The DOI matches its Crossref record; 65 of the 69 references it cites were found in a registry or an index.
A preliminary investigation on the relationship between gut microbiota and gene expressions in peripheral mononuclear cells of infants with autism spectrum disorders
Open accessAbstract
Fecal and blood samples of infants with autism spectrum disorders (ASD) and healthy infants were analyzed to investigate the association of altered gut microbiota and ASD development. 16S rRNA gene-based sequencing found that, unlike those of healthy infants, feces of ASD infants had significantly higher and lower abundance of genera Faecalibacterium and Blautia, respectively. Moreover, DNA microarray analysis of peripheral blood mononuclear cells (PBMC) detected more highly than low expressed genes in ASD infants than in healthy infants. Gene Ontology analysis revealed that differentially expressed genes between ASD and healthy infants were involved in interferon (IFN)-γ and type-I IFN signaling pathways. Finally, strong positive correlations between expression of IFN signaling-associated genes in PBMC and fecal abundance of Faecalibacterium were found. Our results strongly suggested that altered gut microbiota in infants resulted from ASD development and was associated with systemic immunity dysregulation, especially chronic inflammation.
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Metadata
- Authors
- Inoue, R., Sakaue, Y., Sawai, C., Sawai, T., Ozeki, M., Romero-Pérez, G. A., & Tsukahara, T.
- Affiliations
- Laboratory of Animal Science, Department of Agricultural and Life Sciences, Kyoto Prefectural University, Kyoto, Japan
- Shiga University of Medical Science (JP)
- Mukogawa Women's University (JP)
- Kyoto Institute of Nutrition and Pathology, Kyoto, Japan
- Kyoto Prefectural University (JP)
- ORCID
- Tsukahara, Takamitsu
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2016-12-01
- Volume
- 80
- Issue
- 12
- Pages
- 2450-2458
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2516846297
- Cited by
- 148
- References
- 69
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 23 · 2023: 25 · 2022: 11 · 2021: 26 · 2020: 14 · 2019: 13 · 2018: 7 · 2017: 7 · 2016: 1
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The Morinaga Foundation for Health & Nutrition
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, gut microbiota, infants, peripheral blood mononuclear cells, gene expression, Faecalibacterium, Blautia, interferon-gamma signaling, type I interferon signaling, chronic inflammation, fecal microbiota
- MeSH terms
- Autism Spectrum Disorder, Gastrointestinal Microbiome, Child, Preschool, Feces, Humans, Infant, Leukocytes, Mononuclear, Case-Control Studies, Transcriptome
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