Fish protein intake induces fast-muscle hypertrophy and reduces liver lipids and serum glucose levels in rats
Abstract
In our previous study, fish protein was proven to reduce serum lipids and body fat accumulation by skeletal muscle hypertrophy and enhancing basal energy expenditure in rats. In the present study, we examined the precise effects of fish protein intake on different skeletal muscle fiber types and metabolic gene expression of the muscle. Fish protein increased fast-twitch muscle weight, reduced liver triglycerides and serum glucose levels, compared with the casein diet after 6 or 8 weeks of feeding. Furthermore, fish protein upregulated the gene expressions of a fast-twitch muscle-type marker and a glucose transporter in the muscle. These results suggest that fish protein induces fast-muscle hypertrophy, and the enhancement of basal energy expenditure by muscle hypertrophy and the increase in muscle glucose uptake reduced liver lipids and serum glucose levels. The present results also imply that fish protein intake causes a slow-to-fast shift in muscle fiber type.
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Ingestions of APP for 6 or 8 weeks induce significant increases in the gastrocnemius muscle weight and fiber diameters when comparing with ingestion of CAS in rats.
“The previous study demonstrated that ingestions of APP for 6 or 8 weeks induce significant increases in the gastrocnemius muscle weight and fiber diameters when comparing with ingestion of CAS (14–16) and a significant increase of myosin heavy-chain gene expression in Myh4 (14) in rats.”
From Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults (2020) · cites this paper as [14]
Alaska pollack protein (APP) ingestion induced more marked muscle hypertrophy compared with casein (CAS) in rat muscle.
“Mizushige and colleagues (14), Kawabata and colleagues (15), and Morisasa and colleagues (16) showed that Alaska pollack protein (APP) ingestion induced more marked muscle hypertrophy comparing with casein (CAS) in rat muscle (14–16).”
From Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults (2020) · cites this paper as [14]
Ingestions of APP for 6 or 8 weeks induce a significant increase of myosin heavy-chain gene expression in Myh4 in rats.
“The previous study demonstrated that ingestions of APP for 6 or 8 weeks induce significant increases in the gastrocnemius muscle weight and fiber diameters when comparing with ingestion of CAS (14–16) and a significant increase of myosin heavy-chain gene expression in Myh4 (14) in rats.”
From Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults (2020) · cites this paper as [14]
Mizushige and colleagues (15) and Kawabata and colleagues (14) suggested that muscle hypertrophy induced by APP ingestion leads the enhancement of basal energy expenditure.
“Moreover, Mizushige and colleagues (15) and Kawabata and colleagues (14) suggested that muscle hypertrophy induced by APP ingestion leads the enhancement of basal energy expenditure.”
From Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults (2020) · cites this paper as [14]
The intake of fish protein (APP) induced more marked muscle hypertrophy compared with casein in rat muscle.
“the intake of fish protein, i.e., APP, which Japan and other countries have traditionally consumed in daily meals, induced more marked muscle hypertrophy comparing with casein in rat muscle (Mizushige et al., 2010; Kawabata et al., 2015).”
From Effect of resistance training and fish protein intake on motor unit firing pattern and motor function of elderly (2018) · cites this paper as Kawabata et al., 2015
In a previous study, gastrocnemius muscle weight in rats was increased with APP intake, but not with casein intake, in 6 or 8 weeks with control of protein volumes comparing APP and casein groups.
“In a previous study, the gastrocnemius muscle weight in rats was increased with APP intake, but not with casein intake, in 6 or 8 weeks with the control of protein volumes on comparing APP and casein groups (Kawabata et al., 2015).”
From Effect of resistance training and fish protein intake on motor unit firing pattern and motor function of elderly (2018) · cites this paper as Kawabata et al., 2015
They also noted a significant increase of myosin heavy chain gene expression in Myh4, which is related to fast-twitch muscle fibers in the APP intake group.
“They also noted a significant increase of myosin heavy chain gene expression in Myh4, which is related to fast-twitch muscle fibers in the APP intake group.”
From Effect of resistance training and fish protein intake on motor unit firing pattern and motor function of elderly (2018) · cites this paper as Kawabata et al., 2015
Fish protein was able to increase skeletal muscle weight, especially fast-type muscle and fast-twitch fibers, in rats.
“In the same study, the authors found that fish protein was able to increase skeletal muscle weight, especially the fast-type muscle and fast-twitch fibers [56].”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [56]
Consumption of fish proteins resulted in less epididymal adipose tissue and lower plasma triglycerides in rats compared with consumption of casein.
“Kawabata et al. [56] reported that the consumption of fish proteins resulted in less epididymal adipose tissue and lower levels of plasma triglycerides in rats compared with the consumption of casein.”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [56]
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References 22 · Cited by 40
- Authors
- Kawabata, F., Mizushige, T., Uozumi, K., Hayamizu, K., Han, L., Tsuji, T., & Kishida, T.
- Affiliations
- Nippon Suisan Kaisha (Japan) (JP)
- Ehime University (JP)
- Human Life Science R&D Center, Nippon Suisan Kaisha, Ltd., Tokyo, Japan
- Corresponding author
- Kishida, Taro
- Venue
- Bioscience Biotechnology and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2015-01-02
- Volume
- 79
- Issue
- 1
- Pages
- 109-116
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2156995655
- Cited by
- 40
- References
- 22
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 8 · 2019: 4 · 2018: 1 · 2017: 3 · 2015: 3
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- fish protein, skeletal muscle fiber types, hepatic triglycerides, serum glucose, muscle glucose uptake, glucose transporter gene expression, basal energy expenditure, casein diet, metabolic gene expression
- MeSH terms
- Adipose Tissue, Animals, Blood Glucose, Body Weight, Carnitine O-Palmitoyltransferase, Caseins, Dietary Proteins, Energy Metabolism, Fishes, Gene Expression Regulation, Hypertrophy, Insulin Resistance, Liver, Male, Triglycerides, Rats, Sprague-Dawley, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Myosin Heavy Chains, Fish Proteins, Peroxisome Proliferator-Activated Receptors, Glucose Transporter Type 4, Rats
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