., Liu, R., Zhang, Z., Huang, Q., Fang, X., Yang, K., Huang, G., Zheng, Z., Yawalkar, N., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102577
Zhu, J., Han, L., Liu, R., Zhang, Z., Huang, Q., Fang, X., Yang, K., Huang, G., Zheng, Z., Yawalkar, N., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102586
Zhu, J., Han, L., Liu, R., Zhang, Z., Huang, Q., Fang, X., Yang, K., Huang, G., Zheng, Z., Yawalkar, N., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102595
Zhu, J., Han, L., Liu, R., Zhang, Z., Huang, Q., Fang, X., Yang, K., Huang, G., Zheng, Z., Yawalkar, N., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102583
Zhidkov, M. E., Popov, A. M., Soldatkina, O. A., Tryapkin, O. A., & Kharchenko, L. N. (2025) · Marine Drugs · doi:10.3390/md24010018
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Ndiaye, P. D. (2017) · theses.fr (ABES) · doi:10.70675/fa7c4865z5a22z4ef6z828cz73fb034ba31d
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Gillot, S. (2018) · theses.fr (ABES) · doi:10.70675/3971b589zc4c7z48bez8f2cz7946f0d4435d
BindingDB (2024) · UC San Diego · doi:10.7270/q20g3qc6
Jones, T. W. A. (2014) · Northumbria Research Link (Northumbria University)
The control of ribosomal RNA synthesis in mammalian cells
Zhang, Z. (2013) · ePrints Soton (University of Southampton)
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Furic, L., Livingstone, M., Topisirović, I., & Sonenberg, N. (2011) · Energy balance and cancer · doi:10.1007/978-1-4419-9911-5_8
Metadata
- Authors
- Jastrzebski, K., Hannan, K. M., Tchoubrieva, E. B., Hannan, R. D., & Pearson, R. B.
- Affiliations
- The University of Melbourne (AU)
- Peter MacCallum Cancer Centre (AU)
- Corresponding author
- Pearson, Richard B.
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 2007-01
- Volume
- 25
- Issue
- 4
- Pages
- 209-226
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W2093579930
- Cited by
- 240
- References
- 194
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 18 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 12 · 2016: 10 · 2015: 16 · 2014: 25 · 2013: 25 · 2012: 20
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Growth Factors (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- ribosome biogenesis, ribosome function, S6K, S6K1, mTOR signaling, 4E-BP1, cell growth regulation, protein synthesis, nutrient signaling, growth factor signaling, PI3K/Akt signaling, signaling crosstalk, cancer
- MeSH terms
- Protein Kinases, Ribosomes, RNA, Ribosomal, Protein Biosynthesis, Signal Transduction, Phosphatidylinositol 3-Kinases, Ribosomal Protein S6 Kinases, Cell Growth Processes, TOR Serine-Threonine Kinases
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